The transcriptome of type i murine astrocytes under interferon-gamma exposure and remyelination stimulus

© 2017 by the authors.Astrocytes are considered to be an important contributor to central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released by lymphocytes, penetrating the blood-brain barrier - in particular, the classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that the expression of genes involved in antigen processing and presentation in astrocytes are significantly upregulated upon IFNγ exposure, emphasizing the critical role of this cytokine in the redirection of immune response towards self-antigens. Data reported herein support previous observations that the IFNγ-induced JAK-STAT signaling pathway may be regarded as a valuable target for pharmaceutical interventions

NP-Hardness of the Problem of Optimal Box Positioning

We consider the problem of finding a position of a d-dimensional box with given edge lengths that maximizes the number of enclosed points of the given finite set P ⊂ R d , i.e., the problem of optimal box positioning. We prove that while this problem is polynomial for fixed values of d, it is NP-hard in the general case. The proof is based on a polynomial reduction technique applied to the considered problem and the 3-CNF satisfiability problem

FILM MATERIALS WITH TIAMULIN FUMARATE ON THE BASIS OF POLYURETHANEUREAS, WHICH CONTAINING IN THE STRUCTURE FRAGMENTS OF A COPOLYMER OF N-VINYLPYRROLIDONE WITH VINYL ALCOHOL

A series of hydrophilic film materials with tiamulin fumarate based on polyurethaneureas  (PUU) which contain in its structure fragments of the copolymer N-vinylpyrrolidone and  vinyl alcohol at various ratios of components. The structure of the obtained polymer materials  was investigated by the method of IR-spectroscopy. It was established that immobilization of tiamulin fumarate occurs due to physical bonds. The introduction of the tiamulin fumarate in to PUU leads to increased physical and mechanical properties which are within the 3,0-7,3 MPa. Polymeric materials with tiamulin fumarate synthesized at ratio GMDA to VP-VA as 70 to 30 characterized by most high values of strength (7.3 MPa) and the relative elongation at break (100%) and can be offered for medical and biological tests

The transcriptome of type i murine astrocytes under interferon-gamma exposure and remyelination stimulus

© 2017 by the authors.Astrocytes are considered to be an important contributor to central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released by lymphocytes, penetrating the blood-brain barrier - in particular, the classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that the expression of genes involved in antigen processing and presentation in astrocytes are significantly upregulated upon IFNγ exposure, emphasizing the critical role of this cytokine in the redirection of immune response towards self-antigens. Data reported herein support previous observations that the IFNγ-induced JAK-STAT signaling pathway may be regarded as a valuable target for pharmaceutical interventions