400 research outputs found
Jamming Effects on Hybrid Multistatic Radar Network Range and Velocity Estimation Errors
This research studies the effects of three noise jamming techniques on the performance of a hybrid multistatic radar network in a selection of different electronic warfare (EW) situations. The performance metrics investigated are the range and velocity estimation errors found using the Cramér-Rao lower bounds (CRLBs). The hybrid multistatic network simulated is comprised of a single active radar transmitter, three illuminators of opportunity (IO), a receiver co-located at the active transmitter site, and two separately located silent receivers. Each IO transmits at a unique frequency band commonly used for civilian applications, including Digital Video Broadcasting-Terrestrial (DVB-T), Digital Audio Broadcasting (DAB), and FM radio. Each receiver is capable of receiving signals at all three IO frequency bands as well as the operating frequency band of the active radar transmitter. The investigations included compare the performance of the network at detecting a single flying target under conditions where different combinations of jammer type, operating mode, directivity, and number of jammers operating are used. The performance degradation of the system compared to operation in a non-contested environment is determined and a comparison between the performance of the hybrid multistatic radar with that achievable by a monostatic radar and an active-only multistatic radar network within a selection of contested scenarios is made. Results show that the use of spatially distributed nodes and frequency diversity within the system enable greater theoretical functionality in the presence of jamming over conventional radar systems
Decoding the protein-DNA recognition rules
The C2H2 zinc finger (ZF) transcription factors (TF) form the largest family of DNA binding proteins in eukaryotes. TFs are key proteins involved in gene regulation that bind to specific DNA sites. A major obstacle towards understanding the molecular basis of transcriptional regulation is the lack of a recognition code for protein-DNA interactions. We aim to understand molecular mechanisms of DNA recognition and to quantitatively estimate recognition rules for TF-DNA interactions. We identified key residues playing an important role in ZF-DNA interactions and found that they are prealigned to conformations observed in the bound state prior to binding. A binding site for Cl- ions corresponding to the pocket where DNA phosphates are found most buried in the complex of ZFs is identified. Bound ions constrain conformations of important residues consistent with observations of increased binding affinity with increased ionic strength in protein-DNA interactions. These results suggest a general mechanism where ZFs, through their key residues, rapidly form encounter complexes amenable for a fast readout of the DNA. We developed a novel experimentally-based approach using crystal structures and binding data on the C2H2 ZFs and decoded ten fundamental specific interactions for protein-DNA recognition. These are: Five hydrogen bonds, three desolvation penalties, a non-polar energy, and a novel water accessibility factor. The code is applied to three data sets with a total of 89 ZF mutants on three ZFs of EGR. Guided by simulations of individual ZFs, we mapped the interactions into homology models with all feasible intra- and inter- molecular bonds and selected the structure with the lowest free energy for each ZF. The interactions reproduce changes in affinity of 35 mutants of finger I (FI) (R2 = 0.99), 23 mutants of FII (R2 = 0.97) and 31 human ZFs on FIIII (R2 = 0.95). The method predicts bound ZF-DNA complexes for all mutants, decoding molecular basis of ZF-DNA specificity. These findings reveal recognition rules that depend on DNA sequence/structure, molecular water at the interface and induced fit of the C2H2 TFs. In summary, our method provides the first robust framework to decode the molecular basis of TFs binding to DNA
Examining Food Quality via RFID Tag Array
Radio-frequency identification (RFID) tags are widely used in the food supply chain where they can be used to hold identification data of tagged objects. They can also be used to provide information related to the quality and safety of the tagged object. This can be achieved by analyzing the RF signals emitted by the tag which couples with the tagged objects, and hence can be used to acquire useful information related to the safety and quality of that object. This paper investigates the correlation between the radiated signals from the tags and the quality characteristics of the tagged objects. It focuses on analyzing the mutual coupling between the tags in an array, in particular, of orthogonal polarization configuration, which shows that more information can be extracted by an array of tags compared to the use of a single RFID tag emitter
An Experimental Study of Radar-Centric Transmission for Integrated Sensing and Communications
This study proposes a dual-function radar and communication (DFRC) system that utilizes radar transmission parameters as modulation indexes to transmit data to the users while performing radar sensing as its primary function. The proposed technique exploits index modulation (IM) using the center frequency of radar chirps, their bandwidths, and polarization states as indexes to modulate the communication data within each radar chirp. By utilizing the combination of these indexes, the proposed DFRC system can reach up to 17 Mb/s throughput, while observing a robust radar performance. Through our experimental study, we also reveal the trade-off between the radar sensing performance and communication data rate, depending on the radar waveform parameters selected in the DFRC system. This study also demonstrates the implementation of the proposed DFRC system and presents its real-time over-the-air experimental measurements. Consequently, the simulation results are verified by real-time over-the-air experiments, where ARESTOR, a high-speed signal processing and experimental radar platform, has been employed
Calibration of Aperture Arrays in Time Domain Using the Simultaneous Perturbation Algorithm
