Different expressions of the same mode: a recent dialogue between archaeological and contemporary drawing practices

In this article we explore what we perceive as pertinent features of shared experience at the excavations of an Iron Age Hillfort at Bodfari, North Wales, referencing artist, archaeologist and examples of seminal art works and archaeological records resulting through inter-disciplinary collaboration. We explore ways along which archaeological and artistic practices of improvisation become entangled and productive through their different modes of mark-making. We contend that marks and memories of artist and archaeologist alike emerge interactively, through the mutually constituting effects of the object of study, the tools of exploration, and the practitioners themselves, when they are enmeshed in the cross-modally bound activities. These include, but are not limited to, remote sensing, surveying, mattocking, trowelling, drawing, photographing, videoing and sound recording. These marks represent the co-signatories: the gesture of the often anonymous practitioners, the voice of the deposits, as well as the imprint of the tools, and their interplay creates a multi-threaded narrative documenting their modes of intra-action, in short our practices. They occupy the conceptual space of paradata, and in the process of saturating the interstices of digital cognitive prosthetics they lend probity to their translations in both art form and archive

Marginal increase of sunitinib exposure by grapefruit juice

Clinical Oncolog

КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ. ДИАГНОСТИКА И ЛЕЧЕНИЕ РАКА РОТОГЛОТКИ

Клинические рекомендации подготовлены на основании материалов научно-практической конференции Проблемной комиссии «Опухоли головы и шеи» Научного совета по злокачественным новообразованиям Отделения медицинских наук Российской академии наук и Министерства здравоохранения РФ, посвященной памяти профессора Александра Ильича Пачеса, «Актуальные вопросы диагностики и лечения рака ротоглотки» (25 июня 2015 г., г. Архангельск).Клинические рекомендации подготовлены на основании материалов научно-практической конференции Проблемной комиссии «Опухоли головы и шеи» Научного совета по злокачественным новообразованиям Отделения медицинских наук Российской академии наук и Министерства здравоохранения РФ, посвященной памяти профессора Александра Ильича Пачеса, «Актуальные вопросы диагностики и лечения рака ротоглотки» (25 июня 2015 г., г. Архангельск)

Common Genetic Denominators for Ca++-Based Skeleton in Metazoa: Role of Osteoclast-Stimulating Factor and of Carbonic Anhydrase in a Calcareous Sponge

Calcium-based matrices serve predominantly as inorganic, hard skeletal systems in Metazoa from calcareous sponges [phylum Porifera; class Calcarea] to proto- and deuterostomian multicellular animals. The calcareous sponges form their skeletal elements, the spicules, from amorphous calcium carbonate (ACC). Treatment of spicules from Sycon raphanus with sodium hypochlorite (NaOCl) results in the disintegration of the ACC in those skeletal elements. Until now a distinct protein/enzyme involved in ACC metabolism could not been identified in those animals. We applied the technique of phage display combinatorial libraries to identify oligopeptides that bind to NaOCl-treated spicules: those oligopeptides allowed us to detect proteins that bind to those spicules. Two molecules have been identified, the (putative) enzyme carbonic anhydrase and the (putative) osteoclast-stimulating factor (OSTF), that are involved in the catabolism of ACC. The complete cDNAs were isolated and the recombinant proteins were prepared to raise antibodies. In turn, immunofluorescence staining of tissue slices and qPCR analyses have been performed. The data show that sponges, cultivated under standard condition (10 mM CaCl2) show low levels of transcripts/proteins for carbonic anhydrase or OSTF, compared to those animals that had been cultivated under Ca2+-depletion condition (1 mM CaCl2). Our data identify with the carbonic anhydrase and the OSTF the first two molecules which remain conserved in cells, potentially involved in Ca-based skeletal dissolution, from sponges (sclerocytes) to human (osteoclast)

Mammographic density and breast cancer risk: current understanding and future prospects

Variations in percent mammographic density (PMD) reflect variations in the amounts of collagen and number of epithelial and non-epithelial cells in the breast. Extensive PMD is associated with a markedly increased risk of invasive breast cancer. The PMD phenotype is important in the context of breast cancer prevention because extensive PMD is common in the population, is strongly associated with risk of the disease, and, unlike most breast cancer risk factors, can be changed. Work now in progress makes it likely that measurement of PMD will be improved in the near future and that understanding of the genetics and biological basis of the association of PMD with breast cancer risk will also improve. Future prospects for the application of PMD include mammographic screening, risk prediction in individuals, breast cancer prevention research, and clinical decision making

