Helicity-1/2 Mode as a Probe of Interactions of Massive Rarita-Schwinger Field

We consider the electromagnetic and gravitational interactions of a massive Rarita-Schwinger field. Stueckelberg analysis of the system, when coupled to electromagnetism in flat space or to gravity, reveals in either case that the effective field theory has a model-independent upper bound on its UV cutoff, which is finite but parametrically larger than the particle's mass. It is the helicity-1/2 mode that becomes strongly coupled at the cutoff scale. If the interactions are inconsistent, the same mode becomes a telltale sign of pathologies. Alternatively, consistent interactions are those that propagate this mode within the light cone. Studying its dynamics not only sheds light on the Velo-Zwanziger acausality, but also elucidates why supergravity and other known consistent models are pathology-free.Comment: 18 pages, cutoff analysis improved, to appear in PR

Inconsistencies of Massive Charged Gravitating Higher Spins

We examine the causality and degrees of freedom (DoF) problems encountered by charged, gravitating, massive higher spin fields. For spin s=3/2, making the metric dynamical yields improved causality bounds. These involve only the mass, the product eM_P of the charge and Planck mass and the cosmological constant \Lambda. The bounds are themselves related to a gauge invariance of the timelike component of the field equation at the onset of acausality. While propagation is causal in arbitrary E/M backgrounds, the allowed mass ranges of parameters are of Planck order. Generically, interacting spins s>3/2 are subject to DoF violations as well as to acausality; the former must be overcome before analysis of the latter can even begin. Here we review both difficulties for charged s=2 and show that while a g-factor of 1/2 solves the DoF problem, acausality persists for any g. Separately we establish that no s=2 theory --DoF preserving or otherwise -- can be tree unitary.Comment: 25 pages, late

Partial Masslessness of Higher Spins in (A)dS

Massive spin s>=3/2 fields can become partially massless in cosmological backgrounds. In the plane spanned by m^2 and \Lambda, there are lines where new gauge invariances permit intermediate sets of higher helicities, rather than the usual flat space extremes of all 2s+1 massive or just 2 massless helicities. These gauge lines divide the (m^2,\Lambda) plane into unitarily allowed or forbidden intermediate regions where all 2s+1 massive helicities propagate but lower helicity states can have negative norms. We derive these consequences for s=3/2,2 by studying both their canonical (anti)commutators and the transmutation of massive constraints to partially massless Bianchi identities. For s=2, a Hamiltonian analysis exhibits the absence of zero helicity modes in the partially massless sector. For s=5/2,3 we derive Bianchi identities and their accompanying gauge invariances for the various partially massless theories with propagating helicities (+/-5/2,+/-3/2) and (+/-3,+/-2), (+/-3,+/-2,+/-1), respectively. Of these, only the s=3 models are unitary. To these ends, we also provide the half integer generalization of the integer spin wave operators of Lichnerowicz. Partial masslessness applies to all higher spins in (A)dS as seen by their degree of freedom counts. Finally a derivation of massive d=4 constraints by dimensional reduction from their d=5 massless Bianchi identity ancestors is given.Comment: 35 pages, LaTeX, uses slashed.sty, version to appear in Nucl. Phys.

Massive Spin 3/2 Electrodynamics

We study the general non-minimally coupled charged massive spin 3/2 model both for its low energy phenomenological properties and for its unitarity, causality and degrees of freedom behaviour. When the model is viewed as an effective theory, its parameters (after ensuring the correct excitation count) are related to physical characteristics, such as the magnetic moment g factor, by means of low energy theorems. We also provide the corresponding higher spin generalisation. Separately, we consider both low and high energy unitarity, as well as the causality aspects of our models. None (including truncated N=2 supergravity) is free of the minimal model's acausality.Comment: 23 pages, 1 figure, LaTeX and axodraw.sty, novel Majorana-type term included; results unaltere

Improved Xenobiotic Metabolism and Reduced Susceptibility to Cancer in Gluten-Sensitive Macaques upon Introduction of a Gluten-Free Diet

A non-human primate (NHP) model of gluten sensitivity was employed to study the gene perturbations associated with dietary gluten changes in small intestinal tissues from gluten-sensitive rhesus macaques (Macaca mulatta).Stages of remission and relapse were accomplished in gluten-sensitive animals by administration of gluten-free (GFD) and gluten-containing (GD) diets, as described previously. Pin-head-sized biopsies, obtained non-invasively by pediatric endoscope from duodenum while on GFD or GD, were used for preparation of total RNA and gene profiling, using the commercial Rhesus Macaque Microarray (Agilent Technologies),targeting expression of over 20,000 genes.When compared with normal healthy control, gluten-sensitive macaques showed differential gene expressions induced by GD. While observed gene perturbations were classified into one of 12 overlapping categories--cancer, metabolism, digestive tract function, immune response, cell growth, signal transduction, autoimmunity, detoxification of xenobiotics, apoptosis, actin-collagen deposition, neuronal and unknown function--this study focused on cancer-related gene networks such as cytochrome P450 family (detoxification function) and actin-collagen-matrix metalloproteinases (MMP) genes.A loss of detoxification function paralleled with necessity to metabolize carcinogens was revealed in gluten-sensitive animals while on GD. An increase in cancer-promoting factors and a simultaneous decrease in cancer-preventing factors associated with altered expression of actin-collagen-MMP gene network were noted. In addition, gluten-sensitive macaques showed reduced number of differentially expressed genes including the cancer-associated ones upon withdrawal of dietary gluten. Taken together, these findings indicate potentially expanded utility of gluten-sensitive rhesus macaques in cancer research