7,770 research outputs found
A mechanism for NADPH inhibition of catalase compound II formation
AbstractCatalase-bound NADPH both prevents and reverses the accumulation of inactive bovine liver catalase peroxide compound II generated by āendogenousā donors under conditions of steady H2O2 formation without reacting rapidly with either compound I or compound II. It thus differs both from classical 2-electron donors of the ethanol type, and from 1-electron donors of the ferrocyanide/phenol type. NADPH also inhibits compound II formation induced by the exogenous one-electron donor ferrocyanide. A catalase reaction scheme is proposed in which the initial formation of compound II from compound I involves production of a neighbouring radical species. NADPH blocks the final formation of stable compound II by reacting as a 2-electron donor to compound II and to this free radical. The proposed behaviour resembles that of labile free radicals formed in cytochrome c peroxidase and myoglobin. Such radical migration patterns within haem enzymes are increasingly common motifs
Two phase detonation studies
An experimental study of the passage of a shock wave over a burning fuel drop is described. This includes high speed framing photographs of the interaction taken at 500,000 frames per second. A theoretical prediction of the ignition of a fuel drop by a shock wave is presented and the results compared with earlier experimental work. Experimental attempts to generate a detonation in a liquid fuel drop (kerosene)-liquid oxidizer drop (hydrogen peroxide)-inert gas-environment are described. An appendix is included which gives the analytical prediction of power requirements for the drop generator to produce certain size drops at a certain mass rate. A bibliography is also included which lists all of the publications resulting from this research grant
Ejaculate allocation by male sand martins, Riparia riparia
Males of many species allocate sperm to ejaculates strategically in response to variation in the risk and intensity of sperm competition. The notable exception is passerine birds, in which evidence for strategic allocation is absent. Here we report the results of a study testing for strategic ejaculate allocation in a passerine bird, the sand martin (Riparia riparia). Natural ejaculates were collected from males copulating with a model female. Ejaculates transferred in the presence of a rival male contained significantly more sperm than ejaculates transferred in the absence of a rival male. There was no evidence that this difference was due to the confounding effects of the year of ejaculate collection, the identity of the model female, the colony, the stage of season or the period of the day in which ejaculates were collected. A more detailed examination of the ejaculate patterns of individual males, achieved by the DNA profiling of ejaculates, provided additional evidence for strategic allocation of sperm
Machine learning -- based diffractive imaging with subwavelength resolution
Far-field characterization of small objects is severely constrained by the
diffraction limit. Existing tools achieving sub-diffraction resolution often
utilize point-by-point image reconstruction via scanning or labelling. Here, we
present a new imaging technique capable of fast and accurate characterization
of two-dimensional structures with at least wavelength/25 resolution, based on
a single far-field intensity measurement. Experimentally, we realized this
technique resolving the smallest-available to us 180-nm-scale features with
532-nm laser light. A comprehensive analysis of machine learning algorithms was
performed to gain insight into the learning process and to understand the flow
of subwavelength information through the system. Image parameterization,
suitable for diffractive configurations and highly tolerant to random noise was
developed. The proposed technique can be applied to new characterization tools
with high spatial resolution, fast data acquisition, and artificial
intelligence, such as high-speed nanoscale metrology and quality control, and
can be further developed to high-resolution spectroscop
Effect of prophylactic corticosteroids on the incidence of reactions in newly diagnosed multibacillary leprosy patients [5]
To the editor: Leprosy reactions, including reversal re-actions and episodes of neuritis, are known to occur in leprosy patients most frequently in the first few months after starting multidrug therapy (MDT), especially in cases with multibacillary (MB) disease. Such reactions can lead to impairment of nerve function, and subsequent deformity and disability. That this can occur in leprosy patients who present without any nerve function impairment (NFI) at diagnosis is a discouraging phenomenon for both the patient and the doctor or health worker.It is an axiom of modern leprosy controlthat early case detection and treatment with MDT can prevent much NFI by halting the multiplication of the leprosy bacillus, and that this is the single most important activity in the prevention of NFI. [...]<br/
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