An adaptive distributed Intrusion detection system architecture using multi agents

Intrusion detection systems are used for monitoring the network data, analyze them and find the intrusions if any. The major issues with these systems are the time taken for analysis, transfer of bulk data from one part of the network to another, high false positives and adaptability to the future threats. These issues are addressed here by devising a framework for intrusion detection. Here, various types of co-operating agents are distributed in the network for monitoring, analyzing, detecting and reporting. Analysis and detection agents are the mobile agents which are the primary detection modules for detecting intrusions. Their mobility eliminates the transfer of bulk data for processing. An algorithm named territory is proposed to avoid interference of one analysis agent with another one. A communication layout of the analysis and detection module with other modules is depicted. The inter-agent communication reduces the false positives significantly. It also facilitates the identification of distributed types of attacks. The co-ordinator agents log various events and summarize the activities in its network. It also communicates with co-ordinator agents of other networks. The system is highly scalable by increasing the number of various agents if needed. Centralized processing is avoided here to evade single point of failure. We created a prototype and the experiments done gave very promising results showing the effectiveness of the system

A critical review on the performance of pile-supported rail embankments under cyclic loading: Numerical modeling approach

Searching for economical and practical solutions to increase any transport substructures protection and stability is critical for ensuring the long-term viability and adequate load-bearing capacity. Piles are increasingly being used as an economical and environmentally sustainable solution to enhance the strength of soft subgrade soils on which embankments are raised. As per the available literature, there are two main strategies used to explain railway embankments performance: experimental approaches and numerical simulations on a broad scale. The purpose of this study is to examine the state-of-the-art literature on numerical modeling methods adopted to assess the performance of pile-supported rail embankments subjected to cyclic loading. The paper addresses the main results from various numerical methods to explain the appropriate mechanisms associated with the load deformation response. It also presents the key issues and drawbacks of these numerical methods concerning rail embankment development while outlining the specific shortcomings and research gaps relevant to enhanced future design and analysis. (c) 2021 by the authors. Licensee MDPI, Basel, Switzerland

Observations on the age and growth of Varicorhinus damascinus (Val.) in Tigris river at Salahuldin province – Iraq

Age and growth of Varicorhinus damascinus (Val.) in Tigris river at Salahuldin province have been investigated. Monthly samples were taken during the period from September 1999 to August 2000, using small-meshed gill nets. The age data showed that there were six age groups and the dominant age groups were (III – IV) for both sexes. The results of the present study revealed that the increment in length of V. damascinus at the sites of study showed a tendency to decrease with the increase in age, after the third year of life in both sexes. The length-weight relationship of males and females were calculated and demonstrated in a straight line logarithmic formula, as follows: Log W = 1.5404 + 2.6885 log L for males r = 0.95 (P > 0.05) Log W = 1.6723 + 2.7877 log L for females r = 0.77 (P > 0.05) The values of the regression coefficient (b) indicated that the growth of both sexes of V. damascinus was allometric.

Establishing a COVID-19 lemmatized word list for journalists and ESP learners

The aim of this research is two-fold; first, to explore the most frequent COVID-19 inspired words in medical news reporting contexts, and second, to classify them into different categories. This paper adopts a corpus-based approach to build a lemmatized academic word list (AWL) inspired by the COVID-19 pandemic. Factiva was used to retrieve the pandemic-related articles published in News Rx from January 1 - October 31, 2020. A total number of 18,249,093-word corpus was compiled. The corpus linguistic software program Wordsmith (WS-6) (Scott, 2012) was used to generate a word list based on the complied corpus. Subsequent to compiling, lemmatizing, and analyzing the AWL, six categories were identified, namely, acronyms and abbreviation, diseases, COVID-19, biology, medicine, and scientific disciplines, all of which are of essential use for media workers, ESP learners of journalism, medicine, nursing, pharmacy, and allied health sciences. Building such a discipline-specific glossary will be of special pedagogical value for health journalists, textbook writers and curriculum designers, instructors, and ESP learners in the health sciences field. One of the major contributions of this research is establishing lemmas of a large set of AWL. This set can be utilized by news media workers, health communication specialists, and ESP learners. Lemmatization will ensure rapid dissemination of the word list and its integration in the linguistic system through derivation and other word-formation processes

Non-Steroidal Anti-Inflammatory Drugs and Antibiotics Prescription Trends at a Central West Bank Hospital

