Quercetin Impact in Pancreatic Cancer: An Overview on Its Therapeutic Effects

Pancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing worldwide. Diagnosis of this cancer is complicated, as it does not often present symptoms, and most patients present an irremediable tumor having a 5-year survival rate after diagnosis. Regarding treatment, many concerns have also been raised, as most tumors are found at advanced stages. At present, anticancer compounds-rich foods have been utilized to control PC. Among such bioactive molecules, flavonoid compounds have shown excellent anticancer abilities, such as quercetin, which has been used as an adjunctive or alternative drug to PC treatment by inhibitory or stimulatory biological mechanisms including autophagy, apoptosis, cell growth reduction or inhibition, EMT, oxidative stress, and enhancing sensitivity to chemotherapy agents. The recognition that this natural product has beneficial effects on cancer treatment has boosted the researchers’ interest towards more extensive studies to use herbal medicine for anticancer purposes. In addition, due to the expensive cost and high rate of side effects of anticancer drugs, attempts have been made to use quercetin but also other flavonoids for preventing and treating PC. Based on related studies, it has been found that the quercetin compound has significant effect on cancerous cell lines as well as animal models. Therefore, it can be used as a supplementary drug to treat a variety of cancers, particularly pancreatic cancer. This review is aimed at discussing the therapeutic effects of quercetin by targeting the molecular signaling pathway and identifying antigrowth, cell proliferation, antioxidative stress, EMT, induction of apoptotic, and autophagic features.The authors acknowledge the Molecular Medicine Research Center, Bio-Medicine Institute, Tabriz University of Medical Sciences, and the Clinical Research Development Unit of Sina Educational, Research and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran. This work was supported and funded by Tabriz University of Medical Sciences, Tabriz, Iran (grant number: 68344)

Phenolic compounds as Nrf2 inhibitors : potential applications in cancer therapy

Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. EkynToSR555mbd1vVCBd11Video Abstrac

COVID-19 case dataset and its relationship with population density of Kazakhstan

This dataset describes the relationship between the population density of Kazakhstan and the current infection with COVID-19, as well as analyze the quarantine situation in Kazakhstan with the spread of the epidemic in the regions, in addition, our data might serve as a reference source for further predict the future spread of the coronavirus in the country

Floral composition of plant populations of Tаraxacum kok – saghyz

This database provides a floral composition of rare, endemic, valuable plants found in natural populations of the valuable plant Taraxacum kok - saghyz Rodin. 115 plant species belonging to 26 families grow in 3 studied populations ofTaraxacum kok - saghyz Rodin

COVID-19 case dataset and its relationship with population density of Kazakhstan

This dataset describes the relationship between the population density of Kazakhstan and the current infection with COVID-19, as well as analyze the quarantine situation in Kazakhstan with the spread of the epidemic in the regions, in addition, our data might serve as a reference source for further predict the future spread of the coronavirus in the country

Floristic Composition of plant populations of Tаraxacum kok – saghyz

This database provides a floral composition of rare, endemic, valuable plants found in natural populations of the valuable plant Taraxacum kok - saghyz Rodin. 115 plant species belonging to 26 families grow in 3 studied populations ofTaraxacum kok - saghyz Rodin

Anatomical structure of vegetative organs of the rare species Taraxacum kok‑saghyz L.E. Rodin in immature ontogenetic state

The article contains anatomical characteristics of vegetative organs of rare, endemic, and endangered species Taraxacum kok-saghyz, studied in three populations. The study found that the vegetative organs of plants are characterized by different degrees of development of certain tissues, depending on the place where they grow. The most favorable conditions for plant growth were in the place of population № 3, which was characterized by dark brown mountain soil type, with the layer of black soil (chernozem). It is known that the best soils for the cook-sagyz are strong, regular and leached chernozems – this had main influence on characteristics of growth of plants from population № 3. Since cooksaghyz is hygrophilous plants, the distinctive features of the internal structure of these plants also were affected by water conditions

Studies on the root anatomy of rubber producing endemic of Kazakhstan, Taraxacum Kok-Saghyz L.E. Rodin

This paper highlights morpho-metric and anatomical characteristics of a rare, endangered, endemic species Taraxacum kok-saghyz from Kazakhstan. The plant has been investigated using three different populations during young generative stages. The morphometric features recorded here from the natural populations show that, height of T. kok-saghyz plants and diameter of crown significantly increase in generative period. Plant roots contain milky tubes filled with coagulated latex-rubber threads, and are characterized by varying degrees of specific tissue development, depending on place of growth. Thus, it was found that plants of population ? 2 are characterized by significant development of primary cork (553.12 mkm=micron) and diameter of central cylinder (432.70 µ), in which narrow clearance xylem elements are concentrated. On the contrary, plants of population ? 3, have all signs of body xeromorphic structures (strong development of cover tissue and presence of more wide clearance vessels of water conducting tissue). Dark chestnut mountain soil type is the most favorable for plant growth and development. This taxon is a hygrophilous plant therefore water supply conditions affect distinctive features of plant internal structure. © 2018, Pakistan Agricultural Scientists Forum. All rights reserved.Ministry of Education and Science of the Republic of KazakhstanAcknowledgements: This research was conducted at the "Plant Ecology" research laboratory of the Faculty of Biology and Biotechnology at Al-Farabi Kazakh National University. Authors are thankful to them for their support. Our special thanks go to the ? Ministry of Education and Science ? , Republic of Kazakhstan for funding this study as a research project on basic research on the "biological characteristics, current status and protection of cenopopulations of some rare plant species in Almaty region". -