Contextual Motifs: Increasing the Utility of Motifs using Contextual Data

Motifs are a powerful tool for analyzing physiological waveform data. Standard motif methods, however, ignore important contextual information (e.g., what the patient was doing at the time the data were collected). We hypothesize that these additional contextual data could increase the utility of motifs. Thus, we propose an extension to motifs, contextual motifs, that incorporates context. Recognizing that, oftentimes, context may be unobserved or unavailable, we focus on methods to jointly infer motifs and context. Applied to both simulated and real physiological data, our proposed approach improves upon existing motif methods in terms of the discriminative utility of the discovered motifs. In particular, we discovered contextual motifs in continuous glucose monitor (CGM) data collected from patients with type 1 diabetes. Compared to their contextless counterparts, these contextual motifs led to better predictions of hypo- and hyperglycemic events. Our results suggest that even when inferred, context is useful in both a long- and short-term prediction horizon when processing and interpreting physiological waveform data.Comment: 10 pages, 7 figures, accepted for oral presentation at KDD '1

The Use of Chemistry of Garnets and Heavy Minerals Around Lalago Kimberlite Pipe in Deciphering Diamond and Non-Diamond Bearing Kimberlite Pipes in Tanzania

More than three hundred kimberlite pipes have been reported in Tanzania. Only a few are diamond–bearing. A prospecting criteria to outline the diamond and non-diamond bearing kimberlites has been proposed. Bulk rock chemical analyses and chemistry of garnets and black minerals (picroilmenite, magnetite, rutile and titanite) collected around one kimberlite pipe in Tanzania were studied using Atomic Absorption Spectrophotometer (AAS) and Electron Microprobe (EMP). Although chromite and zircons occur in kimberlite pipes, they were not used in this study because they also characterize other surrounding rocks. Electron microprobe analysis of heavy minerals indicate that the ilmenites (picroilmenite) are poor in MgO contents (0.03 – 0.6 wt.%); but are rich in MnO (9.94 – 12.27wt.%). The garnets are poor in Cr2O3 with pronounced almandine content which has led to the conclusion of having a barren kimberlite source. It is suggested that combination of the chemistry of garnet and heavy minerals may be used as an exploration tool for deciphering diamond and non-diamond bearing kimberlites.Keywords: Electron microprobe, black minerals, mineral and fluid inclusions, kimberlites, garnets

Effect of (1,4) phenylenediamine on the corrosion of lead in 1M hydrochloric acid solution

The accelerating effect of 1,4- phenylenediamine (PDA) additions in 1M hydrochloric acid solution at temperature rang (20-60) C° has been studied by weight losses measurement during ranging time (1-260) h and by following the pb2+ concentration in solution after several times by using Atomic absorption spectroscopy (AAS) . The volume of hydrogen gas involving was followed also in presence and absence of (PDA) in the corrosive solution .Accelerating enhanced by adding (NaCl , NaBr , NaI ) was also investigated

Sintesis Senyawa Kompleks Kobalt dengan Asetilasetonato

Telah dilakukan sintesis dan karakterisasi senyawa kompleks kobalt(II) dengan ligan asetilasetonato. Karakterisasi senyawa kompleks hasil sintesis dilakukan dengan penentuan rendemen hasil sintesis, titikleleh, air kristal, kandungan logam, bobot molekul, jumlah ion, sifat magnet, serta identifikasi menggunakanspektrofotometer infra merah. Hasil penelitian menunjukkan bahwa rendemen hasil sintesis senyawa komplekskobalt-asetilasetonato yakni 82,46% dengan titik leleh sebesar 160-162◦C. Air kristal yang terkandung dalamsenyawa kompleks sebesar dua mol/mol dengan kandungan logam kobalt didalam senyawa kompleks hasilsintesis sebesar 28,32%(b/b) dan berat molekul 192 g/mol. Senyawa kompleks hasil sintesis bersifat paramagnetik dengan tidak mempunyai ion. Vibrasi karbonil dari asetilasetonato pada senyawa kompleks hasil sintesismuncul pada bilangan gelombang 1500-1600 cm−1. Struktur senyawa kompleks hasil sintesis adalah Co(acac)2H2O

