Effect of complex chelate fertilizer on root tissue functional activity and performance grain of wheat soft winter

The article is devoted investigations the effects of foliar treatment complex fertilizers with chelates оn functional activity in tissues of roots in connection with redox potential of cells and kinetics of release of protons from the root cells, as well as enzymatic activity: catalase, peroxidase, ATPase in tissues of roots and grain productivity of plant winter wheat varieties Smuglanka. Study shows that non-leaf feeding complex fertilizers chelates Fiziozhivlin+P, Breksil Mix, Master 18.18.18 and Plantafol 5.15.45 regulates the metabolism of a plant, including affecting the functional capacity of the tissues of roots, as reflected in the increasing activity of redox potential of cells and inhibition of the kinetics of release of protons from the root cells. Increasing the ATPase activity of the root tissues indicates a growing share and maintaining active biosynthetic and regulatory of processes under the influence of chelated fertilizers, in particular, of biosynthesis of organic molecules, that associated with increased the biomass of wheat plants according from the data obtained. Determination of the activity of the antioxidant ferments: catalase and peroxidase showed increased activity of catalase (І.ІІ.І.6) under foliar fertilizer processing Fiziozhivlin+P and of peroxidase (І.ІІ.І.7) on 32 % in contrast of the control roots plants. Our studies have shown increase in grain productivity with by foliar treatment of chelate complex fertilizers: Fiziozhivlin+P, Breksil Mix, Master and Plantafol that increased by 5,9; 6,4; 6,0 and 5,1 t/ha, respectively. Thus, treatment of complex chelate fertilizer improves the functional activity of the tissues of roots, promoting the growth of their potential absorption capacity, supporting high plant energy balance of the body, promotes the resistance of wheat to the effects of pathogenic factors and eventually leads to an increase of grain productivity

A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes’ toxicity

Octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to difficulty to control the hydrolysis of initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6]

Patterns of Forming the Urban Surface Deposited Sediments

The contemporary sedimentation processes participate in the formation of fluxes of the solid substances in an urban area, forming together a source of pollution, transit and depositing media. The patterns of forming the urban surface deposited sediments were determined on the example of Russian metropolis Nizhny Novgorod. Two schemes of the research were implemented in residential districts of the city in the summer field season 2018. The first research design scheme represented a detailed survey of residential quarters of the city. It included a collection of 25 samples of environmental compartments from five residential quarters with multi-storey buildings. The sampling was conducted in various functional landscape parts at the courtyard and facade areas. Each sample was separated into particle size fractions. Chemical and mineral analysis was performed in each granulometric subsample of the collected samples. The second scheme represented the urban geochemical study based on sampling the sediments from local surface depressed zones of microrelief in the city. The 40 samples were collected at the territory of the city on an irregular grid. The sampling was carried out in residential areas in blocks with multi-storey buildings. One sample represented a combined sample of sediments from local surface zones of microrelief by 3-5 localizations from the area of the block. Chemical analysis of the collected samples was conducted. The maximum content of dust (0.002-0.01 mm) 39% was found in soil, while the lower mean dust content was found in the samples of sediment from local surface depressed zones of microrelief (30 %) and in the road deposited sediments (30 %). The mineral composition of soil and sediment in Nizhny Novgorod is represented by quartz sand (approx. 55 %). In the samples of sediments, the minerals' content is basically characteristic for acid and metasomatic rocks. Building materials' content in the sediments reaches up to 20%. The maximum organic matter content was found in fine dust fraction 2-10 microns 21% in soils and 5% on the roads. Differentiation of the mineral content in the samples is observed for the various particle size fractions and different functional parts of the quarters. The highest content of metals of anthropogenic association (such as Pb, Zn and Cu) was found in the dust fraction. The Pb and Zn concentrations in samples of sediment of depressed areas of microrelief and road dust were significantly lower than in the soil. © Published under licence by IOP Publishing Ltd.Russian Science Foundation, RSF: 18-77-10024The study was supported by Russian Science Foundation (grant No. 18-77-10024)

