Hemorragia post-parto: embolización terapéutica

ResumenPaciente de 29 años, puérpera, que presenta importante hemorragia postparto, con comprimiso hemodinámioco, que no cede a los tratamientos gineco-obstétricos habituales. Por su condición de primiparidad se decide intentar terapia endovascular, efectuándose embolización selectiva de ramas cérvico-uterinas, lograndose detener el sangramiento en forma exitosa.Summary29 year old patient, which presents a major postpartum hemorrhage, with hemodynamic involvement, that did not respond to the usual obstetric-gynecological treatments. For its status of primiparity, it is decided to try endovascular theraphy; performing a selective embolization of cervical-uterine branches, that was successful

Um breve guia para as Humanidades Digitais

As digital methodologies, tools and skills become increasingly central to working in the humanities, questions concerning the foundations, project outcomes, evaluation and design have become urgent. The specifications provide a set of criteria to guide those actually working in the Digital Humanities, as well as those who are asked to evaluate and fund Digital Humanities researchers, projects, and initiatives

Novel loss-of-function variants in CDC14A are associated with recessive sensorineural hearing loss in Iranian and Pakistani patients

CDC14A encodes the Cell Division Cycle 14A protein and has been associated with autosomal recessive non-syndromic hearing loss (DFNB32), as well as hearing impairment and infertile male syndrome (HIIMS) since 2016. To date, only nine variants have been associated in patients whose initial symptoms included moderate-to-profound hearing impairment. Exome analysis of Iranian and Pakistani probands who both showed bilateral, sensorineural hearing loss revealed a novel splice site variant (c.1421+2T>C, p.?) that disrupts the splice donor site and a novel frameshift variant (c.1041dup, p.Ser348Glnfs*2) in the gene CDC14A, respectively. To evaluate the pathogenicity of both loss-of-function variants, we analyzed the effects of both variants on the RNA-level. The splice variant was characterized using a minigene assay. Altered expression levels due to the c.1041dup variant were assessed using RT-qPCR. In summary, cDNA analysis confirmed that the c.1421+2T>C variant activates a cryptic splice site, resulting in a truncated transcript (c.1414_1421del, p.Val472Leufs*20) and the c.1041dup variant results in a defective transcript that is likely degraded by nonsense-mediated mRNA decay. The present study functionally characterizes two variants and provides further confirmatory evidence that CDC14A is associated with a rare form of hereditary hearing loss

Las realizaciones de lo «arcaico» en el mundo ibérico

This joint paper presents the preliminar report of a French-Spanish team working on the implications of the so called «archaism» in the lberian Culture: concepts, historiagraphy and relationship with other Mediterranean areas. Outstanding topics are considered: Greek and Iberian bronzes, Orientalizing jewellery, local sculpture, pottery, iconography. etc. Different exchange and trade techniques between the Península and the East Mediterranean during the Orientalizing period is also analysed. Additional publications will be further preseniedSe presenta el informe preliminar elaborado por un equipo hispanofrancés sobre las implicaciones de lo llamado «arcaico» en la cultura ibérica: su concepto, su historiografia y su relación con otras columnas mediterráneas. Se tratan aspectos particulares: bronces griegos e ibéricos, joycria orientalizante, escultura local, cerámica, problemas iconográficos, etc. Se analizan también diferentes formas de comercio en época temprana con las áreas mediterráneas. El trabajo en equipo se desarrollará en el futuro

Association of ethnicity with multisystem inflammatory syndrome in children related to SARS-CoV-2 infection: an international case-referent study

Background: It has been suggested that children and infants can develop multisystem inflammatory syndrome in children (MIS-C) in response to a SARS-CoV-2 infection and that Black children are overrepresented among cases. The aim of the current study was to quantify the association between Black, Asian, or other non-White genetic background and COVID-19-related MIS-C in children and infants.Methods: Eight different research groups contributed cases of MIS-C, potentially related to SARS-CoV-2 infection. Several sensitivity analyses were performed, including additional data available from the literature. Analyses were stratified by geographical region.Results: Seventy-three cases from nine distinct geographical regions were included in the primary analyses. In comparison to White children, the relative risk for developing MIS-C after SARS-CoV-2 infection was 15 [95% confidence interval (CI): 7.1 to 32] for Black children, 11 (CI: 2.2 to 57) for Asian, and 1.6 (CI: 0.58 to 4.2) for other ethnic background.Conclusion: Pediatricians should be aware of the fact that the risk of COVID-19-related MIS-C is severely increased in Black children.Prevention, Population and Disease management (PrePoD)Public Health and primary car