Continuity in the neural system supporting children's theory of mind development: Longitudinal links between task-independent EEG and task-dependent fMRI.

Children's explicit theory of mind (ToM) understandings change over early childhood. We examined whether there is longitudinal stability in the neurobiological bases of ToM across this time period. A previous study found that source-localized resting EEG alpha attributable to the dorsal medial prefrontal cortex (DMPFC) and right temporoparietal junction (RTPJ) was associated with children's performance on a battery of theory of mind tasks. Here, we investigated a small subset of children (N = 12) in that original study as a preliminary investigation of whether behavioral measures of ToM performance, and/or EEG localized to the DMPFC or RTPJ predicted ToM-specific fMRI responses 3.5 years later. Results showed that preschoolers' behavioral ToM-performance positively predicted later ToM-specific fMRI responses in the DMPFC. Preschoolers' resting EEG attributable to the DMPFC also predicted later ToM-specific fMRI responses in the DMPFC. Given the small sample, results represent a first exploration and require replication. Intriguingly, they suggest that early maturation of the area of the DMPFC related to ToM reasoning is positively linked with its specific recruitment for ToM reasoning later in development, affording implications for characterizing conceptual ToM development, and its underlying neural supports

A Type System for Tom

Extending a given language with new dedicated features is a general and quite used approach to make the programming language more adapted to problems. Being closer to the application, this leads to less programming flaws and easier maintenance. But of course one would still like to perform program analysis on these kinds of extended languages, in particular type checking and inference. In this case one has to make the typing of the extended features compatible with the ones in the starting language. The Tom programming language is a typical example of such a situation as it consists of an extension of Java that adds pattern matching, more particularly associative pattern matching, and reduction strategies. This paper presents a type system with subtyping for Tom, that is compatible with Java's type system, and that performs both type checking and type inference. We propose an algorithm that checks if all patterns of a Tom program are well-typed. In addition, we propose an algorithm based on equality and subtyping constraints that infers types of variables occurring in a pattern. Both algorithms are exemplified and the proposed type system is showed to be sound and complete

Th.o.m.a.s.: An exploratory assessment of Theory of Mind in schizophrenic subjects

A large body of literature agrees that persons with schizophrenia suffer from a Theory of Mind (ToM) deficit. However, most empirical studies have focused on third-person, egocentric ToM, underestimating other facets of this complex cognitive skill. Aim of this research is to examine the ToM of schizophrenic persons considering its various aspects (first vs. second order, first vs. third person, egocentric vs. allocentric, beliefs vs. desires vs. positive emotions vs. negative emotions and how each of these mental state types may be dealt with), to determine whether some components are more impaired than others. We developed a Theory of Mind Assessment Scale (Th.o.m.a.s.) and administered it to 22 persons with a DSM-IV diagnosis of schizophrenia and a matching control group. Th.o.m.a.s. is a semi-structured interview which allows a multi-component measurement of ToM. Both groups were also administered a few existing ToM tasks and the schizophrenic subjects were administered the Positive and Negative Symptoms Scale and the WAIS-R. The schizophrenic persons performed worse than control at all the ToM measurements; however, these deficits appeared to be differently distributed among different components of ToM. Our conclusion is that ToM deficits are not unitary in schizophrenia, which also testifies to the importance of a complete and articulated investigation of ToM

Integrated transfers of terrigenous organic matter to lakes at their watershed level: A combined biomarker and GIS analysis

Terrigenous organic matter (TOM) transfer from a watershed to a lake plays a key role in contaminants fate and greenhouse gazes emission in these aquatic ecosystems. In this study, we linked physiographic and vegetation characteristics of a watershed with TOM nature deposited in lake sediments. TOM was characterized using lignin biomarkers as indicators of TOM sources and state of degradation. Geographical information system (GIS) also allowed us to integrate and describe the landscape morpho-edaphic characteristics of a defined drainage basin. Combining these tools we found a significant and positive relationship (R2 = 0.65, p < 0.002) between mean slope of the watershed and the terrigenous fraction estimated by Λ8 in recent sediments. The mean slope also correlated with the composition of TOM in recent sediments as P/(V + S) and 3,5Bd/V ratios significantly decreased with the steepness of the watersheds (R2 = 0.57, p < 0.021 and R2 = 0.71, p < 0.004, respectively). More precisely, areas with slopes comprised between 4° and 10° have a major influence on TOM inputs to lakes. The vegetation composition of each watershed influenced the composition of recent sediments of the sampled lakes. The increasing presence of angiosperm trees in the watershed influenced the export of TOM to the lake as Λ8 increased significantly with the presence of this type of vegetation (R2 = 0.44, p < 0.019). A similar relationship was also observed with S/V ratios, an indicator of angiosperm sources for TOM. The type of vegetation also greatly influenced the degradation state of OM. In this study, we were able to determine that low-sloped areas (0–2°) act as buffer zones for lignin inputs and by extension for TOM loading to sediments. The relative contribution of TOM from the soil organic horizons also increased in steeper watersheds. This study has significant implications in our understanding of the fate of TOM in lacustrine ecosystems

In two minds: executive functioning versus theory of mind in behavioural variant frontotemporal dementia

