Energetic particles observed by ISEE-1 and ISEE-2 in a cusp diamagnetic cavity on 29 September 1978

International audienceObservations by the ISEE-1 and ISEE-2 spacecraft on 29 September 1978 show large CEP (Cusp Energetic Particle) fluxes while passing through the dayside magnetospheric cusp in near coincident orbits. The event was observed around 11:00 MLT between roughly 12:30 and 13:00 UT by ISEE-1 and 12:00 and 13:00 UT by ISEE-2. During these periods, both electron and ion fluxes increased by more than two orders of magnitude, with the electron flux showing a strong peak at a pitch angle of 90°. The solar wind was ~710 km s?1 and the Dst was ~?200 nT, suggesting the occurrence of a strong geomagnetic storm. The ISEE-1 and ISEE-2 observations, however, show no time-energy dispersion of the CEPs, leading us to believe that these particles could not be the result of substorm processes in the magnetotail. The local magnetic field was depressed and extremely turbulent. Changes in the magnitude of the magnetic field anticorrelate closely to variations of the electron flux. The observations in electron flux peaking at 90° and the close anticorrelation between the local magnetic field strength and electron flux are unique and provide evidence of a potential local source for these energetic particles

Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats

The renin–angiotensin system (RAS) is involved in the pathogenesis of insulin sensitivity (IS). The role of RAS in insulin resistance and muscular circulation has yet to be elucidated. Therefore, this study sought to determine the mechanisms of angiotensin II receptor blockers (ARBs) and/or diuretics on IS and capillary density (CD) in fructose-fed rats (FFRs). Sprague-Dawley rats were fed either normal chow (control group) or fructose-rich chow for 8 weeks. For the last 4 weeks, FFRs were allocated to four groups: an FFR group and groups treated with the thiazide diuretic hydrochlorothiazide (HCTZ), with the ARB losartan, or both. IS was evaluated by the euglycemic hyperinsulinemic glucose clamp technique at week 8. In addition, CD in the extensor digitorum longus muscle was evaluated. Blood pressure was significantly higher in the FFRs than in the controls. HCTZ, losartan and their combination significantly lowered blood pressure. IS was significantly lower in the FFR group than in the controls and was even lower in the HCTZ group. Losartan alone or combined with HCTZ significantly increased IS. In all cases, IS was associated with muscular CD, but not with plasma adiponectin or lipids. These results indicate that losartan reverses HCTZ-exacerbated insulin resistance, which can be mediated through the modulation of muscular circulation in rats with impaired glucose metabolism

Anxiety and Depression in Adults with Autism Spectrum Disorder: A Systematic Review and Meta-analysis

Adults with autism spectrum disorder (ASD) are thought to be at disproportionate risk of developing mental health comorbidities, with anxiety and depression being considered most prominent amongst these. Yet, no systematic review has been carried out to date to examine rates of both anxiety and depression focusing specifically on adults with ASD. This systematic review and meta-analysis examined the rates of anxiety and depression in adults with ASD and the impact of factors such as assessment methods and presence of comorbid intellectual disability (ID) diagnosis on estimated prevalence rates. Electronic database searches for studies published between January 2000 and September 2017 identified a total of 35 studies, including 30 studies measuring anxiety (n = 26 070; mean age = 30.9, s.d. = 6.2 years) and 29 studies measuring depression (n = 26 117; mean age = 31.1, s.d. = 6.8 years). The pooled estimation of current and lifetime prevalence for adults with ASD were 27% and 42% for any anxiety disorder, and 23% and 37% for depressive disorder. Further analyses revealed that the use of questionnaire measures and the presence of ID may significantly influence estimates of prevalence. The current literature suffers from a high degree of heterogeneity in study method and an overreliance on clinical samples. These results highlight the importance of community-based studies and the identification and inclusion of well-characterized samples to reduce heterogeneity and bias in estimates of prevalence for comorbidity in adults with ASD and other populations with complex psychiatric presentations

Freisetzung und Reaktionen von N-Sulfonylalkylaminen mit reaktiven #pi#-Elektronensystemen

SIGLEAvailable from TIB Hannover: DW 3734 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman