Trace element studies on Karachi populations Part V: Blood lead levels in normal healthy adults and grammar school children

Blood lead levels of healthy Karachi population were estimated. Mean levels for males, females, soldiers and school children were 34.4, 31.8, 29.9 and 38.2 micrograms/dl respectively. About 93% cases of either sex had elevated lead levels, of whom 30% males and 10% females had levels above the safety limits (40 micrograms/dl). Soldiers living in relatively pollution free area though had levels lower than the rest of the population but 91% had levels over 25 micrograms/dl and only two had acceptable levels. Ninety-two percent children showed levels above 25 micrograms/dl with a large number having levels over 40 micrograms/dl. A very small percentage had normal levels. Pollution by traffic exhaust was assumed to be the principal cause for these high levels

Composite vertices that lead to soft form factors

The momentum-space cut-off parameter $\Lambda$ of hadronic vertex functions is studied in this paper. We use a composite model where we can measure the contributions of intermediate particle propagations to $\Lambda$. We show that in many cases a composite vertex function has a much smaller cut-off than its constituent vertices, particularly when light constituents such as pions are present in the intermediate state. This suggests that composite meson-baryon-baryon vertex functions are rather soft, i.e., they have \Lambda considerably less than 1 GeV. We discuss the origin of this softening of form factors as well as the implications of our findings on the modeling of nuclear reactions.Comment: REVTex, 19 pages, 5 figs(to be provided on request

Gold nanoparticle decorated single walled carbon nanotube nanocomposite with synergistic peroxidase like activity for D-alanine detection

© The Royal Society of Chemistry. In this report, a gold nanoparticle decorated single walled carbon nanotube (SWCNTs) nanocomposite was shown to possess synergistic intrinsic peroxidase like activity and enhanced affinity towards H2O2 oxidation. The gold nanoparticle decorated SWCNTs nanocomposite was characterized by high catalytic activity, enhanced stability from the gold nanoparticles and improved dispersion from the SWCNTs. Subsequently, this nanocomposite was proved to be a novel peroxidase mimetic with great potential to catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H2O2 to yield a blue colored product. As a proof of concept, the gold nanoparticle decorated SWCNTs composite was used as a robust nanoprobe for the detection of d-alanine with improved analytical characteristics. Taking into account the valuable intrinsic peroxidase activity of the nanohybrid, the present work may find widespread applications in the field of sensors and biosensors for diverse applications. This journal i

Sialic acid transport and catabolism are cooperatively regulated by SiaR and CRP in nontypeable Haemophilus influenzae

BACKGROUND: The transport and catabolism of sialic acid, a critical virulence factor for nontypeable Haemophilus influenzae, is regulated by two transcription factors, SiaR and CRP. RESULTS: Using a mutagenesis approach, glucosamine-6-phosphate (GlcN-6P) was identified as a co-activator for SiaR. Evidence for the cooperative regulation of both the sialic acid catabolic and transport operons suggested that cooperativity between SiaR and CRP is required for regulation. cAMP was unable to influence the expression of the catabolic operon in the absence of SiaR but was able to induce catabolic operon expression when both SiaR and GlcN-6P were present. Alteration of helical phasing supported this observation by uncoupling SiaR and CRP regulation. The insertion of one half-turn of DNA between the SiaR and CRP operators resulted in the loss of SiaR-mediated repression of the transport operon while eliminating cAMP-dependent induction of the catabolic operon when GlcN-6P was present. SiaR and CRP were found to bind to their respective operators simultaneously and GlcN-6P altered the interaction of SiaR with its operator. CONCLUSIONS: These results suggest multiple novel features for the regulation of these two adjacent operons. SiaR functions as both a repressor and an activator and SiaR and CRP interact to regulate both operons from a single set of operators

Toward a unified description of hadro- and photoproduction: S-wave pi- and eta-photoproduction amplitudes

