REVIEW OF TRADITIONAL USE, PHARMACOLOGICAL EFFECTS AND TOXICITY OF MEDICINAL PLANTS FOR WOMEN'S HEALTH IN INDONESIA

The aim of this review is to provide inspiration for research in  traditional use, pharmacological effects and toxicity of medicinal plants for women's  health   in Indonesia. Punica granatum L, Coriandrum sativum L, Elephantopus scaber L, Foeniculum vulgare M, Kaempferia galanga L, Nigella sativa L are herbs often used as medicinal plants for women's health care such as pregnancy's disorders, leucorrhoea, menstrual disorders, aphrodisiac, natural contraception, care during childbirth, lactagogum, body and skin beauty care. The medicinal plants are often consumed directly or mixed in jamu/herbal medicine. Many research reported regarding the pharmacological effect and toxicity test of medicinal plants. This review will show the traditional use, pharmacological effect, and toxicity of Punica granatum, Coriandrum sativum, Elephantopus scaber, Foeniculum vulgare, Kaempferia galanga, Nigella sativa.Keywords: Punica granatum, Coriandrum sativum, Elephantopus scaber, Foeniculum vulgare, Kaempferia galanga, Nigella sativ

Isolasi, Karakterisasi Dan Uji Aktivitas Pencegahan Antikalkuli Luteolin 7-o-glukosida Dari Daun Sonchus Arvensis L., Pada Tikus Dengan Metode Matriks-asam Glikolat

Banyak tumbuhan yang digunakan untuk mengobati penyakit batu kandungkemih dalam pengobatan tradisional Indonesia. Diantaranya: Orthosiphonaristatus (Bl.)Miq., Sonchus arvensis L., Phyllanthus niruri L., Strobilanthus crispusL. dan Imperata cylindrica L., Sonchus arvensis L. telah diteliti efek antikalkulinyaterhadap batu oksalat kandung kemih eksperimental pada tikus jantan.Kandungan kimia yang telah diketahui yaitu asam fenolat dan turunannya,flavonoid (antara lain luteolin 7-O-glukosida), terpena, kumarin, lipid dan minyakatsiri. Senyawa luteolin 7-O-glukosida telah diisolasi dari ekstrak etanol dandikarakterisasi dengan spektrofotometri ultraviolet, inframerah, massa danresonansi magnet inti. Uji aktivitas antikalkuli luteolin 7-O-glukosida dilakukandengan metode matriks-asam glikolat. Bobot batu kandung kemih yang terjadidigunakan sebagai parameter untuk mengevaluasi aktivitas antibatu kandungkemih. Dari penelitian diperoleh, luteolin 7-O-glukosida aktif sebagai antikalkulipada dosis 0,15 mg/kg bb tikus: pada upaya pencegahan berkhasiat 51,62%(P≤0,05) dan pada upaya pengobatan, terjadi penekanan 3,77% walaupunsecara statistik tidak bermakna

BRINE SHRIMP TERATOGENIC SCREENING TEST ON SOME SELECTED PLANTS

  Objectives: The aims of this research were to analyze teratogenic properties on some selected plants which often used for woman's health were pomegranate (Punica granatum L.) pericarp, coriander (Coriandrum sativum L.) seeds, liman (Elephantopus scaber L.) leaves, fennel (Foeniculum vulgare M.) seeds, and kaempferia (Kaempferia galanga L.) rhizomes using brine shrimp teratogenic screening test (BSTST) method.Methods: Artemia cysts were hatched into first stage nauplii then taken and put into seawater medium which contain test substance and kept alive until the second stage, third stage, and fourth stage and then observed number of deaths, morphological abnormalities, body length, and retarded of development for each stage.Results: Hatchability of cysts in fennel seeds compared extracts 1 and 0.5 mg/ml, coriander seeds extract 1 mg/ml, pomegranate rinds extract 6 mg/ml, and liman leaves extracts 6, 3, and 1.5 mg/ml were significantly different to control (p<0.05). Survival nauplii in fennel seeds extracts 1 and 0.5 mg/ml and liman leaves extracts 6 and 3 mg/ml were significantly different to control (p<0.05). The morphological abnormalities were exposed on coriander seeds extract 1 mg/ml, liman leaves extract 6 mg/ml, and pomegranate rinds extract 3 mg/ml. Nauplii with retarded development were presented on fennel seeds extracts 1 and 0.5 mg/ml, coriander seeds extracts 1 and 0.25 mg/ml, pomegranate rinds extracts 6, 3, and 1.5 mg/ml, and liman leaves extracts 3 and 1.5 mg/ml. Nauplii body length on plants extract showed no significantly difference compared to control.Conclusion: Based on BSTST, fennel seed and pomegranate rind extracts had no teratogenic effect, kaempferia rhizomes act as larvicide its analog in mamalia as embryo lethal, while coriander seeds and liman leaves extracts potentially had teratogenic properties

