The present study was designed to investigate an association of genetic polymorphisms of vasoactive hormones with the risk of preeclampsi

Churnosov, M.

Efremova, O.

Elykova, A.

Polonikov, A.

Sorokina, I.

English

DSpace at Belgorod State University

6th Singapore Health & Biomedical Congress 2015PP-BSTR-11Association Study of Genetic Polymorphisms of Vasoactive Hormones with the Risk of PreeclampsiaA POLONIKOV1, A ELYKOVA2, I SOROKINA2, O EFREMOVA2, M CHURNOSOV2[Kursk State Medical University, Russia, 2Belgorod State University, RussiaBackground & Hypothesis:Vasoactive hormones play an important role in the pathogenesis of preeclampsia. Investigations focused on the molecular genetic mechanisms of preeclampsia are limited. The present study was designed to investigate an association of genetic polymorphisms of vasoactive hormones with the risk of preeclampsia.Methods:A total of 459 women comprising 250 patients with a diagnosis of preeclampsia (18-44 years old) and 209 healthy controls (18-42 years old) were recruited for the study. The following genetic polymorphisms of vasoactive hormones were investigated: +46G/A ADRB2, 4a/4b eNOS, K198NET- 1. Genotyping of the gene polymorphisms were done using a real-time polymerase chain reaction with TaqMan probes. Statistical analysis was performed with STATISTICA for Windows 8.0.Results:It was found that the combinations of the 2 genetic variants such as -4b eNOS and 198N ET-1, and also 198N ET-1 and + 46A ADRB2 were 1.4-1.6 higher among pregnant women without preeclampsia (35.89% and 23.65%, respectively) than among women with preeclampsia (25.6%, Pcor = 0.04, 14.46%, Pcor = 0.032, respectively).Discussion & Conclusion:The study suggests that combinations of 198N ET-1, 46A ADRB2, 4b eNOS variants exert protective effects against the risk of preeclampsia. The study was supported by the project (“Studying of the genetic risk factors for multifactorial diseases”).S323 Annals Academy of Medicine October 2015, Vol. 44 (Suppl) No. 10

Association study of genetic polymorphisms of vasoactive hormones with the risk of preeclampsia

http://dspace.bsu.edu.ru/bitstream/123456789/28291/1/Elykova_Association.pdf

Association study of genetic polymorphisms of vasoactive hormones with the risk of preeclampsia

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