ЛИМФОКИНЕТИЧЕСКАЯ АКТИВНОСТЬ КОМПОЗИЦИИ ДИГИДРОКВЕР-ЦЕТИНА И АРАБИНОГАЛАКТАНА

Purpose. To evaluate lymphokinetic activity of the dihydroquercetin and arabinogalactan composition.Material and methods. The investigation was carried out on male Wistar rats. Lymphokinetic activity was determined by the rate of lymph outflow through the puncture of cisterna chili after intragastricall administration of the dihydroquercetin and arabinogalactan composition with ratio 1 : 5 (50 mg/kg + 250 mg/kg).Results. It was established that lymphokinetic activity of the dihydroquercetin and arabinogalactan composition with ratio 1 : 5 (50 mg/kg + 250 mg/kg) exceeds activity of it´s components.Проведено исследование лимфокинетической активности композиции дигидрокверцетина и арабиногалактана.Эксперименты выполнены на крысах-самцах линии Wistar. Лимфокинетическую активность определяли по скорости оттока лимфы через прокол млечной цистерны после внутрижелудочного введения композиции дигидрокверцетина и арабиногалактана в соотношении 1 : 5 (50 мг/кг + 250 мг/кг).Установлено, что лимфокинетическая активность композиции дигидрокверцетина и арабинога­лактана в соотношении 1 : 5 превосходит активность ее отдельных компонентов

Dynamics of blood pressure elevation and endothelial dysfunction in SHR rats during the development of arterial hypertension

The dynamics of systolic and diastolic BP and vasodilatory activity of the endothelium in SHR and Wistar-Kyoto rats was studied from the 5th to the 12th week of life. Systolic and diastolic BP did not differ in 5-week-old SHR and Wistar-Kyoto rats. After the 6th week of life, two stages of arterial hypertension development were observed in SHR. Stage 1 (weeks 6-8) was characterized by a significant increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 26-32%. Vasodilatory activity of the endothelium was similar in rats of both strains at the age of 5-7 weeks. Stage 2 (weeks 9-12) in SHR rats was characterized by further increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 54-89%. The increase in BP during this period was accompanied by a significant decrease in endothelium-dependent relaxation (by 14-16% compared to that in Wistar-Kyoto rats of the same age)

HYPERVISCOSITY SYNDROME IN ARTERIAL HYPERTENSION AND HEMORHEOLOGICAL EFFECTS OF ANTIHYPERTENSIVE DRUGS

Current study briefly shows the pathological changes of blood rheological properties in arterial hypertension and the impact of main rheological parameters is discussed (hematocrit, plasma viscosity, aggregation, erythrocyte deformity) on the development of blood hyperviscosity syndrome. The data is provided on the influence of antihypertension drugs (angiotensin converting enzyme inhibitors, calcium channel antagonists, andrenoblockers, diuretics and angiotensin II receptor blockers) on blood rheology in patients with arterial hypertension

Dynamics of blood pressure elevation and endothelial dysfunction in SHR rats during the development of arterial hypertension

The dynamics of systolic and diastolic BP and vasodilatory activity of the endothelium in SHR and Wistar-Kyoto rats was studied from the 5th to the 12th week of life. Systolic and diastolic BP did not differ in 5-week-old SHR and Wistar-Kyoto rats. After the 6th week of life, two stages of arterial hypertension development were observed in SHR. Stage 1 (weeks 6-8) was characterized by a significant increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 26-32%. Vasodilatory activity of the endothelium was similar in rats of both strains at the age of 5-7 weeks. Stage 2 (weeks 9-12) in SHR rats was characterized by further increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 54-89%. The increase in BP during this period was accompanied by a significant decrease in endothelium-dependent relaxation (by 14-16% compared to that in Wistar-Kyoto rats of the same age)

Pharmacological activity of composition on the base of dihydroquercertin and lipoic acid

The purpose of this investigation is to the estimate influence of composition dihydroquercertin and lipoic acid on lymphatic flow, capillary filtration and blood viscosity in comparison with effects of individual components. Lymphokinetic activity of dihydroquercertin was detected. Capillary-protective effect, but in less degree lymphokinetic and hemorheologic ones of composition are higher than the effect of its separate components