Trajectory Model for Identification of Oil Spill Around the Coast of Pari Island, Seribu Islands, North Jakarta

Oil spills at sea are common in the shipping lanes of the ship as well as the locations of offshore oil drilling. Unfortunately, in every occurrence of the oil spill, we only see the effects after the occurrence, without knowing the original source. Indonesian Numerical Coastal Environmental Assessment (IndoNACE) is research collaboration between Indonesian and Germany by applying satellite data, numerical modeling, and field observations to make an assessment on environmental consequences to oil spills at sea. One of the locations of these research activities is Pari Island, Seribu Islands, North Jakarta. Simulation of hydrodynamic models around Pulau Pari with Hamburg Shelf Ocean Model (HAMSOM) was performed using tides, surface winds, and density difference of seawater as input. Afterwards, by utilizing results of the hydrodynamic model, the spreading of oil spills as well as the origin of the oil spills were estimated using forward and backward trajectory models, respectively. In the case study of Pari Island, there is a presence of thin film of oil in 5 November 2015 that disappears after one day. We suggest that the origin of oil spills were found on the beach Pari Island is expected from the east - northeast of Thousand Islands and is likely from the subsea pipeline which runs from the north to the city of Jakarta or shipping lanes through the Indonesian archipelagic sea lanes (ALKI) I of Karimata Strait up to Java Sea and the Jakarta Bay

Antibodies to the alpha(1)-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiography

BACKGROUND: Circulating agonistic autoantibodies acting at G protein-coupled receptors have been associated with numerous sever pathologies in humans. Antibodies directed predominantly against the alpha(1)-adrenergig receptor were detected in patients suffering from widespread diseases such as hypertension and type 2 diabetes. Their deleterious action has been demonstrated for peripheral organs. We postulate that antibodies to the alpha(1)-adrenergig receptor are relevant pathomolecules in diseases of the central nervous system associated with vascular impairments. METHODOLOGY/PRINCIPAL FINDINGS: Using a rat model we studied the long-term action of antibodies against the alpha(1)-adrenergig receptor either induced by immunization with a receptor peptide or applied by intravenous injection. The vasculature in the rat brains was investigated by time-of-flight magnetic resonance angiography using a 9.4 Tesla small animal MR imaging system. Visual examination of maximum-intensity-projections (MIPs) of brain angiographs revealed the development of vascular defects in antibody- exposed animals between three and eight months of treatment. Relative vascular areas were derived from representative MIP image sections by grayscale analysis and used to form an index of vascular circulation. Animals exposed to the action of alhpa(1)-adrenergig receptor antibodies showed significantly reduced vascular areas (p<0.05). Calculated index values indicated attenuated blood flow in both antibody-treated cohorts compared to their respective controls reaching with (relative units ± standard error, n = 10) 0.839±0.026 versus 0.919±0.026 statistical significance (p<0.05) for peptide-immunized rats. CONCLUSION/SIGNIFICANCE: We present evidence that antibodies to the α(1)-adrenergig receptor cause cerebrovascular impairments in the rat. Our findings suggest the pathological significance of these antibodies in pathologies of the human central nervous system linked to impairments of brain vasculature such as stroke and dementia

Thermal and ultraviolet-visible light stability kinetics of co-nanoencapsulated carotenoids.

Made available in DSpace on 2017-11-07T23:29:52Z (GMT). No. of bitstreams: 1 CantillanoArtigo02Medelin.pdf: 973610 bytes, checksum: ca860a5fd3ef76c8c4134555c1d6f7ca (MD5) Previous issue date: 2017-11-07bitstream/item/166204/1/Cantillano-Artigo-02-Medelin.pd

Normothermic mouse functional MRI of acute focal thermostimulation for probing nociception

Combining mouse genomics and functional magnetic resonance imaging (fMRI) provides a promising tool to unravel the molecular mechanisms of chronic pain. Probing murine nociception via the blood oxygenation level-dependent (BOLD) effect is still challenging due to methodological constraints. Here we report on the reproducible application of acute noxious heat stimuli to examine the feasibility and limitations of functional brain mapping for central pain processing in mice. Recent technical and procedural advances were applied for enhanced BOLD signal detection and a tight control of physiological parameters. The latter includes the development of a novel mouse cradle designed to maintain whole-body normothermia in anesthetized mice during fMRI in a way that reflects the thermal status of awake, resting mice. Applying mild noxious heat stimuli to wildtype mice resulted in highly significant BOLD patterns in anatomical brain structures forming the pain matrix, which comprise temporal signal intensity changes of up to 6% magnitude. We also observed sub-threshold correlation patterns in large areas of the brain, as well as alterations in mean arterial blood pressure (MABP) in response to the applied stimulus

Modeling to Support Groundwater Contaminant Boundaries for the Shoal Underground Nuclear Test

Groundwater flow and radionuclide transport at the Shoal underground nuclear test are characterized using three-dimensional numerical models, based on site-specific hydrologic data. The objective of this modeling is to provide the flow and transport models needed to develop a contaminant boundary defining the extent of radionuclide-contaminated groundwater at the site throughout 1,000 years at a prescribed level of confidence. This boundary will then be used to manage the Project Shoal Area for the protection of the public and the environment

Entomofauna associada à floração de milho: comparação entre sistema agroflorestal e sistema de cultivo tradicional.

