Understanding factors associated with the translation of cardiovascular research: A multinational case study approach

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.This article has been made available through the Brunel Open Access Publishing Fund.Background: Funders of health research increasingly seek to understand how best to allocate resources in order to achieve maximum value from their funding. We built an international consortium and developed a multinational case study approach to assess benefits arising from health research. We used that to facilitate analysis of factors in the production of research that might be associated with translating research findings into wider impacts, and the complexities involved. Methods: We built on the Payback Framework and expanded its application through conducting co-ordinated case studies on the payback from cardiovascular and stroke research in Australia, Canada and the United Kingdom. We selected a stratified random sample of projects from leading medical research funders. We devised a series of innovative steps to: minimize the effect of researcher bias; rate the level of impacts identified in the case studies; and interrogate case study narratives to identify factors that correlated with achieving high or low levels of impact. Results: Twenty-nine detailed case studies produced many and diverse impacts. Over the 15 to 20 years examined, basic biomedical research has a greater impact than clinical research in terms of academic impacts such as knowledge production and research capacity building. Clinical research has greater levels of wider impact on health policies, practice, and generating health gains. There was no correlation between knowledge production and wider impacts. We identified various factors associated with high impact. Interaction between researchers and practitioners and the public is associated with achieving high academic impact and translation into wider impacts, as is basic research conducted with a clinical focus. Strategic thinking by clinical researchers, in terms of thinking through pathways by which research could potentially be translated into practice, is associated with high wider impact. Finally, we identified the complexity of factors behind research translation that can arise in a single case. Conclusions: We can systematically assess research impacts and use the findings to promote translation. Research funders can justify funding research of diverse types, but they should not assume academic impacts are proxies for wider impacts. They should encourage researchers to consider pathways towards impact and engage potential research users in research processes. © 2014 Wooding et al.; licensee BioMed Central Ltd.RAND Europe and HERG, with subsequent funding from the NHFA, the HSFC and the CIHR. This research was also partially supported by the Policy Research Programme in the English Department of Health

Transforming U.S. agriculture with crushed rock for CO2_2 sequestration and increased production

Enhanced weathering (EW) is a promising modification to current agricultural practices that uses crushed silicate rocks to drive carbon dioxide removal (CDR). If widely adopted on farmlands, it could help achieve net-zero or negative emissions by 2050. We report detailed state-level analysis indicating EW deployed on agricultural land could sequester 0.23-0.38 Gt CO$_2$ yr$^{-1}$ and meet 36-60 % of U.S. technological CDR goals. Average CDR costs vary between state, being highest in the first decades before declining to a range of $\sim\$$100-150 tCO$_2{}^{-1}$ by 2050, including for three states (Iowa, Illinois, and Indiana) that contribute most to total national CDR. We identify multiple electoral swing states as being essential for scaling EW that are also key beneficiaries of the practice, indicating the need for strong bipartisan support of this technology. Assessment the geochemical capacity of rivers and oceans to carry dissolved EW products from soil drainage suggests EW provides secure long-term CO$_2$ removal on intergenerational time scales. We additionally forecast mitigation of ground-level ozone increases expected with future climate change, as an indirect benefit of EW, and consequent avoidance of yield reductions. Our assessment supports EW as a practical innovation for leveraging agriculture to enable positive action on climate change with adherence to federal environmental justice priorities. However, implementing a stage-gating framework as upscaling proceeds to safeguard against environmental and biodiversity concerns will be essential

Does Strategic Planning Improve Organizational Performance? A Meta-Analysis

Strategic planning is a widely adopted management approach in contemporary organizations. Underlying its popularity is the assumption that it is a successful practice in public and private organizations that has positive consequences for organizational performance. Nonetheless, strategic planning has been criticized for being overly rational and for inhibiting strategic thinking. This article undertakes a meta-analysis of 87 correlations from 31 empirical studies and asks, Does strategic planning improve organizational performance? A random-effects meta-an

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Fiscal policy and ecological sustainability: a post-Keynesian perspective

Fiscal policy has a strong role to play in the transition to an ecologically sustainable economy. This paper critically discusses the way that green fiscal policy has been analysed in both conventional and post-Keynesian approaches. It then uses a recently developed post-Keynesian ecological macroeconomic model in order to provide a comparative evaluation of three different types of green fiscal policy: carbon taxes, green subsidies and green public investment. We show that (i) carbon taxes reduce global warming but increase financial risks due to their adverse effects on the profitability of firms and credit availability; (ii) green subsidies and green public investment improve ecological efficiency, but their positive environmental impact is partially offset by their macroeconomic rebound effects; and (iii) a green fiscal policy mix derives better outcomes than isolated policies. Directions for future heterodox macroeconomic research on the links between fiscal policy and ecological sustainability are suggested

Making better use of information to drive improvement in local public services: A report for the Audit Commission

This report on making better use of information to drive improvement in local public services was commissioned from the School of Public Policy at the University of Birmingham, by the Audit Commission. It explores how decision makers use information when making decisions. These decision makers can be politicians, top managers, operational managers, planners etc. The focus of this report is not on the use of performance indicators sensu stricto, but on the use of information more generally. Rather than studying how existing information is used or not used in decision making, this report is looking at how decision makers go about searching, analysing, summarising, processing and interpreting information when they need to make a decision. The report consists of three main chapters. - A summary of key government policy initiatives in the UK to stimulate the use of information in decision making - A review of the relevant research literature. This is the main section of the report. In it, we review the role of information in decision making theories, the organisational and structural context of information use, and psychological factors in the use of information in decision making - A presentation of a number of international perspectives on the use of information in public sector decision makin