COST 296 scientific results designed for operational use

The main objective of the COST 296 Action «Mitigation of Ionospheric Effects on Radio Systems» is the establishment/ improvement of ionospheric services by coordinating the development of specific algorithms, models, and tools capable of operating in a near-real-time mode. Key elements of these activities are contributions related to monitoring, modelling, and imaging of customer-relevant ionospheric quantities. COST stimulates, coordinates, and supports Europe’s goals of development and global cooperation by providing high quality information and knowledge of ionospheric and plasmaspheric conditions enabling high quality and reliable operation of radio systems. It also provides a platform for sharing such tools as algorithms or models, and for the joint development of advanced technologies. It takes advantage of many national and European service initiatives, for example DIAS (http://dias.space.noa.gr), SWACI (http://w3swaci.dlr.de), ESWUA (http://www.eswua.ingv.it/ingv), RWC-Warsaw (http://www.cbk.waw.pl/rwc), the COST Prompt Ionospheric Database http://www.wdc.rl.ac.uk/cgibin/ digisondes/cost_database.pl, http://www.izmiran.ru/services, and others. Existing national capabilities are taken into account to develop synergies and avoid duplication. The enhancement of environment monitoring networks and associated instrumentation yields mutual advantages for European and regional services specialized for local user needs. It structurally increases the integration of limited-area services, and generates a platform employing the same approach to each task differing mostly in input and output data. In doing so it also provides a complementary description of the environmental state within issued information, as well as providing a platform for interaction among local end users, who define what kind of information they need, for system providers, who finalize the tools necessary to obtain required information, and for local service providers, who do the actual processing of data, tailoring it to specific users’ needs. Such an initiative creates a unique opportunity for small national services to consolidate their product design so that is no longer limited to their own activity, but can serve the wider European services. The development and improvement of techniques for mitigating ionospheric effects on radio systems by the COST 296 Action prepared those services that implemented the new design techniques for the newly announced EU and ESA policy-Space Situation Awareness (SSA). COST 296 developments applied to nowcasting and forecasting services are an essential input to the Operational SSA Ionosphere

Ionospheric Modelling using GPS to Calibrate the MWA. II : Regional ionospheric modelling using GPS and GLONASS to estimate ionospheric gradients

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Publications of the Astronomical Society of Australia (PASA), after peer review and technical editing by the publisher. The version of record is available on line at https://doi.org/10.1017/pasa.2016.22 COPYRIGHT: © Astronomical Society of Australia 2016.We estimate spatial gradients in the ionosphere using the Global Positioning System (GPS) and GLONASS (Russian global navigation system) observations, utilising data from multiple GPS stations in the vicinity of Murchison Radio-astronomy Observatory (MRO). In previous work the ionosphere was characterised using a single-station to model the ionosphere as a single layer of fixed height and this was compared with ionospheric data derived from radio astronomy observations obtained from the Murchison Widefield Array (MWA). Having made improvements to our data quality (via cycle slip detection and repair) and incorporating data from the GLONASS system, we now present a multi-station approach. These two developments significantly improve our modelling of the ionosphere. We also explore the effects of a variable-height model. We conclude that modelling the small-scale features in the ionosphere that have been observed with the MWA will require a much denser network of Global Navigation Satellite System (GNSS) stations than is currently available at the MRO.Peer reviewe

Active voltage damping method with negative DC link current feedback in electric and hybrid electric transmissions