Foi identificada a entomofauna associada à floração de milho (Zea mays L.) cultivado em sistema agroflorestal (SAF) e em sistema de cultivo tradicional, no município de Pelotas, RS. A observação direta dos visitantes florais foi realizada em janeiro de 2022 nos pendões de milho, durante o tempo de 5 min para cada repetição, das 6h às 19h, em delineamento de blocos ao acaso com 3 repetições para cada sistema de cultivo, ambos conduzidos em base ecológica. Durante as observações também foram registradas a temperatura do ar, umidade relativa do ar e radiação solar. Foram observados no total 501 indivíduos, todos da classe Insecta, dos quais 97,2% (487) correspondem à ordem Hymenoptera e 2,8% (14) correspondem à ordem Diptera. Os himenópteros observados estão divididos em 93,0% (466) de abelhas melíferas africanizadas, 2,8% (14) de abelhas sem ferrão e 1,4% (7) de vespas. Do total de organismos observados, 64,9% (325) foram registrados no milho sob sistema agroflorestal e 35,1% (176) no milho sob sistema tradicional, fora do SAF, o que representa um número 84,7% (149) maior de visitantes florais no milho dentro do SAF. O horário de maior visitação para o número total de individuos ocorreu das 8h às 9h. Os dados meteorológicos indicam que o SAF apresenta menor oferta de radiação solar média ao longo do dia e menor amplitude de temperatura do ar e de umidade relativa do ar do que no sistema tradicional, gerando um maior conforto térmico às abelhas, resultando na sua maior abundância nesse sistema. Portanto, para culturas dependentes de polinização cruzada por abelhas, seu cultivo sob sistema agroflorestal pode ser recomendável.ODS

Significant reduction in heart rate variability is a feature of acute decompensation of cirrhosis and predicts 90-day mortality

Background: Heart rate variability (HRV) is reduced in cirrhosis and in conditions of systemic inflammation. Whether HRV is associated with cirrhosis decompensation and development of acute‐on‐chronic liver failure (ACLF) is unknown. // Aims: To (a) validate wireless remote HRV monitoring in cirrhosis decompensation; (b) determine if severely reduced HRV is a surrogate for inflammation and progression of cirrhosis decompensation; (c) assess if measuring HRV determines prognosis in cirrhosis decompensation. // Methods: One hundred and eleven patients at risk of cirrhosis decompensation at two clinical sites were monitored for HRV. Standard deviation of all normal beat‐beat intervals (SDNN) reflecting HRV was assessed using remote monitoring (Isansys Lifetouch) and/or Holter ECG recording. Clinical outcomes and major prognostic scores were recorded during 90‐day follow‐up. // Results: Reduced HRV denoted by lower baseline SDNN, correlated with severity of decompensation (median 14 (IQR 11‐23) vs 33 (25‐42); P < 0.001, decompensated patients vs stable outpatient cirrhosis). Furthermore, SDNN was significantly lower in patients developing ACLF compared to those with only decompensation (median 10 (IQR9‐12) vs 16 (11‐24); P = 0.02), and correlated inversely with MELD and Child‐Pugh scores, and C‐reactive protein (all P < 0.0001) and white cell count (P < 0.001). SDNN predicted disease progression on repeat measures and appeared an independent predictor of 90‐day mortality (12 patients). An SDNN cut‐off of 13.25 ms had a 98% negative predictive value. // Conclusions: This study demonstrates that remote wireless HRV monitoring identifies cirrhosis patients at high risk of developing ACLF and death, and suggests such monitoring might guide the need for early intervention in such patients. Clinical Trial number: NIHR clinical research network CPMS ID 4949

Sistema sulco/camalhão para irrigação e drenagem em áreas de várzea.

SISTEMA SULCO/CAMALHÃO PARA IRRIGAÇÃO E DRENAGEM EM ÁREAS DE VÁRZEA - A soja e o milho são as principais culturas produtoras de grãos utilizadas na diversificação do sistema de produção nas várzeas do Rio Grande do Sul, em rotação com o arroz irrigado. Os principais fatores limitantes, para que estas culturas sejam produtivas e rentáveis neste sistema, são a deficiente drenagem natural do solo e a ocorrência de freqüentes períodos de estiagem, acarretando alternância entre o excesso e o déficit de umidade no solo. A Embrapa Clima Temperado testou e validou a técnica sulco/camalhão em áreas sistematizadas com e sem declive, para estes cultivos, com resultados bastante promissores. O sistema consiste na estruturação da lavoura para a irrigação por sulcos, obtendo-se, ao mesmo tempo, grande benefício em drenagem, com o cultivo sobre os camalhões formados entre os sulcos. Esta técnica, como sistema complementar de drenagem superficial do solo, mostrou-se muito eficiente mesmo nos cultivos em áreas sistematizadas sem declive, onde não existe um gradiente para escoamento superficial da água. O principal requisito para a irrigação por sulcos é que o terreno tenha uma declividade constante e uniforme, requerendo geralmente a sistematização do terreno. Para irrigações mais uniformes e eficientes, a declividade deve variar de 0,10% a 0,50%, sendo que valores intermediários entre 0,15% e 0,30% são os mais indicadosbitstream/item/31294/1/comunicado-165.pd