Objectives: We aimed to reliably describe the pattern of outpatient prescription of non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics (ATBs) at a central hospital in the West Bank, Palestine.Methods: This was a retrospective, cross-sectional study investigating a cohort of 2,208 prescriptions ordered by outpatient clinics and the emergency room over one year in Beit Jala Hospital in Bethlehem, West Bank. The orders were analysed for the rate and types of NSAIDs and ATBs utilised, and the appropriateness of these drugs to the diagnosis. Results: Of the total prescriptions, 410 contained NSAIDs (18.6%), including diclofenac (40.2%), low dose aspirin (23.9%), ibuprofen (17.8%) and indomethacin (15.1%). A minority of these prescriptions contained a combination of these agents (2.5%). Only one prescription contained cyclooxyeganse-2 inhibitors (0.2%). The appropriateness of NSAID use to the diagnosis was as follows: appropriate (58.3%), inappropriate (14.4%) and difficult to tell (27.3%). The rate of ATB use was 30.3% (669 prescriptions). The ATBs prescribed were amoxicillin (23.3%), augmentin (14.3%), quinolones (12.7%), first and second generation cephalosporins (9.4% and 12.7%, respectively) and macrolides (7.2%). ATB combinations were identified in 9.4%, with the most common being second-generation cephalopsorins and metronidazole (4.3%). Regarding the appropriateness of prescribing ATBs according to the diagnosis, it was appropriate in 44.8%, inappropriate in 20.6% and difficult to tell in 34.6% of the prescriptions. Conclusion: These findings revealed a relatively large number and inappropriate utilisation of ATBs and NSAIDs. An interventional programme needs to be adopted to reinforce physicians’ knowledge of the rational prescription of these agents

Exercise protects against obesity induced semen abnormalities via downregulating stem cell factor, upregulating Ghrelin and normalizing oxidative stress

Increased oxidative stress and hormonal imbalance have been hypothesized to underlie infertility in obese animals. However, recent evidence suggests that Ghrelin and Stem Cell Factor (SCF) play an important role in fertility, in lean individuals. Therefore, this study aimed at investigating whether changes in the levels of Ghrelin and SCF in rat testes underlie semen abnormal parameters observed in obese rats, and secondly, whether endurance exercise or Orlistat can protect against changes in Ghrelin, SCF, and/or semen parameters in diet induced obese rats. Obesity was modelled in male Wistar rats using High Fat Diet (HFD) 12-week protocol. Eight week-old rats (n=40) were divided into four groups, namely, Group I: fed with a standard diet (12 % of calories as fat); Group II: fed HFD (40 % of calories as fat); Group III: fed the HFD with a concomitant dose of Orlistat (200 mg/kg); and Group IV: fed the HFD and underwent 30 min daily swimming exercise. The model was validated by measuring the levels of testosterone, FSH, LH, estradiol, leptin, triglycerides, total, HDL, and LDL cholesterol, and final change in body weight. Levels were consistent with published obesity models (see Results). As predicted, the HFD group had a 76.8 % decrease in sperm count, 44.72 % decrease in sperm motility, as well as 47.09 % increase in abnormal sperm morphology. Unlike the control group, in the HFD group (i.e. obese rats) Ghrelin mRNA and protein were elevated, while SCF mRNA and protein were diminished in the testes. Furthermore, in the HFD group, SOD and GPx activities were significantly reduced, 48.5±5.8 % (P=0.0012) and 45.6±4.6 % (P=0.0019), respectively, while TBARS levels were significantly increased (112.7±8.9 %, P≤0.0001). Finally, endurance exercise training and Orlistat administration individually and differentially protected semen parameters in obese rats. The mechanism includes, but is not limited to, normalizing the levels of Ghrelin, SCF, SOD, GPx and TBARS. In rat testes, diet induced obesity down regulates SCF expression, upregulates Ghrelin expression, and deteriorate oxidative stress levels, which are collectively detrimental to semen parameters. Exercise, and to a lesse r extent Orlistat administration, protected effectively against this detrimental effect

Distribution of some Heavy Metals Pollution Caused byAl- Daura Refinery in the Surrounding Region

Due to the higher increase in the oil industry activities in Iraq, since there are a little information of the environmental status of the areas around the refinery locations, and the concerns of a possible environmental pollution that will cause health and life threats to living organisms, this study was carried out.To understand the status of heavy metals pollution in areas inside and surrounding Al-Daura refinery activities, (17) testing locations were chosen, ten locationsoutsidethe refinery and sevenlocationsinside it.One additional location was chosen in a rural (control) area, in the University of Baghdad, to compare between the heavy metals concentration in the study area and a sample from the rural area not affected by the pollution. The soil samples have been taken from (5 and 60 cm) depth from the top surface of the soil. Three samples were taken from each depth for each location to take an average of results.All the samples of soil were taken during the period from Dec/2010 to Feb/2011.The experimental work has been includes the heavy metals concentrations, such as Zinc, Nickel, Lead and Cadmium, have been measured at each selected depth for each testing locations.The results indicate that the mean concentration of Zn and Ni is (62.4 µg/g) and (100.5 µg/g) respectively and this valuesexceeded the mean allowable value by (Alloway, 1995 [2]; Kabata-Pendias and Pendias, 1992 [6]).The most concentrations of Zn, Ni and Pb, with some exceptions, accumulate at the top soil and decrease with the depth except Cd