THE ROLE OF CHRONIC POLYPOID RHINOSINUSITIS IN OCCURRENCE OF MALIGNANT EPITHELIAL TUMORS OF THE PARANASAL SINUSES AND THE NASAL CAVITY

Growth of occurrence of malignant epithelial tumors of the nasal cavity (NC) and the paranasal sinuses (PNS) is noted. Absolute majority of patients come for treatment with the III and the IV stage of the disease. No trend for decreasing of the untreatedness parameter is observed. Increasing of the efficiency of treatment of patients with cancer depends on timely diagnostics. The main reason of late diagnostics is insufficient oncological alertness of doctors in polyclinics. The issues of therapy tactics at the stage of pre-tumor diseases of the NC and the PNS remain unsolved, while background process that precede development of cancer are morphologically revealed with 56.7 % of patients. One of the most frequently occurred background development processes of the NC and the PNS cancer is chronic polypoid rhinosinusitis (CPR). The degree of occurrence of CPR is high, and the annual growth of its incidence by 2 to 4 % has been observed for the previous 10 years. There are only certain works that view CPR as a pre-cancer disease.The objective of the study is improvement of results of early diagnostics of cancer and optimization of the surgical tactics with pre-cancer diseases of the upper jaw and the PNS.Materials and methods. Retrospective and prospective clinical and morphological analysis of data of 58 patients with benign polypous changes (BPC) and of 182 patients with malignant epithelial tumors (MET)  of the NC and the PNS treated at the Arkhangelsk Regional Clinical Oncology Dispensary from 1980 to 2010 has been performed.Results and discussion The maximum number of patients in both groups is at the age category from 40 to 59 years. Besides, the average age of patients with the BPC was lower than that of the patients with the MET (45.6 ± 2.3 and 54.0 ± 1.5 years old, respectively).Patients of working age prevailed both in the group with the BPC and the group with the MET of the NC and the PNS (19.0 / 81.0 % and 39.6 / 62.1 %, respectively). Males prevailed in the group with the BPC (53.4 % of males and 46.6 % of females), and females prevailed in the group with the MET (39.6 % of males and 60.4 % of females). However, we believe that this controversy to our hypothesis is explained with greater life expectancy of females (females are the prevailing majority in the groups of age category of 70 to 89 years old: 19.8 % are females, 5.3 % are males).The prevailing number of patients with the BPC (77.6 %) lived in cities, and such number in the group of patients with the MET was 54.9 %. The most frequent type of operative treatment of patients with the BPC was electrical maxillar ethmoidectomy that was performed in 82.9 % of cases. Relapse after performance of electrical maxillar ethmoidectomy was demostrated by 2 patients which comprised 4.3 %.In significant number of cases (70,6 % in the group with the BPC and 65.9 % in the group with the MET), the pathological process was localized in the maxillar cavity. Most frequently, glandular-fibrous polyps were revealed (42.1 %), and this morphological structure prevaled with male patients (57.9 % with males and 26.3 % with females); MET of the NC and the PNS, in their turn, also more frequently occurred with males.In 69.0 %, the CPR has been the background for severe epithelial dysplasia, and the CPR, in its turn, was reveled with 39.8 % of patients with the MET.Conclusion. We believe that the data provided prove the key role of the CPR in development of MET of the NC and the PNS

TREATMENT POLICY FOR STAGES CT1–2CN0M0 ORAL SQUAMOUS CELL CARCINOMA

The paper deals with the choice of treatment for oral squamous cell carcinoma: which of treatment options (surgery, radiation, or their combination) will be most suitable for squamous cell carcinoma of the mouth and tongue; how to affect regional metastatic regions in cN0

DIAGNOSIS AND TREATMENT OF OROPHARYNGEAL CANCER. CLINICAL RECOMMENDATIONS

Клинические рекомендации подготовлены на основании материалов научно-практической конференции Проблемной комиссии «Опухоли головы и шеи» Научного совета по злокачественным новообразованиям Отделения медицинских наук Российской академии наук и Министерства здравоохранения РФ, посвященной памяти профессора Александра Ильича Пачеса, «Актуальные вопросы диагностики и лечения рака ротоглотки» (25 июня 2015 г., г. Архангельск)