Aurora A kinase activity influences calcium signaling in kidney cells

Aurora A is abnormally expressed and activated in cells lining cysts associated with polycystic kidney disease and can phosphorylate and inactivate polycystin 2

Control system of parameters of the azimuthal module

Analytical and experimental studies of the azimuthal module of two-component vibrational micromechanical gyroscope were conducted. It is shown that the micromechanical gyroscope is a system with distributed parameters. The frequency analysis is performed using software T-Flex. The influence of mechanical disturbances on the movement of azimuthal module in the form of translational and angular oscillations is shown; the natural frequencies of the azimuth are defined

The acidity of the hydroxy-tautomeric form of dimethylphosphite stabilized with chromium group metals

© 2016 Taylor & Francis Group, LLC.We have revealed that the reaction of hexacarbonylmetal(0) with the dimethylphosphite can afford the organometallic species having the hydroxyl-tautomeric form of the H-phosphonate in the metals’ coordination sphere. Theoretical and experimental investigations reveal the strong acidity of these organometallic compounds aswell as their possibility to take part in electrophilic hydrophosphorylation of inactivated C=C and C≡C bonds

ORGANIZATIONAL AND ECONOMIC ASPECTS OF IMPROVING SUBURBAN RAILWAY TRANSPORTATION

The features of management of domestic railway transport at different stages of its development have been disclosed. The main principles and conditions of structural reform in the industry have been formulated. The main models of management of the railway complex, principles and features of the organization of suburban railway communication in different countries have been characterized. Statistical data on suburban rail transport on the infrastructure of JSC «Russian Railways», confirming their importance and significance for the Russian Federation, have been adduced. The economic results of the activity of domestic suburban passenger companies have been considered. The shortcomings of the existing methodology for assessing the financial condition of suburban passenger companies have been indicated. The proposals to improve the current methods of calculations taking into account the conditions of prospective development of companies have been given. The scheme of scientific and methodical approach to the analysis of economic condition of the suburban passenger companies, including set of procedures of calculated and analytical character, has been offered

Formation of high-carbon abrasion-resistant surface layers when high-energy heating by high-frequency currents

The paper shows the possibility of carburization of low-carbon steel surface layers using high-frequency currents. The mathematical modeling of carburization using high-energy heating by high-frequency currents (HEH HFC) has been carried out, the temperature fields formed during the given processing have been calculated, as well as the structural changes in the surface layers have been simulated. The features of the structure formation in the surface layers of low-carbon steel after carburizing via HEH HFC have been determined by optical and scanning microscopy, which is confirmed by the computational models. The rational mode of fusion via HEH HFC has also been determined (power density of the source q[s]=(1.5...4.0)•10{8} W m{-2}, (the relative travel speed of parts V[p]=5 ... 100 mm /sec), with forming the compressive retained stresses in the surface layer ([sigma][RS]=-300...-400 MPa)

Space and time in the context of social measurement

This paper discusses some of the basic philosophical concepts – the concepts of “space and time” - and their relation to social evolution. The work presents the characteristics of social forms of space and time, shows the specifics of their formation in connection with human activity and the system of social relations. It was found that time duration has different manifestations in the context of historically different cultural epochs. Acceleration of social time takes place in the course of human historical practice development. Meanwhile, some social systems sometimes take the form of a certain deceleration in time. This usually occurs because of the inadequacy of the control system for the capabilities of the social organism. Social space is primarily connected with the dynamics of changes in social bonds and relationships. In the process of historical formation of social systems, social space assumes a more complex structure and expands. In the period of globalization growth, social space takes the form of a truly global integral system.peer-reviewe

Choice of parameters and stability of nonlinear vibration isolation device

Work of active vibration isolation devices with single-mass electromagnetic suspension taking into account of real characteristics of the voltage regulators is described. The analytical researches are carried out; the areas of stability of work of nonlinear vibration isolation device are defined

CITIZENSHIP IN THE STRUCTURE OF SOCIO-POLITICAL ORIENTATIONS OF RUSSIAN YOUTH: PLACE AND ROLE IN STATEHOOD STRENGTHENING

Purpose of the study: In this study, we analyze citizenship in the structure of socio-political orientations of Russian youth and explore the youth role in strengthening statehood and formation of civil society institutions. The development of active citizenship values in sociopolitical orientations of Russian youth is determined by the need to change relations between the state and society. The citizens shall develop civic responsibility and civil initiatives and control the institutions of power. Methodology: The theory of social anomie and the concept of socio-cultural crisis serve the methodological basis for this study. This theory explores the eclectic nature of citizenship ideas in the youth environment. The civilizational approach makes it possible to investigate features of citizenship idea and practice information of Western European and Russian cultural traditions. All that is methodologically significant in tracking citizenship specificity of the Russian youth. The integrated approach becomes a conceptual one in this study as it treats the citizenship of Russian youth as a complex multi-component phenomenon. This phenomenon includes moral, legal and socio-political attitudes reflecting the various aspects of relations in the "man-society-state" system. Results: We conclude that in the citizenship of Russian youth there dominate two main attitudes: liberal and paternalistic. In the liberal aspect, the young people consider citizenship to be awareness of their civil rights and responsibilities, a kind of rational and active behavior corresponding to democratic political system. Paternalistic attitudes are manifested in loyalty to the state. Paternalists consider the state to be the political institution that is solely responsible for the present and future of the young people. Applications of this study: The results allow us to understand the significance of citizenship as an ethic-legal quality of personality that strengthens Russian statehood and the importance of agreement (contract) between government and society. The results discovered the need for the citizens to be engaged in solving the state's socially significant problems. The state shall also develop a favorable institutional environment for civil socialization and self-realization of the young people. Novelty/Originality of this study: The eclectic nature of Russian youth citizenship points at hindering factors in the development of active and responsible citizenship as the youth ability to self-organize and solve socially significant problems. The main factors hindering the process of civil activity formation among the young people are the stable etatist-paternalistic traditions of political culture and institutions of Russian civil society. Although, development of youth citizenship is a well-managed process. It requires the youth policy to be the stimulating and guiding force. This force is necessary to solve the problems of legal personality type formation. Such a personality is characterized by politically and socially active civic-mindedness

Rapid calcium-dependent activation of Aurora-A kinase

Oncogenic hyperactivation of the mitotic kinase Aurora-A (AurA) in cancer is associated with genomic instability. Increasing evidence indicates that AurA also regulates critical processes in normal interphase cells, but the source of such activity has been obscure. We report here that multiple stimuli causing release of Ca2+ from intracellular endoplasmic reticulum stores rapidly and transiently activate AurA, without requirement for second messengers. This activation is mediated by direct Ca2+-dependent calmodulin (CaM) binding to multiple motifs on AurA. On the basis of structure–function analysis and molecular modelling, we map two primary regions of CaM-AurA interaction to unfolded sequences in the AurA N- and C-termini. This unexpected mechanism for AurA activation provides a new context for evaluating the function of AurA and its inhibitors in normal and cancerous cells