1,233 research outputs found
Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents
During dynamic exercise, mechanisms controlling the cardiovascular apparatus operate to provide adequate oxygen to fulfill metabolic demand of exercising muscles and to guarantee metabolic end-products washout. Moreover, arterial blood pressure is regulated to maintain adequate perfusion of the vital organs without excessive pressure variations. The autonomic nervous system adjustments are characterized by a parasympathetic withdrawal and a sympathetic activation. In this review, we briefly summarize neural reflexes operating during dynamic exercise. The main focus of the present review will be on the central command, the arterial baroreflex and chemoreflex, and the exercise pressure reflex. The regulation and integration of these reflexes operating during dynamic exercise and their possible role in the pathophysiology of some cardiovascular diseases are also discusse
Constraints on the environment and energetics of the Broad-Line Ic SN2014ad from deep radio and X-ray observations
Broad-line type Ic Supernovae (BL-Ic SNe) are characterized by high ejecta
velocity ( km s) and are sometimes associated with the
relativistic jets typical of long duration ( s) Gamma-Ray Bursts
(L-GRBs). The reason why a small fraction of BL-Ic SNe harbor relativistic jets
is not known. Here we present deep X-ray and radio observations of the BL-Ic
SN2014ad extending from to days post explosion. SN2014ad was not
detected at either frequency and has no observational evidence of a GRB
counterpart. The proximity of SN2014ad ( Mpc) enables very deep
constraints on the progenitor mass-loss rate and on the total energy
of the fast ejecta . We consider two synchrotron emission scenarios for a
wind-like circumstellar medium (CSM): (i) uncollimated non-relativistic ejecta,
and (ii) off-axis relativistic jet. Within the first scenario our observations
are consistent with GRB-less BL-Ic SNe characterized by a modest energy budget
of their fast ejecta ( erg), like SNe 2002ap and 2010ay.
For jetted explosions, we cannot rule out a GRB with erg
(beam-corrected) with a narrow opening angle ()
observed moderately off-axis () and
expanding in a very low CSM density ( M
yr). Our study shows that off-axis low-energy jets expanding in a
low-density medium cannot be ruled out even in the most nearby BL-Ic SNe with
extensive deep observations, and might be a common feature of BL-Ic SNe.Comment: 9 pages, 5 figures, accepted in Ap
Taming Data Caches for Predictable Execution on GPU-based SoCs
Heterogeneous SoCs (HeSoCs) typically share a single DRAM between the CPU and GPU, making workloads susceptible to memory interference, and predictable execution troublesome. State-of-the art predictable execution models (PREM) for HeSoCs prefetch data to the GPU scratchpad memory (SPM), for computations to be insensitive to CPU-generated DRAM traffic. However, the amount of work that the small SPM sizes allow is typically insufficient to absorb CPU/GPU synchronization costs. On-chip caches are larger, and would solve this issue, but have been argued too unpredictable due to self-evictions. We show how self-eviction can be minimized in GPU caches via clever managing of prefetches, thus lowering the performance cost, while retaining timing predictability
The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement
Diaphyseal fractures represent a complex biological entity that could often end into impaired bone-healing, with delayed union and non-union occurring up to 10% of cases. The role of the modern orthopaedic surgeon is to optimize the fracture healing environment, recognize and eliminate possible interfering factors, and choose the best suited surgical fixation technique. The impaired reparative process after surgical intervention can be modulated with different surgical techniques, such as dynamization or exchange nailing after failed intramedullary nailing. Moreover, the mechanical stability of a nail can be improved through augmentation plating, bone grafting or external fixation techniques with satisfactory results. According to the “diamond concept”, local therapies, such as osteoconductive scaffolds, bone growth factors, and osteogenic cells can be successfully applied in “polytherapy” for the enhancement of delayed union and non-union of long bones diaphyseal fractures. Moreover, systemic anti-osteoporosis anabolic drugs, such as teriparatide, have been proposed as off-label treatment for bone healing enhancement both in fresh complex shaft fractures and impaired unions, especially for fragility fractures. The article aims to review the biological and mechanical principles of failed reparative osteogenesis of diaphyseal fractures after surgical treatment. Moreover, the evidence about the modern non-surgical and pharmacological options for bone healing enhancement will discussed
Thermal simulations for optical transition radiation screen for Eli-NP compton gamma source
The ELI-NP GBS (Extreme Light Infrastructure-Nuclear Physics Gamma Beam Source) is a high brightness elec-tron LINAC that is being built in Romania. The goal for this facility is to provide high luminosity gamma beam through Compton Backscattering. A train of 32 bunches at 100Hz with a nominal charge of 250pC is accelerated up to 740 MeV. Two interaction points with an IR Laser beam produces the gamma beam at different energies. In order to measure the electron beam spot size and the beam proper-ties along the train, the OTR screens must sustain the ther-mal and mechanical stress due to the energy deposited by the bunches. This paper is an ANSYS study of the issues due to the high quantity of energy transferred to the OTR screen. They will be shown different analysis, steady-state and thermal transient analysis, where the input loads will be the internal heat generation equivalent to the average power, deposited by the ELI-GBS beam in 512 ns, that is the train duration. Each analyses will be followed by the structural analysis to investigate the performance of the OTR materi
Infectious agents including COVID-19 and the involvement of blood coagulation and fibrinolysis. A narrative review
Platelets, blood coagulation along with fibrinolysis are greatly involved in the pathophysiology of infectious diseases induced by bacteria, parasites and virus. This phenomenon is not surprising since both the innate immunity and the hemostatic systems are two ancestral mechanisms which closely cooperate favoring host's defense against foreign invaders. However, the excessive response of these systems may be dangerous for the host itself
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