1,056 research outputs found
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Lessons Learned and Next Steps in Energy Efficiency Measurement and Attribution: Energy Savings, Net to Gross, Non-Energy Benefits, and Persistence of Energy Efficiency Behavior
This white paper examines four topics addressing evaluation, measurement, and attribution of direct and indirect effects to energy efficiency and behavioral programs: Estimates of program savings (gross); Net savings derivation through free ridership / net to gross analyses; Indirect non-energy benefits / impacts (e.g., comfort, convenience, emissions, jobs); and, Persistence of savings
Progression from ocular hypertension to visual field loss in the English hospital eye service
Background There are more than one million National Health Service visits in England and Wales each year for patients with glaucoma or ocular hypertension (OHT). With the ageing population and an increase in optometric testing, the economic burden of glaucoma-related visits is predicted to increase. We examined the conversion rates of OHT to primary open-angle glaucoma (POAG) in England and assessed factors associated with risk of conversion.
Methods Electronic medical records of 45 309 patients from five regionally different glaucoma clinics in England were retrospectively examined. Conversion to POAG from OHT was defined by deterioration in visual field (two consecutive tests classified as stage 1 or worse as per the glaucoma staging system 2). Cox proportional hazards models were used to examine factors (age, sex, treatment status and baseline intraocular pressure (IOP)) associated with conversion.
Results The cumulative risk of conversion to POAG was 17.5% (95% CI 15.4% to 19.6%) at 5 years. Older age (HR 1.35 per decade, 95% CI 1.22 to 1.50, p<0.001) was associated with a higher risk of conversion. IOP-lowering therapy (HR 0.45, 95% CI 0.35 to 0.57, p<0.001) was associated with a lower risk of conversion. Predicted 5-year conversion rates for treated and untreated groups were 14.0% and 26.9%, respectively.
Conclusion Less than one-fifth of OHT patients managed in glaucoma clinics in the UK converted to POAG over a 5-year period, suggesting many patients may require less intensive follow-up. Our study provides real-world evidence for the efficacy of current management (including IOP-lowering treatment) at reducing risk of conversion
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Time to abandon over-simplified surrogates of ocular perfusion pressure in glaucoma research
Integrin α2β1 Expression Regulates Matrix Metalloproteinase-1-Dependent Bronchial Epithelial Repair in Pulmonary Tuberculosis.
Pulmonary tuberculosis (TB) is caused by inhalation of Mycobacterium tuberculosis, which damages the bronchial epithelial barrier to establish local infection. Matrix metalloproteinase-1 plays a crucial role in the immunopathology of TB, causing breakdown of type I collagen and cavitation, but this collagenase is also potentially involved in bronchial epithelial repair. We hypothesized that the extracellular matrix (ECM) modulates M. tuberculosis-driven matrix metalloproteinase-1 expression by human bronchial epithelial cells (HBECs), regulating respiratory epithelial cell migration and repair. Medium from monocytes stimulated with M. tuberculosis induced collagenase activity in bronchial epithelial cells, which was reduced by ~87% when cells were cultured on a type I collagen matrix. Matrix metalloproteinase-1 had a focal localization, which is consistent with cell migration, and overall secretion decreased by 32% on type I collagen. There were no associated changes in the specific tissue inhibitors of metalloproteinases. Decreased matrix metalloproteinase-1 secretion was due to ligand-binding to the α2β1 integrin and was dependent on the actin cytoskeleton. In lung biopsies, samples from patients with pulmonary TB, integrin α2β1 is highly expressed on the bronchial epithelium. Areas of lung with disrupted collagen matrix showed an increase in matrix metalloproteinases-1 expression compared with areas where collagen was comparable to control lung. Type I collagen matrix increased respiratory epithelial cell migration in a wound-healing assay, and this too was matrix metalloproteinase-dependent, since it was blocked by the matrix metalloproteinase inhibitor GM6001. In summary, we report a novel mechanism by which α2β1-mediated signals from the ECM modulate matrix metalloproteinase-1 secretion by HBECs, regulating their migration and epithelial repair in TB
Bose-Einstein condensates with attractive interactions on a ring
Considering an effectively attractive quasi-one-dimensional Bose-Einstein