Review: Study the Role of China Acupuncture and "GI" Acupuncture as an Alternative and Complementary Therapy in the Treatment

This article discusses the scientific literature review on Chinese acupuncture and "GI"  acupuncture as an attempt therapy many cases, besides that specifically studied the effectiveness of traditional acupuncture china to stress with "GI" acupuncture. Chinese acupuncture is an acupuncture method that was developed in China since ± 2000 years ago, while "GI" acupuncture is a method of acupuncture that was developed at the Institute Technology Bandung by acupuncturists Gunawan Ismail (Alm) is slightly different from the traditional Chinese acupuncture, where acupuncture "GI "based on a 7 acupuncture points on the body for ase points determined based of Java massage. Each method studied acupuncture and its role as a therapeutic efforts on a variety of cases, and the results of the study showed some success in handling cases of diseases such as fibromyalgia, stroke and stress. The role of acupuncture GI who want to see here is give the same effectiveness with traditional acupuncture originated from China or even better

Pharmacological Activities of Three Kinds “Kayu kuning”: Arcangelisia flava, Fibraurea tinctoria, and Coscinium fenestratum – an Short Review

The literature-based review was constructed discussing three types of yellow woods plant from Indonesia, including Arcangelisia flava, Fibraurea tinctoria, and Coscinium fenestratum. Yellow wood plants are widely used as traditional medicine due to its activities that were pharmacologically studied. Those activities include antiplasmodial, cytotoxic, antioxidant, toxicity, antidiabetic, anticolestroleia, antihypertensive to liver activity, and health-behavior changes in experimental animals

Aktivitas Ekstrak Ethanol Daun, Ranting, dan Kulit Buah Manggis (Garcinia mangostana l.) sebagai Tabir Surya secara in vitro

Telah banyak penelitian yang dilakukan pada buah Manggis (Garcinia mangostana L.) , kayu maupun kulit buahnya sebagai pengobatan, antara lain diare, antiinflamasi, HIV. Hal ini sehubungan dengan kandungan manggis yang beragam. Zat aktif yang terkandung dalam manggis sangat banyak antara lain tanin, xanthone dan bensofenon glukosida yaitu garmacimangasone D. Kandungan turunan bensofenone diduga mempunyai aktivitas sebagai tabir surya. Dari penelitian sebelumnya telah diketemukan turunan bensofenone dalam kulit buah manggis dan kayunya. Turunan bensofenone telah dimanfaatkan sebagai tabir surya pada sediaan kosmetika, dengan demikian diharapkan turunan bensofenon yang ada dalam manggis (Garcinia mangostana L.) mempunyai juga aktivitas sebagai tabir surya. Pada penelitian ini dilakukan uji aktivitas tabir surya pada daun, ranting, dan kulit buah manggis. Mula-mula dilakukan ekstraksi maserasi dengan menggunakan etanol pada simplisia daun, ranting, dan kulit buah manggis. Penetapan ekstrak aktifitas tabir surya yaitu dengan menggunakan spektrofotometer pada panjang gelombang 290 hingga 400 nm menggunakan pelarut etanol. Dari peneltian yang telah dilakukan nilai sun protection factor (SPF) ekstrak kulit buah, ranting, dan daun manggis pada konsentrasi 50 μg/ ml adalah 1,967 (pada panjang gelombang 290-382,5 nm); 1,356 (290-332,5 nm) ; 1,286 (290-327.5 nm). Dengan demikian ekstrak kulit buah manggis mempunyai SPF yang relatif lebih tinggi dibanding ranting maupun daunnya