Background: The relationship of executive function (EF) and theory of mind (ToM) deficits in neurodegeneration is still debated. There is contradicting evidence as to whether these cognitive processes are overlapping or distinct, which has clear clinical relevance for the evaluation of their associated clinical symptoms. Aim: To investigate the relationship of EF and ToM deficits via a data-driven approach in a large sample of patients with behavioural variant frontotemporal dementia (bvFTD). Methods: Data of 46 patients with bvFTD were employed in a hierarchical cluster analysis to determine the similarity of variance between different EF measures (verbal abstraction, verbal initiation, motor programming, sensitivity to interference, inhibitory control, visual abstraction, flexibility, working memory/attention) and ToM (faux pas). Results: Overall results showed that EF measures were clustered separately from the ToM measure. A post hoc analysis revealed a more complex picture where selected ToM subcomponents (empathy; intention) showed a relationship to specific EF measures (verbal abstraction; working memory/attention), whereas the remaining EF and ToM subcomponents were separate. Conclusions: Taken together, these findings suggest that EF and ToM are distinct components; however, ToM empathy and intention subcomponents might share some functions with specific EF processes. This has important implications for guiding diagnostic assessment of these deficits in clinical conditions

A child-centred exploration of the relevance of family and friends to theory of mind development

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 The Authors.Theory of Mind (ToM) is said to develop at around 4 years old. But some studies suggest it develops considerably earlier than this, with others suggesting it develops much later. Although several recent studies have found that social factors (like gender, family size, number of siblings, and number of friends) can impact on ToM, other studies contradict those findings. We wondered whether addressing several procedural issues and ensuring the task concerns real protagonists in real time, would bear on the above issues. Here, 114 children of 3–6 years completed four ToM tasks incorporating controls from experimental psychology, including randomly varying the order of ToM and non-ToM questions across participants. Now, children passed ToM tasks from around 5 years old, rather than 4 years or earlier. Girls did not develop ToM any earlier than boys. There was clear correlational evidence for the older-sibling effect and effects of friends but no reliable effects of nuclear or extended family. However, when these factors were set in the context of one another, the sibling effect was driven by a negative influence from younger siblings (as opposed to older siblings) and the friends effect was driven by friends at school (as opposed to friends at home). Finally, “friends” was a stronger predictor than siblings but memory (a cognitive factor) and age (a maturational factor) were the strongest predictors of all

Disordered Eating Habits, Emotion Regulation, and Theory of Mind in Undergraduate Students

Theory of Mind (ToM), the ability to recognize and attribute mental states to oneself and others, has been found to be impaired in a number of different psychological disorders (Bora et al. 2009). Evaluating ToM in a population suffering from eating disorders, however, has proven less consistent; some Anorexia Nervosa patients show ToM deficits compared to healthy controls (Russell et al. 2009) and others perform similarly (Tchanturia et al. 2004). A common consensus not only seems to be lacking within the literature on ToM and Anorexia Nervosa, but within the broader family of eating disorders as well (e.g., Bulimia Nervosa; Medina-Pradas et al. 2012). Furthermore, due to a lack of research, it remains unclear how ToM relates to dysfunctional eating habits that don’t meet DSM-5 criteria for an eating disorder. The role of emotion regulation (ER) appears promising in accounting for some of these discrepancies. The current thesis hypothesized first that ToM would be correlated with higher eating disorder symptomology and second that ER would mediate the relationship between ToM abilities and eating disorder symptomology. Neither of the current hypotheses were supported. However, an exploratory analysis revealed significant relationships between the eating disorder measures used and specific subscales of the DERS (between the RS and the lack of emotional awareness/limited access to strategies subscales and between the EA and nonacceptance of emotions subscale). Implications for future research and application to treatment are discussed

It\u27s My Centennial! said Tom Swiftly

Starting in 1910, boys grew up devouring the adventures of Tom Swift, a sterling hero and natural scientific genius created by Edward Stratemeyer. Many of Tom\u27s inventions predated technological developments in real life -- electric cars, seacopters, and houses on wheels. In fact, some say that the Tom Swift tales laid the groundwork for American science fiction

Those Who Give: Healthy Lung, Generous Hearts: Tom and Felice Wiener

Last March, Tom Wiener’s physicians noticed a small lump on the side of his neck. Tom dutifully followed through with a CT scan at his community hospital. While the scan confirmed that the lump in his neck was nothing to worry about, it also revealed something more suspicious in the upper part of his right lung. As Tom recalls, the physicians said it could be one of two things – a tumor or an infection. After two follow-up tests, Tom and his wife, Felice, received the frightening diagnosis: lung cancer. Referred to Jefferson, Tom soon met Scott W. Cowan, MD, FACS, at Methodist Hospital. Dr. Cowan told him that many of his patients undergo operations on “incidental findings” like his. In early May, Dr. Cowan performed a minimally invasive lobectomy to remove the tumor from Tom’s lung – and he made a full recovery without the need for radiation or chemotherapy. “Fortunately, it turned out to have been a slow-growing adenocarcinoma. It was the size of a golf ball and totally self-contained,” says Tom, who lives in Wynnewood and practices law in Bala Cynwyd, PA. In reflecting on his experiences as a patient, Tom lauds Dr. Cowan both for his surgical prowess and his warm personality.“Scott and the entire Jefferson team took great care of me,” Tom says. “I’m very grateful; they did a wonderful job.” When presented with the opportunity to make a contribution to the Department of Surgery, Tom and Felice were happy to support Dr. Cowan’s efforts as Jefferson’s NSQIP (National Surgical Quality Improvement Program) Surgeon Champion. The Wieners’ generous gift is helping to offset the cost of Dr. Adam Johnson’s two-year Quality and Safety Fellowship – the first of its kind at Jefferson (see cover story). Both say they plan to continue contributing as long as they are able. Felice is thankful to Dr. Cowan “because he did such a good job with my sweet husband” – and she says she already had good memories of Jefferson, having given birth to one of the couple’s four children at Jefferson some 40 years ago. These days, the Wieners are enjoying good health and an extra special “gift” from their daughter: their third grandchild (and the first to live nearby). For information about making a contribution to the Department of Surgery, please contact Lara GoldStein in the Jefferson Office of Institutional Advancement at 215-955-8797 or [email protected]