MANAGEMENT OF PATIENTS WITH ACUTE KIDNEY INJURY

Presented lecture is about management of a serious condition – acute kidney injury (AKI). It is intended for students, general practitioners, family physicians, therapists and those who may face with manifestations of AKI, and on which depends its timely diagnosis and the success of therapy. Definition, epidemiology, risk factors, causes, pathogenesis, classification, symptoms, diagnosis and differential diagnosis, treatment, complications, prognosis and prevention of AKI are described

First test of an enriched 116^{116}CdWO4_4 scintillating bolometer for neutrinoless double-beta-decay searches

For the first time, a cadmium tungstate crystal scintillator enriched in $^{116}$Cd has been succesfully tested as a scintillating bolometer. The measurement was performed above ground at a temperature of 18 mK. The crystal mass was 34.5 g and the enrichment level ~82 %. Despite a substantial pile-up effect due to above-ground operation, the detector demonstrated a high energy resolution (2-7 keV FWHM in 0.2-2.6 MeV $\gamma$ energy range), a powerful particle identification capability and a high level of internal radiopurity. These results prove that cadmium tungstate is an extremely promising detector material for a next-generation neutrinoless double-beta decay bolometric experiment, like that proposed in the CUPID project (CUORE Upgrade with Particle IDentification)

ZnO-based scintillating bolometers: New prospects to study double beta decay of 64^{64}Zn

The first detailed study on the performance of a ZnO-based cryogenic scintillating bolometer as a detector to search for rare processes in zinc isotopes was performed. A 7.2 g ZnO low-temperature detector, containing more than 80\% of zinc in its mass, exhibits good energy resolution of baseline noise 1.0--2.7 keV FWHM at various working temperatures resulting in a low-energy threshold for the experiment, 2.0--6.0 keV. The light yield for $\beta$/$\gamma$ events was measured as 1.5(3) keV/MeV, while it varies for $\alpha$ particles in the range of 0.2--3.0 keV/MeV. The detector demonstrate an effective identification of the $\beta$/$\gamma$ events from $\alpha$ events using time-properties of only heat signals. %(namely, Rise time parameter). The radiopurity of the ZnO crystal was evaluated using the Inductively Coupled Plasma Mass Spectrometry, an ultra-low-background High Purity Ge $\gamma$-spectrometer, and bolometric measurements. Only limits were set at the level of $\mathcal{O}$(1--100) mBq/kg on activities of \Nuc{K}{40}, \Nuc{Cs}{137} and daughter nuclides from the U/Th natural decay chains. The total internal $\alpha$-activity was calculated to be 22(2) mBq/kg, with a major contribution caused by 6(1) mBq/kg of \Nuc{Th}{232} and 12(2) mBq/kg of \Nuc{U}{234}. Limits on double beta decay (DBD) processes in \Nuc{Zn}{64} and \Nuc{Zn}{70} isotopes were set on the level of $\mathcal{O}(10^{17}$--$10^{18})$ yr for various decay modes profiting from 271 h of acquired background data in the above-ground lab. This study shows a good potential for ZnO-based scintillating bolometers to search for DBD processes of Zn isotopes, especially in \Nuc{Zn}{64}, with the most prominent spectral features at $\sim$10--20 keV, like the two neutrino double electron capture. A 10 kg-scale experiment can reach the experimental sensitivity at the level of $\mathcal{O}(10^{24})$ yr.Comment: Prepared for submission to JINST; 27 pages, 9 figures, and 7 table

First array of enriched Zn82^{82}Se bolometers to search for double beta decay

The R&D activity performed during the last years proved the potential of ZnSe scintillating bolometers to the search for neutrino-less double beta decay, motivating the realization of the first large-mass experiment based on this technology: CUPID-0. The isotopic enrichment in $^{82}$Se, the Zn$^{82}$Se crystals growth, as well as the light detectors production have been accomplished, and the experiment is now in construction at Laboratori Nazionali del Gran Sasso (Italy). In this paper we present the results obtained testing the first three Zn$^{82}$Se crystals operated as scintillating bolometers, and we prove that their performance in terms of energy resolution, background rejection capability and intrinsic radio-purity complies with the requirements of CUPID-0

CUPID-0: the first array of enriched scintillating bolometers for 0decay investigations

The CUPID-0 detector hosted at the Laboratori Nazionali del Gran Sasso, Italy, is the first large array of enriched scintillating cryogenic detectors for the investigation of82Se neutrinoless double-beta decay (0). CUPID-0 aims at measuring a background index in the region of interest (RoI) for 0at the level of 10- 3 counts/(keV kg years), the lowest value ever measured using cryogenic detectors. CUPID-0 operates an array of Zn82Se scintillating bolometers coupled with bolometric light detectors, with a state of the art technology for background suppression and thorough protocols and procedures for the detector preparation and construction. In this paper, the different phases of the detector design and construction will be presented, from the material selection (for the absorber production) to the new and innovative detector structure. The successful construction of the detector lead to promising preliminary detector performance which is discussed here

Exploring CEvNS with NUCLEUS at the Chooz Nuclear Power Plant

Coherent elastic neutrino-nucleus scattering (CE$\nu$NS) offers a unique way to study neutrino properties and to search for new physics beyond the Standard Model. Nuclear reactors are promising sources to explore this process at low energies since they deliver large fluxes of (anti-)neutrinos with typical energies of a few MeV. In this paper, a new-generation experiment to study CE$\nu$NS is described. The NUCLEUS experiment will use cryogenic detectors which feature an unprecedentedly low energy threshold and a time response fast enough to be operated in above-ground conditions. Both sensitivity to low-energy nuclear recoils and a high event rate tolerance are stringent requirements to measure CE$\nu$NS of reactor antineutrinos. A new experimental site, denoted the Very-Near-Site (VNS) at the Chooz nuclear power plant in France is described. The VNS is located between the two 4.25 GW$_{\mathrm{th}}$ reactor cores and matches the requirements of NUCLEUS. First results of on-site measurements of neutron and muon backgrounds, the expected dominant background contributions, are given. In this paper a preliminary experimental setup with dedicated active and passive background reduction techniques is presented. Furthermore, the feasibility to operate the NUCLEUS detectors in coincidence with an active muon-veto at shallow overburden is studied. The paper concludes with a sensitivity study pointing out the promising physics potential of NUCLEUS at the Chooz nuclear power plant

Result on the neutrinoless double beta decay search of 82 Se with the CUPID-0 experiment

CUPID-0 is the first large array of scintillating Zn 82 Se cryogenic calorimeters (bolometers) implementing particle identification for the search of the neutrinoless double beta decay (0vββ). The detector consists of 24 enriched Zn 82 Se bolometers for a total 82 Se mass of 5.28 kg and it has been taking data in the underground LNGS (Italy) since March 2017. In this article we show how the dual read-out provides a powerful tool for the a particles rejection. The simultaneous use of the heat and light information allows us to reduce the background down to (3.2 +1.31.1 x10 -3 counts/(keV kg year), an unprecedented level for cryogenic calorimeters. In a total exposure of 5.46 kg year Zn 82 Se we set the most stringent limit on the 0vββ decay 82 Se half-life T 0v1/2 ≤ 4.0 x 10 24 year at 90% C.I

First search for Lorentz violation in double beta decay with scintillating calorimeters

We present the search for Lorentz violation in the double beta decay of Se-82 with CUPID-0, using an exposure of 9.95 kg x yr. We found no evidence for the searched signal and set a limit on the isotropic components of the Lorentz violating coefficient of (a) over circle ((3))(of) ((3))(of) obtained with a scintillating bolometer, showing the potentiality of this technique