The Chew-Mandelstam parameterization, which has been used extensively in the two-body hadronic sector, is generalized in this exploratory study to the electromagnetic sector by simultaneous fits to the pion- and eta-photoproduction S-wave multipole amplitudes for center-of-mass energies from the pion threshold through 1.61 GeV. We review the Chew-Mandelstam parameterization in detail to clarify the theoretical content of the SAID hadronic amplitude analysis and to place the proposed, generalized SAID electromagnetic amplitudes in the context of earlier employed parameterized forms. The parameterization is unitary at the two-body level, employing four hadronic channels and the gamma-N electromagnetic channel. We compare the resulting fit to the MAID parameterization and find qualitative agreement though, numerically, the solution is somewhat different. Applications of the extended parameterization to global fits of the photoproduction data and to global fits of the combined hadronic and photoproduction data are discussed.Comment: 9 pages, 9 figures; added figures and tex

Extension Professionals\u27 Perspectives on Supporting Feedstock Production for Biofuels: Concerns, Challenges, and Opportunities

The development of successful bioenergy programs will depend on informed and prepared Extension professionals who are willing and equipped to provide technical support. A survey of Extension professionals in the Pacific Northwest revealed barriers to program development, including limits on time and knowledge and concerns about economic returns for biofuel crops. Without the promise of market opportunities, Extension professionals may be unwilling to devote requisite resources to bioenergy programs. However, government policies and mandates make the rise of biofuels highly likely. Extension professionals should look to the future and consider blending bioenergy education into existing programs

Growing Green Energy: A Review of Extension\u27s Role in the Development of Advanced Biofuels

The development of advanced biofuels is expanding the possibilities for purpose-grown energy crops. Growers, producers, and other stakeholders will need a reliable source of information to assist with decision-making regarding renewable fuel supply chains. This review examines Extension\u27s role in the innovation of advanced biofuels by documenting and summarizing Extension work in existing biomass-derived energy programs. This review highlights strategies used by Extension programs that help make renewable energy innovations successful

Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis

Objectives: To summarise evidence on the associations of maternal anaemia and prenatal iron use with maternal haematological and adverse pregnancy outcomes; and to evaluate potential exposure-response relations of dose of iron, duration of use, and haemoglobin concentration in prenatal period with pregnancy outcomes. Design: Systematic review and meta-analysis Data sources Searches of PubMed and Embase for studies published up to May 2012 and references of review articles. Study selection criteria Randomised trials of prenatal iron use and prospective cohort studies of prenatal anaemia; cross sectional and case-control studies were excluded. Results: 48 randomised trials (17 793 women) and 44 cohort studies (1 851 682 women) were included. Iron use increased maternal mean haemoglobin concentration by 4.59 (95% confidence interval 3.72 to 5.46) g/L compared with controls and significantly reduced the risk of anaemia (relative risk 0.50, 0.42 to 0.59), iron deficiency (0.59, 0.46 to 0.79), iron deficiency anaemia (0.40, 0.26 to 0.60), and low birth weight (0.81, 0.71 to 0.93). The effect of iron on preterm birth was not significant (relative risk 0.84, 0.68 to 1.03). Analysis of cohort studies showed a significantly higher risk of low birth weight (adjusted odds ratio 1.29, 1.09 to 1.53) and preterm birth (1.21, 1.13 to 1.30) with anaemia in the first or second trimester. Exposure-response analysis indicated that for every 10 mg increase in iron dose/day, up to 66 mg/day, the relative risk of maternal anaemia was 0.88 (0.84 to 0.92) (P for linear trend<0.001). Birth weight increased by 15.1 (6.0 to 24.2) g (P for linear trend=0.005) and risk of low birth weight decreased by 3% (relative risk 0.97, 0.95 to 0.98) for every 10 mg increase in dose/day (P for linear trend<0.001). Duration of use was not significantly associated with the outcomes after adjustment for dose. Furthermore, for each 1 g/L increase in mean haemoglobin, birth weight increased by 14.0 (6.8 to 21.8) g (P for linear trend=0.002); however, mean haemoglobin was not associated with the risk of low birth weight and preterm birth. No evidence of a significant effect on duration of gestation, small for gestational age births, and birth length was noted. Conclusions: Daily prenatal use of iron substantially improved birth weight in a linear dose-response fashion, probably leading to a reduction in risk of low birth weight. An improvement in prenatal mean haemoglobin concentration linearly increased birth weight