1,817 research outputs found
Longâterm effects of crizotinib in ALKâpositive tumors (excluding NSCLC): A phase 1b openâlabel study
Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation.
Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions. Endoplasmic reticulum (ER) stress elicits EC dysregulation in metabolic syndrome. We hypothesized that ER plays a central role in mechanosensing of atherosusceptible shear stress (SS) by signaling enhanced inflammation. Aortic EC were stimulated with low-dose TNFα (0.3 ng/ml) in a microfluidic channel that produced a linear SS gradient over a 20mm field ranging from 0-16 dynes/cm2. High-resolution imaging of immunofluorescence along the monolayer provided a continuous spatial metric of EC orientation, markers of ER stress, VCAM-1 and ICAM-1 expression, and monocyte recruitment. VCAM-1 peaked at 2 dynes/cm2 and decreased to below static TNFα-stimulated levels at atheroprotective-SS of 12 dynes/cm2, whereas ICAM-1 rose to a maximum in parallel with SS. ER expansion and activation of the unfolded protein response also peaked at 2 dynes/cm2, where IRF-1-regulated VCAM-1 expression and monocyte recruitment also rose to a maximum. Silencing of PECAM-1 or key ER stress genes abrogated SS regulation of VCAM-1 transcription and monocyte recruitment. We report a novel role for ER stress in mechanoregulation at arterial regions of atherosusceptible-SS inflamed by low-dose TNFα
A dual output polarimeter devoted to the study of the Cosmic Microwave Background
We have developed a correlation radiometer at 33 GHz devoted to the search
for residual polarization of the Cosmic Microwave Background (CMB). The two
instruments`s outputs are linear combination of two Stokes Parameters (Q and U
or U and V). The instrument is therefore directly sensitive to the polarized
component of the radiation (respectively linear and circular). The radiometer
has a beam-width oif 7 or 14 deg, but it can be coupled to a telescope
increasing the resolution. The expected CMB polarization is at most a part per
milion. The polarimeter has been designed to be sensitive to this faint signal,
and it has been optimized to improve its long term stability, observing from
the ground. In this contribution the performances of the instrument are
presented, together with the preliminary test and observations.Comment: 12 pages, 6 figures, in print on the Proc. SPIE Conf. - August 200
Stepping away from serendipity in Deep Eutectic Solvent formation: Prediction from precursors ratio
The Emergence of Aqueous Ammonium-Ion Batteries
Aqueous ammonium-ion (NH4+) batteries (AAIB) are a recently emerging technology that utilize the abundant electrode resources and the fast diffusion kinetics of NH to deliver an excellent rate performance at a low cost. Although significant progress has been made on AAIBs, the technology is still limited by various challenges. In this Minireview, the most recent advances are comprehensively summarized and discussed, including cathode and anode materials as well as the electrolytes. Finally, a perspective on possible solutions for the current limitations of AAIBs is provided
Effect of Aging-Induced Dioxolane Polymerization on the Electrochemistry of Carbon-Coated Lithium Sulfide
A note on the integral equation for the Wilson loop in N = 2 D=4 superconformal Yang-Mills theory
We propose an alternative method to study the saddle point equation in the
strong coupling limit for the Wilson loop in D=4 super
Yang-Mills with an SU(N) gauge group and 2N hypermultiplets. This method is
based on an approximation of the integral equation kernel which allows to solve
the simplified problem exactly. To determine the accuracy of this
approximation, we compare our results to those obtained recently by Passerini
and Zarembo. Although less precise, this simpler approach provides an explicit
expression for the density of eigenvalues that is used to derive the planar
free energy.Comment: 12 pages, v2: section 2.5 (Free Energy) amended and reference added,
to appear in J. Phys.
A perspective on the role of anions in highly concentrated aqueous electrolytes
Highly concentrated aqueous electrolytes enable a wider electrochemical stability window and, thus, higher energy batteries compared to conventional dilute aqueous solutions. Multiple properties of the electrolyte, e.g., ionic interactions, solvation structure, ion transport, tendency to hydrolyze, and capability to form a solid electrolyte interphase, distinctly change when the salt concentration is increased and highly depend on the salt anion. This work aims at reviewing, discussing and rationalizing the role of the salt anion in these physical and chemical properties in order to provide perspective guidelines for future developments
Developments in anaplastic large-cell lymphoma: targeting the anaplastic lymphoma kinase
Francesca Farina, Alessandra Stasia, Carlo Gambacorti-Passerini Department of Health Sciences, University of Milano Bicocca, Monza, Italy Abstract: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase protein implicated in a variety of hematological malignancies and solid tumors. ALK contributes to the development of cancers in different cell lineages through a variety of genetic mechanisms: gene fusions, activating point mutations, and possibly gene amplification. Recent developments led to significant therapeutic advances, including efficient diagnostic tests and ALK-targeting agents. This review addresses some therapeutic considerations with regard to the use of ALK inhibitors in ALK-positive lymphomas where, in spite of the advanced stage of the disease, long-lasting responses could be obtained in a substantial portion of heavily pretreated patients. Data and mechanisms for the development of resistance to ALK inhibitors will also be presented and discussed. Keywords: ALK, lymphoma, tyrosine kinase, targeted therapy, crizotini
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