Genes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis

In this study, we analyzed association of genes of vascular homeostasis with hypertension and renal survival of CGN patients. The study sample included 238 patients with CGN and 304 healthy subjects of population control. Ten polymorphisms of ten genes of vascular homeostasis were genotyped through polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) analysis and TaqMan assays. Association of the genotypes with renal survival was analyzed by the Kaplan-Meier estimato

Epidemiology and significance of malnutrition among outpatients with heart failure

To assess the prevalence and identify markers of malnutrition in outpatients with chronic heart failure (CHF

Clinical-functional changes of myocardium after percutaneous coronary interventions in patients with chronic heart failure

The study aimed to evaluate the results of clinical and functional changes in the left ventricular myocardium in patients with CHF after transluminal balloon angioplasty (TLBAP) of the coronary arteries with stenting of the coronary arteries during the observed period and to study the safety of surgical intervention in these patients. The study showed a statistically significant decrease in the functional class of CHF after percutaneous coronary intervention, followed by an improvement in the diastolic function (E/A) of the LV in the course of the observed perio

Association study of genetic polymorphisms of vasoactive hormones with the risk of preeclampsia

The present study was designed to investigate an association of genetic polymorphisms of vasoactive hormones with the risk of preeclampsi

Agranulocytosis in Felty’s syndrome: a case from clinical practice

Differential diagnosis of articular syndrome is one of the leading issues of primary medical sanitary care. Timely and correct diagnosis of rheumatic diseases made by an internist in an out-patient setting is a cornerstone of successful treatment and prevention of possible complications. The masks of clinical course, subtle symptoms, as well as pathomorphosis of the disease make the accurate diagnosis difficult to establish. Among rheumatic diseases more and more often isolated hematological manifestations are observed on the onset of the disease. Among them the leading place is taken by Felty’s syndrome. Being a form of seropositive rheumatoid arthritis, it is often associated with cytopenia. The aim of the article is to draw attention to the problem of timely diagnosis of Felty’s syndrome. The presented clinical case of Felty’s syndrome with agranulocytosis was based on clinical, laboratory, instrumental data obtained on examination of a patient. The features of the course, diagnostic methods and treatment methods of the pathology are discussed. The treatment efficacy of corticosteroids and cytostatics, similarities in clinical presentation and course of the syndrome with lymphoproliferative diseases and liver cirrhosis are presented. According to the obtained data a conclusion was made about the need for early diagnosis and complex examination in case of Felty’s syndrome for successful treatment of the nosology

Estimate or the effectiveness of intelligent information system of early diagnosis and prognosis of cardiovascular disease

This article describes a new approach to the implementation of the training program of risk probability of coronary heart disease (CHD) remote evaluation. It describes an example of training sample formation based on the statistical analysis of medical data. The proposed solution will allow medical personnel to carry out the personification of cardiac services and first of all, preventive orientation. Also a method for assessing the effectiveness of the program of expert system "ARM-Cardiologist" on the results of ongoing clinical trials is providedyesБелгородский государственный университе

The role of chemokine genes in the formation of terminal stage of chronic renal failure

The data on the role of chemokine genes (+1931A/T CCL4, A/G CXCL11 (rs4512021), -403A/G CCL5, C/G CCL2 (rs2857657), -801G/A CXCL12) in the formation of terminal stage of chronic renal failure, in patients with chronic glomerulonephritis, is presented in the work. It was established, that the allele A CXCL11 (rs4512021) (OR = 1.65) was the marker for the development of terminal stage of chronic renal insufficiency, and the genotype GG CXCL11was a protective factor for the development of terminal stage of chronic renal failure (OR = 0.22

Associations of cytokines genetic polymorphisms with hypertension progress

The article presents results of comparative analysis of cytokines genes polymorphous variants occurrence among hypertension patients with burdened familial history regarding this disease and in a control grou

Features of endothelial dysfunction in renal hypertension

Endothelial dysfunction is a marker of vascular disease, as well as the development and progression of hypertension in chronic kidney disease. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3574

The effectiveness of glucocorticoid therapy in patients with chronic glomerulonephritis, depending on the polymorphic markers of cytokine genes

The paper presents the results of a study of interrelationships of polymorphic cytokine loci (rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1 and rs1800469 TGFβ-1) with the features of glucocorticoid therapy in patients with chronic glomerulonephriti