Baseline tests of the EPC Hummingbird electric passenger vehicle

The rear-mounted internal combustion engine in a four-passenger Volkswagen Thing was replaced with an electric motor made by modifying an aircraft generator and powered by 12 heavy-duty, lead-acid battery modules. Vehicle performance tests were conducted to measure vehicle maximum speed, range at constant speed, range over stop-and-go driving schedules, maximum acceleration, gradeability limit, road energy consumption, road power, indicated energy consumption, braking capability, battery charger efficiency, and battery characteristics. Test results are presented in tables and charts

Running across the Silurian/Devonian Boundary along Northern Gondwana: A Conodont Perspective

The Global Stratotype Section and Point (GSSP) of the Silurian/Devonian boundary, Lower Devonian Series and Lochkovian Stage was formally placed in 1977 at Klonk, in the Czech Republic, at the first appearance of the graptolite Uncinatograptus uniformis uniformis (Přibyl). However, since then, correlation of this limit has been often hampered in carbonate facies where graptolites are uncommon or totally absent. A large calcareous deposition occurred at the Silurian/Devonian boundary along the northern and peri-Gondwana margin, thus representing an ideal location to select and test a possible additional biostratigraphic marker of the limit among conodonts. The first appearance of Caudicriodus hesperius almost simultaneously at the base of the Devonian in Bohemia, the Carnic Alps, Sardinia, Morocco and elsewhere indicates that this taxon is the conodont that best approximates the beginning of the Period. The first or last appearance of other species (e.g., Ozarkodina confluens, Zieglerodina klonkensis, Z. remscheidensis and Caudicriodus woschmidti) may help to recognise the boundary as well

Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures

BACKGROUND: Interfollicular skin develops normally only when the activity of the progenitor cells in the basal layer is counterbalanced by the exit of cells into the suprabasal layers, where they differentiate and cornify to establish barrier function. Distinct stem and progenitor compartments have been demonstrated in hair follicles and sebaceous glands, but there are few data to describe the control of interfollicular progenitor cell activity. Wnt signaling has been shown to be an important growth-inducer of stem cell compartments in skin and many other tissues. RESULTS: Here, we test the effect of ectopic Wnt1 expression on the behavior of interfollicular progenitor cells in an organotypic culture model, and find that Wnt1 signaling inhibits their growth and promotes terminal differentiation. CONCLUSION: These results are consistent with the phenotypes reported for transgenic mice engineered to have gain or loss of function of Wnt signaling in skin, which would recommend our culture model as an accurate one for molecular analysis. Since it is known that canonical ligands are expressed in skin, it is likely that this pathway normally regulates the balance of growth and differentiation, and suggests it could be important to pathogenesis

Optimization of cascaded regenerative links based on phase sensitive amplifiers

We develop an analytical method for optimizing phase sensitive amplifiers for regeneration in multilevel phase encoded transmission systems. The model accurately predicts the optimum transfer function characteristics and identifies operating tolerances for different signal constellations and transmission scenarios. The results demonstrate the scalability of the scheme and show the significance of having simultaneous optimization of the transfer function and the signal alphabet. The model is general and can be applied to any regenerative system

Long‐Term Responses Of The Kuparuk River Ecosystem To Phosphorus Fertilization

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117218/1/ecy2004854939.pd

Technische Grundlagen der Beschallung von Räumen

Jegliche Form der Beschallung, von kleinen Einbaulautsprechern im Auto bis zu großvolumigen Line Array Systemen in Sportstadien oder bei Open Air Events mit 100.000 Zuhörern, benötigt ein elektroakustisches Wandlersystem, d. h. ein Gerät, das elektrische Energie in Schallwellen verwandelt. Die Eigenschaften des damit aufgebauten Lautsprechers hängen vom physikalischen Prinzip und von der Konstruktion des Wandlers (auch als Treiber bezeichnet) ebenso ab wie von seinem Einbau in ein Gehäuse und der vorgeschalteten Elektronik. Sobald mehr als ein einzelner Lautsprecher betrieben wird, ergeben sich die Eigenschaften der Beschallungsanlage als Ganzes daraus, wie verschiedene Lautsprecher zusammenwirken, um in einem mehr oder weniger ausgedehnten Hörbereich einen gut ausbalancierten Höreindruck zu erreichen. Dies reicht von der zweikanaligen Stereo-Wiedergabe bis zu Systemen mit mehreren Hundert Lautsprechern und entsprechend komplexer Signalverteilung. Dieser Systematik folgt der Aufbau des Kapitels, das zunächst den Aufbau eines einzelnen Lautsprechers behandelt, um in einem zweiten Abschnitt auf Prinzipien beim Zusammenwirken mehrerer Lautsprecher einzugehen, die man je nach Anwendung als Wiedergabeverfahren oder als Beschallungstechnik bezeichnen kann

Experimental demonstration of an optical differentiator based on a fiber Bragg grating in transmission

We report the first experimental demonstration of single transmissive fiber Bragg grating implementation of a first-order optical differentiation. The device has been designed and fabricated, and the experimental results show a good performance over an operational bandwidth of ∼2 nm

Simple geometric interpretation of signal evolution in phase-sensitive fibre optic parametric amplifier

Visualisation of complex nonlinear equation solutions is a useful analysis tool for various scientific and engineering applications. We have re-examined the geometrical interpretation of the classical nonlinear four-wave mixing equations for the specific scheme of a phase sensitive one-pump fiber optical parametric amplification, which has recently attracted revived interest in the optical communications due to potential low noise properties of such amplifiers. Analysis of the phase portraits of the corresponding dynamical systems provide valuable additional insight into field dynamics and properties of the amplifiers. Simple geometric approach has been proposed to describe evolution of the waves, involved in phase-sensitive fiber optical parametric amplification (PS-FOPA) process, using a Hamiltonian structure of the governing equations. We have demonstrated how the proposed approach can be applied to the optimization problems arising in the design of the specific PS-FOPA scheme. The method considered here is rather general and can be used in various applications

Combination of optison with ultrasound and electroporation increases albumin and thrompoietin transgene expression whilst elongation factor promoter prolongs its duration

Hypoalbuminaemia and thrombocytopaenia are two clinical problems frequently encountered in patients with chronic liver failure or cancer following treatment with chemotherapy. The current study was designed to assess the magnitude and duration of thrombopoietin and albumin transgene expression hoping to increase the production of albumin and platelets. Immunocompetent and immunocompromised (nude) mice were injected intramuscularly with plasmids expressing either human serum albumin or human thrombopoietin. The therapeutic expression cassette of the plasmids was driven by either CMV or elongation factor 1- promoters respectively. In order to achieve muscle specific expression both gene constructs included the myosin light chain enhancer. The experiment was conducted in a group of mice which were injected with the transgene plasmid either in normal saline or plasmid followed by electroporation, ultrasound, optison and a combination of all three to increase transgene expression. The result showed that plasmids with the CMV promoter induced the highest transgenic expression lasting for one week whilst plasmids with the elongation factor 1-alpha promoter produced a weaker expression lasting for a longer and more stable duration of expression up to 3 months in both immunocompetent and nude mice. The combination of electroporation and ultrasound with Optison TM provided the highest transgene expression. We concluded that it would be possible to increase albumin and platelets production by an intramuscular injection of plasmids expressing human albumin and thromopoietin. A combination of electroporation and ultrasound with Optison TM can increase their expression