Nuovo ruolo degli inibitori dell’aromatasi: Impiego in terapia adiuvante

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A Multi-Membership Catalogue for 1876 Open Clusters using UCAC4 data

The main objective of this work is to determine the cluster members of 1876 open clusters, using positions and proper motions of the astrometric catalogue UCAC4. For this purpose we apply three different methods, all them based on a Bayesian approach, but with different formulations: a purely parametric method, another completely non-parametric algorithm, and a third, recently developed by Sampedro & Alfaro, using both formulations at different steps of the whole process. The first and second statistical moments of the members phase-space subspace, obtained after applying the three methods, are compared for every cluster. Although, on average, the three methods yield similar results, specific differences between them, as well as for some particular clusters, are also present. The comparison with other published catalogues shows good agreement. We have also estimated for the first time the mean proper motion for a sample of 18 clusters. The results are organized in a single catalogue formed by two main files, one with the most relevant information for each cluster, partially including that in UCAC4, and the other showing the individual membership probabilities for each star in the cluster area. The final catalogue, with an interface design that enables an easy interaction with the user, is available in electronic format at SSG-IAA (http://ssg.iaa.es/en/content/sampedro-cluster-catalog) website.Comment: Accepted for publication in MNRAS. 9 pages, 3 figures, 6 table

Should helicopter noise be measured differently from other aircraft noise? A review of the psychoacoustic literature

A review of 34 studies indicates that several factors or variables might be important in providing a psychoacoustic foundation for measurements of the noise from helicopters. These factors are phase relations, tail rotor noise, repetition rate, crest level, and generic differences between conventional aircraft and helicopters. Particular attention was given to the impulsive noise known as blade slap. Analysis of the evidence for and against each factor reveals that, for the present state of scientific knowledge, none of these factors should be regarded as the basis for a significant noise measurement correction due to impulsive blade slap. The current method of measuring effective perceived noise level for conventional aircraft appears to be adequate for measuring helicopter noise as well

Design methodology for a community response questionnaire on sonic boom exposure

A preliminary draft questionnaire concerning community response to sonic booms was developed. Interviews were conducted in two communities that had experienced supersonic overflights of the SR-71 airplane for several years. Even though the overflights had ceased about 6 months prior to the interviews, people clearly remembered hearing sonic booms. A total of 22 people living in central Utah and 23 people living along Idaho/Washington state border took part in these interviews. The draft questionnaire was constantly modified during the study in order to evaluate different versions. Questions were developed which related to annoyance, startle, sleep disturbance, building vibration, and building damage. Based on the data collected, a proposed community response survey response instrument was developed for application in a full-scale sonic boom study

CLASH: accurate photometric redshifts with 14 HST bands in massive galaxy cluster cores

We present accurate photometric redshifts for galaxies observed by the Cluster Lensing And Supernova survey with Hubble (CLASH). CLASH observed 25 massive galaxy cluster cores with the Hubble Space Telescope in 16 filters spanning 0.2–1.7 μm. Photometry in such crowded fields is challenging. Compared to our previously released catalogues, we make several improvements to the photometry, including smaller apertures, intracluster light subtraction, point spread function matching and empirically measured uncertainties. We further improve the Bayesian photometric redshift estimates by adding a redder elliptical template and by inflating the photometric uncertainties of the brightest galaxies. The resulting photometric redshift accuracies are dz/(1+z) ∼ 0.8, 1.0 and 2.0 per cent for galaxies with I-band F814W AB magnitudes < 18, 20 and 23, respectively. These results are consistent with our expectations. They improve on our previously reported accuracies by a factor of 4 at the bright end and a factor of 2 at the faint end. Our new catalogue includes 1257 spectroscopic redshifts, including 382 confirmed cluster members. We also provide stellar mass estimates. Finally, we include lensing magnification estimates of background galaxies based on our public lens models. Our new catalogue of all 25 CLASH clusters is available via Mikulski Archive for Space Telescopes. The analysis techniques developed here will be useful in other surveys of crowded fields, including the Frontier Fields and surveys carried out with Javalambre-Physics of the Accelerated Universe Astrophysical Survey and James Webb Space Telescope

Summarizing First-Person Videos from Third Persons' Points of Views

Video highlight or summarization is among interesting topics in computer vision, which benefits a variety of applications like viewing, searching, or storage. However, most existing studies rely on training data of third-person videos, which cannot easily generalize to highlight the first-person ones. With the goal of deriving an effective model to summarize first-person videos, we propose a novel deep neural network architecture for describing and discriminating vital spatiotemporal information across videos with different points of view. Our proposed model is realized in a semi-supervised setting, in which fully annotated third-person videos, unlabeled first-person videos, and a small number of annotated first-person ones are presented during training. In our experiments, qualitative and quantitative evaluations on both benchmarks and our collected first-person video datasets are presented.Comment: 16+10 pages, ECCV 201

Thrombin Receptors on Human Platelets INITIAL LOCALIZATION AND SUBSEQUENT REDISTRIBUTION DURING PLATELET ACTIVATION

Platelet responses to thrombin are at least partly mediated by a G-protein-coupled receptor whose NH2 terminus is a substrate for thrombin. In the present studies we have examined the location of thrombin receptors in resting platelets and followed their redistribution during platelet activation. The results reveal several new aspects of thrombin receptor biology. 1) On resting platelets, approximately two-thirds of the receptors were located in the plasma membrane. The remainder were present in the membranes of the surface connecting system. 2) When platelets were activated by ADP or a thromboxane analog, thrombin receptors that were initially in the surface connecting system were exposed on the platelet surface, increasing the number of detectable receptors by 40% and presumably making them available for subsequent activation by thrombin. 3) Platelet activation by thrombin rapidly abolished the binding of the antibodies whose epitopes are sensitive to receptor cleavage and left the platelets in a state refractory to both thrombin and the agonist peptide, SFLLRN. This was accompanied by a 60% decrease in the binding of receptor antibodies directed COOH-terminal to the cleavage site irrespective of whether the receptors were activated proteolytically by thrombin or nonproteolytically by SFLLRN. 4) The loss of antibody binding sites caused by thrombin was due in part to receptor internalization and in part to the shedding of thrombin receptors into membrane microparticles, especially under conditions in which aggregation was allowed to occur. However, at least 40% of the cleaved receptors remained on the platelet surface. 5) Lacking the ability to synthesize new receptors and lacking an intracellular reserve of preformed receptors comparable to that found in endothelial cells, platelets were unable to repopulate their surface with intact receptors following exposure to thrombin. This difference underlies the ability of endothelial cells to recover responsiveness to thrombin rapidly while platelets do not, despite the presence on both of the same receptor for thrombin