Variasi Komunitas Plankton dan Parameter Oseanografi di Daerah Penangkapan Ikan Pelagis di Perairan Malang Selatan, Jawa Timur

The South Malang water is a potential area as a fishing ground. The existence of various species of small pelagic fishes such as planktivores fishes are directly influenced by the growth of phytoplankton and zooplankton. Phytoplankton has an important role as the basis of the food chain in aquatic ecosystems, whereas zooplankton is its predator. The growth of phytoplankton and zooplankton is influenced by oceanography factors. This study aims to determine the variation of the plankton community and its relationship with oceanographic parameters, as well as the spatial distribution of plankton in the fishing ground at South Malang water. The purposive sampling method with zigzag technique at 10 sampling sites was used in data collection in this research. Sedwicgk rafter counting cells were used in plankton counting methods. The plankton samples were taken horizontally and vertically at depths of 1 and 15 m with a 20 μm planktonnet, while in situ oceanographic parameters were measured using aqua quality sensor AAQ type 1183 C. The results showed that phytoplankton abundance was 49.764 cells / m3, dominated by the genus Chaetoceros (Bacillariophyceae), and zooplankton abundance of 894 ind / m3, dominated by the genus Nauplius (Copepoda). The diversity index and uniformity index of phytoplankton and zooplankton could be categorized as the middle as 1.77-1.85 and 1.70-1.77; 0.58-0.59 and 0.77-0.79, respectively, while the dominance index was included in the low category that was 0.27-0.28 and 0.24-0,27, respectively. Principal Component Analysis (PCA) analysis showed that the most important major oceanographic parameters for plankton community variation were turbidity, chlorophyll-a, dissolved oxygen and phosphate. T test results show that the spatial distribution of phytoplankton abundance and zooplankton at depth of 1 m and 15 m are significantly different. This study provides important information on the plankton abundance and oceanography factors affected at fishing ground of South Malang water

CASUAL FACTROS OF CRIMINAL BEHAVIOR IN PUNJAB, PAKISTAN

This study was conducted to find out the casual factors of criminal behavior in, Punjab Pakistan. Punjab is the largest province of Pakistan and crime ratio is also highest in this province. A questionnaire of 114 items was constructed through focus group discussion, Literature and DSM-5. Five point Likert scale was used to measure the casual factors. Data was collected from 200 criminals who conducted the crime more than one time. Data was collected from District jails of Multan and Vehari from south Punjab. Mean value was selected as 2 for mentioning a factors as cause of criminal behavior which indicate the presence of a factor. In last 20 factors were mentioned as casual factors of criminal behavior including physical abuse in schools, stubbornness in childhood, feelings of hopelessness and helplessness in childhood, strict family restrictions in childhood. Failure in intimate relations, high media exposure, short temperament, feelings of revenge and deprivation in childhood. Most of the criminals found to get their primary and secondary education in schools whereas there were lowest ratio of criminals who get religious education. There is needed to make policies to reduce these casual factors to control crime in Pakistan. Key Words: Crime, Criminal Behavior, Criminal Tendency, Criminal Factors, Causes of Crime.

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis

Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics. Currently, pharmaceutical initiatives to inhibit cyclin D1 are focused on the catalytic component since the transforming capacity is thought to reside in the cyclin D1/CDK activity. We initiated the following study to directly test the oncogenic potential of catalytically inactive cyclin D1 in an in vivo mouse model that is relevant to breast cancer. Herein, transduction of cyclin D1(-/-) mouse embryonic fibroblasts (MEFs) with the kinase dead KE mutant of cyclin D1 led to aneuploidy, abnormalities in mitotic spindle formation, autosome amplification, and chromosomal instability (CIN) by gene expression profiling. Acute transgenic expression of either cyclin D1(WT) or cyclin D1(KE) in the mammary gland was sufficient to induce a high CIN score within 7 days. Sustained expression of cyclin D1(KE) induced mammary adenocarcinoma with similar kinetics to that of the wild-type cyclin D1. ChIP-Seq studies demonstrated recruitment of cyclin D1(WT) and cyclin D1(KE) to the genes governing CIN. We conclude that the CDK-activating function of cyclin D1 is not necessary to induce either chromosomal instability or mammary tumorigenesis