Bootstrapping a Portuguese WordNet from Galician, Spanish and English wordnets

Series: Lecture notes in computer science, ISSN 0302-9743, vol. 8854In this article we exploit the possibility on bootstrapping an European Portuguese WordNet from the English, Spanish and Galician wordnets using Probabilistic Translation Dictionaries automatically created from parallel corpora. The process generated a total of 56~770 synsets and 97~058 variants. An evaluation of the results using the Brazilian OpenWordNet-PT as a gold standard resulted on a precision varying from 53\% to 75\% percent, depending on the cut-line. The results were satisfying and comparable to similar experiments using the WN-Toolkit.PEst-OE/EEI/UI0752/2014, TIN2012-38584-C06-01, TIN2012-38584-C06-0

SenSem: sentidos verbales, semántica oracional y anotación de corpus

En este artículo presentamos el desarrollo del proyecto SenSem (BFF2003-06456), que tiene como objetivo describir y representar el comportamiento léxico, sintáctico y semántico de los verbos del español. En el desarrollo de este proyecto se están construyendo dos recursos: un corpus de oraciones asociadas a su interpretación sintáctico-semántica y un léxico donde cada sentido verbal se asocia a un conjunto de ejemplos anotados del corpus

SenSem: sentidos verbales, semántica oracional y anotación de corpus

En este artículo presentamos el desarrollo del proyecto SenSem (BFF2003-06456), que tiene como objetivo describir y representar el comportamiento léxico, sintáctico y semántico de los verbos del español. En el desarrollo de este proyecto se están construyendo dos recursos: un corpus de oraciones asociadas a su interpretación sintáctico-semántica y un léxico donde cada sentido verbal se asocia a un conjunto de ejemplos anotados del corpus

New synthetic AICAR derivatives with enhanced AMPK and ACC activation

5-Aminoimidazole-4-carboxamide riboside (AICAR) has an important role in the regulation of the cellular metabolism showing a broad spectrum of therapeutic activities against different metabolic processes. Due to these proven AICAR properties, we have designed, synthesized and tested the biological activity of two ribose-modified AICAR derivatives, named A3 and A4, in comparison to native AICAR and its 5'-phosphorylated counterpart ZMP. Our findings have shown that A3 and A4 derivatives induce the phosphorylation of 5'-AMP activated protein kinase α (AMPKα), which leads to the inhibition of acetyl-CoA carboxylase (ACC), and down-regulate the activity of the extracellular signal-regulated kinases (ERK1/2). Cytotoxicity tests demonstrated that A3 and A4 do not significantly reduce cell viability up to 24 h. Taken together our results indicate that A3 and A4 have a comparable activity to AICAR and ZMP at 0.5 and 1 mM suggesting their potential use in future pharmacological strategies relating to metabolic diseases