Identification of Genes and Pathways Regulated by Lamin A in Heart

Background Mutations in the LMNA gene, encoding LMNA (lamin A/C), causes distinct disorders, including dilated cardiomyopathies, collectively referred to as laminopathies. The genes (coding and noncoding) and regulatory pathways controlled by LMNA in the heart are not completely defined. Methods and Results We analyzed cardiac transcriptome from wild-type, loss-of-function (Lmna-/-), and gain-of-function (Lmna-/- injected with adeno-associated virus serotype 9 expressing LMNA) mice with normal cardiac function. Deletion of Lmna (Lmna-/-) led to differential expression of 2193 coding and 629 long noncoding RNA genes in the heart (q<0.05). Re-expression of LMNA in the Lmna-/- mouse heart, completely rescued 501 coding and 208 non-coding and partially rescued 1862 coding and 607 lncRNA genes. Pathway analysis of differentially expressed genes predicted activation of transcriptional regulators lysine-specific demethylase 5A, lysine-specific demethylase 5B, tumor protein 53, and suppression of retinoblastoma 1, paired-like homeodomain 2, and melanocyte-inducing transcription factor, which were completely or partially rescued upon reexpression of LMNA. Furthermore, lysine-specific demethylase 5A and 5B protein levels were increased in the Lmna-/- hearts and were partially rescued upon LMNA reexpression. Analysis of biological function for rescued genes identified activation of tumor necrosis factor-α, epithelial to mesenchymal transition, and suppression of the oxidative phosphorylation pathway upon Lmna deletion and their restoration upon LMNA reintroduction in the heart. Restoration of the gene expression and transcriptional regulators in the heart was associated with improved cardiac function and increased survival of the Lmna-/- mice. Conclusions The findings identify LMNA-regulated cardiac genes and their upstream transcriptional regulators in the heart and implicate lysine-specific demethylase 5A and B as epigenetic regulators of a subset of the dysregulated genes in laminopathies

Unveiling the interplay between NSAID-induced dysbiosis and autoimmune liver disease in children: insights into the hidden gateway to autism spectrum disorders. Evidence from ex vivo, in vivo, and clinical studies

Autism spectrum disorders (ASD) represent a diverse group of neuropsychiatric conditions, and recent evidence has suggested a connection between ASD and microbial dysbiosis. Immune and gastrointestinal dysfunction are associated with dysbiosis, and there are indications that modulating the microbiota could improve ASD-related behaviors. Additionally, recent findings highlighted the significant impact of microbiota on the development of autoimmune liver diseases, and the occurrence of autoimmune liver disease in children with ASD is noteworthy. In the present study, we conducted both an in vivo study and a clinical study to explore the relationship between indomethacin-induced dysbiosis, autoimmune hepatitis (AIH), and the development of ASD. Our results revealed that indomethacin administration induced intestinal dysbiosis and bacterial translocation, confirmed by microbiological analysis showing positive bacterial translocation in blood cultures. Furthermore, indomethacin administration led to disturbed intestinal permeability, evidenced by the activation of the NLRP3 inflammasomes pathway and elevation of downstream biomarkers (TLR4, IL18, caspase 1). The histological analysis supported these findings, showing widened intestinal tight junctions, decreased mucosal thickness, inflammatory cell infiltrates, and collagen deposition. Additionally, the disturbance of intestinal permeability was associated with immune activation in liver tissue and the development of AIH, as indicated by altered liver function, elevated ASMA and ANA in serum, and histological markers of autoimmune hepatitis. These results indicate that NSAID-induced intestinal dysbiosis and AIH are robust triggers for ASD existence. These findings were further confirmed by conducting a clinical study that involved children with ASD, autoimmune hepatitis (AIH), and a history of NSAID intake. Children exposed to NSAIDs in early life and complicated by dysbiosis and AIH exhibited elevated serum levels of NLRP3, IL18, liver enzymes, ASMA, ANA, JAK1, and IL6. Further, the correlation analysis demonstrated a positive relationship between the measured parameters and the severity of ASD. Our findings suggest a potential link between NSAIDs, dysbiosis-induced AIH, and the development of ASD. The identified markers hold promise as indicators for early diagnosis and prognosis of ASD. This research highlights the importance of maintaining healthy gut microbiota and supports the necessity for further investigation into the role of dysbiosis and AIH in the etiology of ASD.Peer Reviewe

Atomic Resonance and Scattering

Contains reports on nine research projects.National Science Foundation (Grant PHY79-09743)National Science Foundation (Grant PHY82-10486)Joint Services Electronics Program (Contract DAAG29-83-K-0003)U.S. Navy - Office of Naval Research (Contract N00014-79-C-0183)National Bureau of Standards (Grant NB83-NAHA-4058)National Science Foundation (Grant CHE79-02967-A04)National Science Foundation (Grant PHY83-07172)Joint Services Electronics Program (Grant DAAG29-83-K-0003