A CLASSIFICATION MODEL FOR THE INFERENCE OF SPATIAL PRECISION OF OPENSTREETMAP BUILDINGS WITH INTRINSIC INDICATORS

To evaluate the quality of OSM data, similarities between OSM features and their homologous features represented in a reference database are relevant metrics. However, reference databases do not exist everywhere or are not freely available. Thus, having data quality assessment methods that rely only on intrinsic indicators (i.e. based on data itself without considering external information) would be useful in these cases. This article specifically uses the radial distance as a target quality metric to measure the quality of shapes. Its aim is to build a random-forest based classification method that reconstructs whether this distance is higher or lower than a specified threshold, using only intrinsic indicators as inputs. The classification algorithm is evaluated on a first dataset by computing the ROC (Receiver Operating Characteristic) curve and using the AUC (Area Under Curve) as an evaluation metric. The transferability of the resulting algorithm is then evaluated by measuring its performance on a second, distinct dataset. The experiments show that the algorithm performs reasonably well on both the initial and the second dataset, and that intrinsic indicators give relevant information to infer comparison-based shape quality (i.e. the radial distance)

Outcomes following autologous hematopoietic stem cell transplant for patients with relapsed Wilms' tumor: a CIBMTR retrospective analysis.

Despite the marked improvement in the overall survival (OS) for patients diagnosed with Wilms' tumor (WT), the outcomes for those who experience relapse have remained disappointing. We describe the outcomes of 253 patients with relapsed WT who received high-dose chemotherapy (HDT) followed by autologous hematopoietic stem cell transplant (HCT) between 1990 and 2013, and were reported to the Center for International Blood and Marrow Transplantation Research. The 5-year estimates for event-free survival (EFS) and OS were 36% (95% confidence interval (CI); 29-43%) and 45% (95 CI; 38-51%), respectively. Relapse of primary disease was the cause of death in 81% of the population. EFS, OS, relapse and transplant-related mortality showed no significant differences when broken down by disease status at transplant, time from diagnosis to transplant, year of transplant or conditioning regimen. Our data suggest that HDT followed by autologous HCT for relapsed WT is well tolerated and outcomes are similar to those reported in the literature. As attempts to conduct a randomized trial comparing maintenance chemotherapy with consolidation versus HDT followed by stem cell transplant have failed, one should balance the potential benefits with the yet unknown long-term risks. As disease recurrence continues to be the most common cause of death, future research should focus on the development of consolidation therapies for those patients achieving complete response to therapy

Using Surrogate Road Network for Map-Matching: A Sensitivity Analysis of Positional Accuracy

International audienc

SPH simulation of green water and ship flooding scenarios

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Discordance of peripheral artery disease diagnosis using exercise transcutaneous oxygen pressure measurement and post-exercise ankle-brachial index

International audienceIn patients with exertional limb symptoms and normal ankle-brachial index (ABI) at rest, exercise testing can be used to diagnose lower extremity arterial disease (LEAD). Post-exercise ABI decrease or Exercise transcutaneous oxygen pressure measurement (Exercise-TcPO2) can be used to diagnose LEAD. Objectives were (i) to assess the agreement between both methods (ii) to define the variables associated with the discordance, and (iii) to present results of healthy subjects. In this prospective cross-sectional study, patients with exertional limb symptoms and normal rest ABI were consecutively included. ABI was measured at rest and after standardized exercise protocol as well as Exercise-TcPO2. A kappa coefficient with a 95% confidence interval was used to assess the agreement between the two methods. Logistic regression analysis was performed to outline variables potentially responsible for discordance. Ninety-six patients were included. The agreement between the tests was weak with a k value of 0.23 [0.04-0.41]. Logistic regression analysis found that a medical history of lower extremity arterial stenting (odds ratio 5.85[1.68-20.44]) and age (odds ratio 1.06[1.01-1.11]) were the main cause of discordance. This study suggests that post-exercise ABI and Exercise-TcPO2 cannot be used interchangeably for the diagnosis of LEAD in patients with exertional symptoms and normal rest ABI