Electric and hybrid electric transmissions in traction drive have a limited capacity power source. Since the traction drive operates in the torque source mode, the DC link voltage becomes unstable and goes into oscillatory mode. This leads to the software protection reaction which prevents the traction inverter overvoltage breakdown. The transition boundary to the oscillatory mode is determined by the power and the value of the capacitance installed in the electric transmission DC link. To increase reliability of the traction inverters, large-capacity electrolytic capacitors are replaced with smallcapacity film capacitors which makes the system more prone to oscillations. To solve this problem, active damping methods are used allowing changing the engine dynamic characteristics by means of the control system. The software methods with power and torque proportional control are most widely used. Proportional power control is the simplest method in which the traction drive simulates an RL load. The torque proportional control method adjusts the torque reference according to the change in the DC link voltage. This paper proposes a new negative DC link feedback method. In this case, the torque is adjusted dynamically depending on the current consumed by the traction inverter from the electric transmission common DC link. Mathematical modeling methods were used to compare the known and proposed methods of DC link voltage active damping. Mathematical models have been developed in the MATLAB Simulink environment which makes it possible to investigate the damping capacity at various values of the power consumed by the traction inverter. It is shown that the proposed method with negative DC link current feedback demonstrated tuning simplicity. In comparison with proportional power and torque control methods, the proposed option is robust when setting parameters, provides a large damping coefficient over the entire range of traction drive power, and has a short duration of the transient process. The proposed method can be used to suppress DC link voltage oscillations on any type of hybrid electric and all-electric vehicles traction inverters and ensures stable and reliable equipment operation

Risk Factors of Portal Vein Thrombosis in Patients with Different Child-Pugh Classes Liver Cirrhosis

Aim: to evaluate the frequency of portal vein thrombosis (PVT) and build predictive models of the development of PVT for patients with liver cirrhosis (LC) of A and B/C classes by Child-Pugh.Materials and methods. Research design is a case-control. The Case group included 130 patients with newly diagnosed PVT not caused by invasive hepatocellular carcinoma (HCC); 29 patients were assigned to class A, 101 patients were assigned to class B/C. From the database of cirrhotic patients without PVT 60 Controls for class A and 205 for B/C were selected using sratified randomization by sex, age and etiology of cirrhosis. The Mann-Whitney U-test and Pearson's chi-squared test were used to compare the groups. Odds ratios (OR) and 95 % confidence intervals (95 % CI) were calculated. Logistic regression models are constructed with the separation of the sample into training and test (0.7; 0.3). The operational characteristics of the models were calculated on the test sample; ROC analysis was carried out, the area under the ROC curve (AUC) was calculated.Results. The overall frequency of PVT was 4.1 % (95 % CI 2.7-5.8 %) in class A and 10.4 % (95 % CI 8.5-12.5 %) class B/C. Patients with class A and B/C PVT differed from the corresponding controls by more severe portal hypertension: the frequency of bleeding / number of interventions on varices compared with the control were 41/45 % vs. 7/8 % (p < 0.001) for class A and 25.7/30.7 % vs. 16.1/16.1 % (p < 0.05) for class B/C, ascites frequency was 24 % vs. 8 % (p < 0.05) for class A and 89.1 % vs. 68.3 % (p < 0.001) for class B/C. The cutoff by the portal vein diameter was the same for both classes — 13.4 mm; the spleen length was similar and amounted 17.5 mm for class A, 17.1 mm for class B/C. Patients with PVT differed from the corresponding controls by neutrophil-to-lymphocyte ratio: class A 2.33 (1.82; 3.61) vs. 1.76 (1.37; 2.20), p < 0.01, class B/C 2.49 (1.93; 3.34) vs. 2.15 (1.49; 3.26), p < 0.05. Patients of class B/C had a higher incidence of newly diagnosed malignant tumors - 23.8% (primarily HCC that does not invade the portal vein), compared with control and cases of class A - 6.3 % and 3 % (p < 0.05), respectively. The best model for class A included variceal bleeding, ascites, portal vein diameter, absolute number of neutrophils, for class B — ascites, spleen length, portal vein diameter, malignant tumors / local factors; sensitivity, specificity, accuracy and AUC were 79.3 %, 90 %, 86.5 %, 0.897 and 73.3 %, 68.3 %, 69.9 %, 0.789, respectively.Conclusion. Independently of the Child-Pugh class of LC, the main risk factor for PVT is severe portal hypertension

Effects of early neonatal proinflammatory stress on the expression of BDNF transcripts in the brain regions of prepubertal male rats