condensate of atoms confined in a toroidal trap, we find that the system
undergoes a phase transition from a uniform to a localized state, as the
magnitude of the coupling constant increases. Both the mean-field
approximation, as well as a diagonalization scheme are used to attack the
problem.Comment: 4 pages, 4 ps figures, RevTex, typographic errors correcte
Dimensional and Temperature Crossover in Trapped Bose Gases
We investigate the long-range phase coherence of homogeneous and trapped Bose
gases as a function of the geometry of the trap, the temperature, and the
mean-field interactions in the weakly interacting limit. We explicitly take
into account the (quasi)condensate depletion due to quantum and thermal
fluctuations, i.e., we include the effects of both phase and density
fluctuations. In particular, we determine the phase diagram of the gas by
calculating the off-diagonal one-particle density matrix and discuss the
various crossovers that occur in this phase diagram and the feasibility of
their experimental observation in trapped Bose gases.Comment: One figure added, typos corrected, refernces adde
Mermin-Ho vortex in ferromagnetic spinor Bose-Einstein condensates
The Mermin-Ho and Anderson-Toulouse coreless non-singular vortices are
demonstrated to be thermodynamically stable in ferromagnetic spinor
Bose-Einstein condensates with the hyperfine state F=1. The phase diagram is
established in a plane of the rotation drive vs the total magnetization by
comparing the energies for other competing non-axis-symmetric or singular
vortices. Their stability is also checked by evaluating collective modes.Comment: 4 pages, 4 figure
Damped Bogoliubov excitations of a condensate interacting with a static thermal cloud
We calculate the damping of condensate collective excitations at finite
temperatures arising from the lack of equilibrium between the condensate and
thermal atoms. We neglect the non-condensate dynamics by fixing the thermal
cloud in static equilibrium. We derive a set of generalized Bogoliubov
equations for finite temperatures that contain an explicit damping term due to
collisional exchange of atoms between the two components. We have numerically
solved these Bogoliubov equations to obtain the temperature dependence of the
damping of the condensate modes in a harmonic trap. We compare these results
with our recent work based on the Thomas-Fermi approximation.Comment: 9 pages, 3 figures included. Submitted to PR
A clinicopathological analysis of ovarian tumours
We performed a retrospective analysis of patients with ovarian tumors who were admitted to the Aga Khan University Hospital from January 1985 to December 1989. Sixty one cases were reviewed. Mean age of the whole group was 44 years. Majority of the patients presented with abdominal pain and distention. Most frequent physical finding was a palpable mass on pelvic or abdominal examination. Overall these patients had a higher incidence of breast cancer than expected in the general population. Two-thirds of the tumors were malignant. Comparison of the patients with malignancy against those with benign tumors failed to show any correlation with parity. Majority of the patients with malignant disease were above forty and had ultrasound showing a cystic mass over 10 cms in size. Cancer was mostly epithelial in origin, with widespread disease (stage III or IV) at the time of presentation. Benign tumors, mostly of germ cell type, were predominantly seen in patients under the age of forty with ultrasound showing cystic mass of any size from under 5 cms to over 10 cms
Kinetic Theory of Collective Excitations and Damping in Bose-Einstein Condensed Gases
We calculate the frequencies and damping rates of the low-lying collective
modes of a Bose-Einstein condensed gas at nonzero temperature. We use a complex
nonlinear Schr\"odinger equation to determine the dynamics of the condensate
atoms, and couple it to a Boltzmann equation for the noncondensate atoms. In
this manner we take into account both collisions between
noncondensate-noncondensate and condensate-noncondensate atoms. We solve the
linear response of these equations, using a time-dependent gaussian trial
function for the condensate wave function and a truncated power expansion for
the deviation function of the thermal cloud. As a result, our calculation turns
out to be characterized by two dimensionless parameters proportional to the
noncondensate-noncondensate and condensate-noncondensate mean collision times.
We find in general quite good agreement with experiment, both for the
frequencies and damping of the collective modes.Comment: 10 pages, 8 figure
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