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The transcriptome of type i murine astrocytes under interferon-gamma exposure and remyelination stimulus
Authors
Belogurov A.
Gabibov A.
+6 more
Galatenko V.
Khaustova N.
Kudriaeva A.
Kuzina E.
Maltseva D.
Tonevitsky A.
Publication date
1 January 2017
Publisher
Abstract
© 2017 by the authors.Astrocytes are considered to be an important contributor to central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released by lymphocytes, penetrating the blood-brain barrier - in particular, the classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that the expression of genes involved in antigen processing and presentation in astrocytes are significantly upregulated upon IFNγ exposure, emphasizing the critical role of this cytokine in the redirection of immune response towards self-antigens. Data reported herein support previous observations that the IFNγ-induced JAK-STAT signaling pathway may be regarded as a valuable target for pharmaceutical interventions
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Kazan Federal University Digital Repository
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oai:dspace.kpfu.ru:net/145298
Last time updated on 07/05/2019
Kazan Federal University Digital Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.kpfu.ru:net/113773
Last time updated on 07/05/2019