Early postnatal proinflammatory stress provokes behavioral impairments in adulthood; however, underlying mechanisms are still elusive. Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuroplastic changes in health as well as at pathology. The BDNF gene is transcribed to exon-specific mRNAs and the pattern of their expression depends on stimulus. We suggest that disturbances of exonspecific BDNF mRNA expression in the brain regions after stress induced by proinflammatory stimuli in early postnatal period could be one of the underlying mechanisms of consequent behavioral impairments. Thus, the aim of the study was to investigate the effects of proinflammatory stress in early postnatal ontogeny on the expression of BDNF and the patterns of expression of the BDNF gene in the neocortex and hippocampus of prepubertal male rats. The proinflammatory stress was induced by subcutaneous administration of bacterial lipopolysaccharide (LPS) to rat pups on postnatal days 3 and 5, while BDNF expression was analyzed in 36-day-old rats. BDNF polypeptide concentration was estimated by means of an enzyme-linked immunosorbent assay, while quantitative polymerase chain reaction followed by reverse transcription was used to detect exon-specific BDNF mRNA expression. The levels of BDNF and transcripts, containing common exon IX were similar in the control and LPS-treated rats. In the rats treated with LPS, the level of BDNF mRNA, containing exon IV, was lower in the neocortex, but not in the hippocampus. No changes in the expression of the transcripts containing exons I and VI were observed in any brain structure studied. We suggest that specific alterations in BDNF expression may be involved in the susceptibility to the development of behavioral impairments of animals subjected to early proinflammatory stress

MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis

Aim. To assess the level of microRNA (miR) -21, -22, -126, -221 in patients with coronary artery disease (CAD) with borderline coronary artery stenosis depending on comorbidities and sex.Material and methods. We examined 37 patients with class 1-3 stable CAD aged 49-59 years with borderline (40-70%) coronary artery stenosis. The relative level of miRNA was determined using real-time polymerase chain reaction. Statistical analysis was performed using the non-parametric Mann-Whitney U-test. P<0,05 were considered statistically significant. Results. The miR-221 level was higher in the group of patients with stable CAD with borderline coronary artery stenosis with a metabolically unhealthy obesity (MUO) phenotype, but without diabetes (p=0,042). The level of miR-22 and miR-126 was higher in the group of patients with stable CAD phenotype with borderline stenosis and diabetes (p=0,007 and p=0,034, respectively). The analysis of miR levels in stable CAD patients depending on sex, without taking into account the phenotype, found that miR-21 and miR-221 values were higher in men (p=0,021 and p=0,014, respectively). The study of the sex characteristics of miR content in relation to different phenotypes revealed an increase of miR22 levels in men with MUO and diabetes (p=0,048) and an increase of miR-126 levels in women with concomitant diabetes in the comparison both with patients without MUO and diabetes (p=0,018), as well as with MUO and without diabetes (p=0,007). Conclusion. The study of the miRNA level in patients with CAD with borderline coronary artery stenosis is of great interest and reflects a promising direction in diagnosis based on comorbid pathology. Keywords: miRNA, obesity phenotypes, coronary artery disease, borderline coronary artery stenosis. Relationships and Activities: none. 1Novosibirsk State Medical University, Novosibirsk; 2Federal Research Center of Fundamental and Translational Medicine, Novosibirsk; 3E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia.><0,05 were considered statistically significant.Results. The miR-221 level was higher in the group of patients with stable CAD with borderline coronary artery stenosis with a metabolically unhealthy obesity (MUO) phenotype, but without diabetes (p=0,042). The level of miR-22 and miR-126 was higher in the group of patients with stable CAD phenotype with borderline stenosis and diabetes (p=0,007 and p=0,034, respectively). The analysis of miR levels in stable CAD patients depending on sex, without taking into account the phenotype, found that miR-21 and miR-221 values were higher in men (p=0,021 and p=0,014, respectively). The study of the sex characteristics of miR content in relation to different phenotypes revealed an increase of miR22 levels in men with MUO and diabetes (p=0,048) and an increase of miR-126 levels in women with concomitant diabetes in the comparison both with patients without MUO and diabetes (p=0,018), as well as with MUO and without diabetes (p=0,007).Conclusion. The study of the miRNA level in patients with CAD with borderline coronary artery stenosis is of great interest and reflects a promising direction in diagnosis based on comorbid pathology