THE CAPABILITY OF BRINE SHRIMP TEST AS A TERATOGENICITY SCREENING SYSTEM

ABSTRACTObjectives: The goals of this study were to analyze the capability of brine shrimp test (BST) as a potent teratogenicity screening system on teratogenicagents (methotrexate, captopril, diclofenac, phenytoin, warfarin, and valproic acid).Methods: Artemia cysts were hatched into 1st stage nauplii, then taken and put into seawater medium which contain test substance and kept alive until2nd stage, 3rd stage, and 4th stage, and number of deaths, morphological abnormalities, body length, and retarded of development were observed for each stage.Results: Hatch ability of cysts in methotrexate 0.015 mg/ml, captopril 0.25 mg/ml, diclofenac 0.075 mg/ml, phenytoin 1.56 mg/ml, and valproic acid2.5 mg/ml were significantly different compared to control (p<0.05). Nauplii survival in methotrexate 0.015 mg/ml, captopril 0.25 mg/ml, diclofenac0.075 mg/ml, phenytoin 1.56 mg/ml, and valproic acid 2.5 mg/ml were significantly different to control (p<0.05). The morphological abnormalitieswas found in methotrexate 0.015 mg/ml, captopril 0.25 mg/ml. Nauplii with retarded development were expressed in methotrexate 0.015 mg/ml,captopril 0.25 mg/ml, diclofenac 0.075 mg/ml, phenytoin 1.56 mg/ml, and valproic acid 2.5 mg/ml. Significant difference in body length was presentedin captopril 0.25 mg/ml, and phenytoin 1.56 mg/ml compared to control (p<0.05).Conclusion: BST can be used as an alternative method of the teratogenic screening test, although not as sensitive teratogenic tests on mammals. Thisscreening method was not suitable for a compound which its chemical characteristic can change the tonicity of the medium.Keywords: Brine shrimp test, Teratogenicity, Methotrexate, Captopril, Diclofenac, Phenytoin, Warfarin, Valproic acid

ISOLASI, KARAKTERISASI DAN UJI AKTIVITAS PENCEGAHAN ANTIKALKULI LUTEOLIN 7-O-GLUKOSIDA DARI DAUN Sonchus arvensis L., PADA TIKUS DENGAN METODE MATRIKS-ASAM GLIKOLAT

Banyak tumbuhan yang digunakan untuk mengobati penyakit batu kandungkemih dalam pengobatan tradisional Indonesia. Diantaranya: Orthosiphonaristatus (Bl.)Miq., Sonchus arvensis L., Phyllanthus niruri L., Strobilanthus crispusL. dan Imperata cylindrica L., Sonchus arvensis L. telah diteliti efek antikalkulinyaterhadap batu oksalat kandung kemih eksperimental pada tikus jantan.Kandungan kimia yang telah diketahui yaitu asam fenolat dan turunannya,flavonoid (antara lain luteolin 7-O-glukosida), terpena, kumarin, lipid dan minyakatsiri. Senyawa luteolin 7-O-glukosida telah diisolasi dari ekstrak etanol dandikarakterisasi dengan spektrofotometri ultraviolet, inframerah, massa danresonansi magnet inti. Uji aktivitas antikalkuli luteolin 7-O-glukosida dilakukandengan metode matriks-asam glikolat. Bobot batu kandung kemih yang terjadidigunakan sebagai parameter untuk mengevaluasi aktivitas antibatu kandungkemih. Dari penelitian diperoleh, luteolin 7-O-glukosida aktif sebagai antikalkulipada dosis 0,15 mg/kg bb tikus: pada upaya pencegahan berkhasiat 51,62%(P≤0,05) dan pada upaya pengobatan, terjadi penekanan 3,77% walaupunsecara statistik tidak bermakna