Online calibration is desired in antenna arrays of ultrawide bandwidth. This study proposes a time domain calibration method based on the simultaneous perturbation algorithm. Two objective functions were established: power of the received signal at array output; or combination of power and correlation coefficient between the signal at array output and a target signal. For both criteria, the convergence settings require only two measurements at each iteration. One advantage of the method is that the entire signal operation for calibration is performed in the time domain. This is achieved by resolving the effects of distortion on time delay of each channel, which accounts for both amplitude and phase distortions at different frequencies. Therefore, the proposed method significantly increased the calibration efficiency for ultra-wideband antenna arrays. Since time delay coefficients for calibration associated with array elements were determined independently due to characteristic of the simultaneous perturbation, estimation accuracy of the method is tangential to the number of elements in the array, and is mainly dependent on the convergence conditions. This gives the method an additional distinct advantage for calibrating large-scale antenna arrays with ultrawide bandwidth. An estimation accuracy of 99% on time delay adjustments has been achieved and demonstrated
Equivalent Circuit of Metamaterial Formed by Array of Conductive Disks
The use of metamaterials to obtain a wideband wide angle impedance matching (WAIM) for compact phased array of interconnected crossed rings is investigated. The metamaterial layer above the planar array is formed by array of conductive disks in contrast to the conventional multilayer homogeneous dielectric structure. The equivalent circuit of the metamaterial layer to enhance wideband array antenna design is derived based on a hybrid technique. The values of the components in the equivalent circuit to represent metamaterial layer is given. The response from the equivalent circuit is verified by using the full-wave numerical simulations on the metamaterial structure. The results show the effectiveness of the method in analyzing the electromagnetic characteristics of the structure and improving the performance of the whole array system
In-House Made Inverted Microstrip Line Phase Shifter Based on Nematic Liquid Crystal
Nematic liquid crystals are anisotropic dielectrics whose properties could be controlled by surface anchoring, exter-nal electric or magnetic fields. A typical design method of tunable inverted microstrip line phase shifter based on liquid crystal for microwave application is investigated. Two phase shifter designs based on the proposed method were introduced with the center operation frequency of 10 GHz and 20 GHz respectively. The prototype design operating at 20GHz is manufactured. The dielectric anisotropy of the liquid crystal used for the prototype is 0.45. A differential phase shift of 27.2° was achieved at 20 GHz with the physical length of 20 mm, connected to two coplanar waveguide ports of 50 ohms through vias, and under an external bias of 7 V
3D Architecture and Replaceable Layers for Label-Free DNA Biochips
Recent advances in bio-sensing technologies have led to design of bio-sensor arrays for rapid identification and quantification of various biological agents such as drugs, gene expressions, proteins, cholesterol, fats, etc. Various dedicated sensing arrays are already available commercially to monitor some of these compounds in a sample. However, monitoring the simultaneous presence of multiple agents in a sample is still a challenging task. Multiple agents may often attach to the same probes on an array which makes it difficult to design a chip that can distinguish such agents (leading to low specificity). Thus, sophisticated algorithms for targets identification need to be implemented in biochip in order to maximize the number of distinguishable targets in the samples. The proposed algorithms are also required to introduce sophisticated signal processing and more intelligence on-chip. Dealing with these new processing and information technology demands constraints also require more innovative approaches towards hybrid integration technologies. To address such new demands, we discuss in this paper an innovative 3D-integrated bio-chips especially dedicated to label-free DNA detection
Minimising the impact of disturbances in future highly-distributed power systems
It is expected that future power systems will require radical distributed control approaches to accommodate the significant expansion of renewable energy sources and other flexible grid devices. It is important to rapidly and efficiently respond to disturbances by, for example: utilising adaptive, wide-area protection schemes; proactive control of available grid resources (such as managing the fault level contribution from converter-interfaced generation) to optimise protection functionality; and taking post-fault action to ensure protection stability and optimal system operation. This paper analyses and highlights the protection functions which will be especially important to minimising the impact of disturbances in future power systems. These functions include: fast-acting wide-area protection methods using Phasor Measurement Units (PMUs); adaptive and “self-organising” protection under varying system conditions; protection with distributed Intelligent Electronic Devices (IEDs); enhanced fault ride-through; and pattern recognition based schemes. In particular, the paper illustrates how the increased availability of measurements and communications can enable improved protection functionality within distribution systems, which is especially important to accommodate the connection of highly-distributed generation at medium- and low-voltages
Comparison of inflammatory biomarkers for detection of coronary stenosis in patients with stable coronary artery disease
Erdogan, Turan/0000-0003-2986-5457; Cetin, Mustafa/0000-0001-6342-436X; yilmaz, adnan/0000-0003-4842-1173WOS: 000319223400015PubMed: 23329531BACKGROUND: the objective of the current study was to evaluate the role of various inflammatory biomarkers in detection of coronary stenosis in patients with stable coronary artery disease (CAD) and healthy people. METHODS: A total of 111 patients with stable coronary artery disease, and 66 healthy subjects were enrolled in the study. Serum levels of lipoprotein-associated-phospholipase A2 (Lp-PLA(2)), high-sensitivity C-reactive protein (hs-CRP), and myeloperoxidase (MPO) were measured to compare patient and control groups. RESULTS: Baseline characteristics were similar between healthy and patient groups, with the exception of age. ANCOVA and log-transformed data of inflammatory biomarkers revealed that, Lp-PLA(2) (p < 0,001) and hs-CRP (p < 0,05) levels in all patient groups were significantly higher than in the control group. Conversely, there was no significant difference in MPO levels among groups. CONCLUSIONS: in stable CAD patients, serum Lp-PLA(2) levels are more compatible than hsCRP and MPO levels in the detection of coronary stenosis.PfizerPfizer; ServierServier; Astra ZenecaAstraZenecaThis study was supported by the drug companies Pfizer, Servier and Astra Zeneca. the Authors thank all of the companies that helped during this investigation
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