HESS J1632-478: an energetic relic

HESS J1632-478 is an extended and still unidentified TeV source in the galactic plane. In order to identify the source of the very high energy emission and to constrain its spectral energy distribution, we used a deep observation of the field obtained with XMM-Newton together with data from Molonglo, Spitzer and Fermi to detect counterparts at other wavelengths. The flux density emitted by HESS J1632-478 peaks at very high energies and is more than 20 times weaker at all other wavelengths probed. The source spectrum features two large prominent bumps with the synchrotron emission peaking in the ultraviolet and the external inverse Compton emission peaking in the TeV. HESS J1632-478 is an energetic pulsar wind nebula with an age of the order of 10^4 years. Its bolometric (mostly GeV-TeV) luminosity reaches 10% of the current pulsar spin down power. The synchrotron nebula has a size of 1 pc and contains an unresolved point-like X-ray source, probably the pulsar with its wind termination shock.Comment: A&A accepted, 9 pages, 5 figures, 4 table

Virtual anthropology: a preliminary test of macroscopic observation versus 3D surface scans and computed tomography (CT) scans.

Virtual anthropology (VA) is based on applying anthropological methods currently used to analyse bones to 3D models of human remains. While great advances have been made in this endeavour in the past decade, several interrogations concerning how reliable these models are and what their proper use should be remain unanswered. In this research, a fundamental assumption of VA has been investigated: if the way we perceive and apply an anthropological method is truly similar when looking at bones macroscopically and through various 3D media. In order to answer, 10 skulls of known age and sex were scanned using a computed tomography (CT) scanner and a 3D surface scanner. Two observers separately applied a defined staging method to eight suture sites on these skulls, first looking at the bone macroscopically, then at the 3D surface scan, and finally on the CT scan. Two rounds of observation were carried out by each observer. Intra- and inter-observer error were evaluated, and two sample t-tests used to evaluate if the different types of medium used yielded significantly different observations. The results show a high degree of inter-observer error, and that data obtained from 3D surface scans differ from macroscopic observation (confidence level 95%, P ≤ 0.05). CT scans, in these settings, yielded results comparable to those obtained through macroscopic observations. These results offer many possibilities for future research, including indications on the kind of anthropological methods and anatomical landmarks that might be reliably transferable to the virtual environment. All current methods used in traditional anthropology should be tested, and if they prove unreliable, new techniques to analyse bones from virtual models should be developed.Key pointsLarge discrepancies between observation on dry bones and computer-generated 3D models (surface scans or CT scans) could lead to the re-evaluation of the suitability of traditional anthropological methods for application on 3D models.This preliminary study evaluates whether macroscopic, 3D surface scans, and CT scans viewings generate different observations.The results indicate that the data are not always coherent across all three media of observation.Explanations include the aspect given to the bone by the 3D software, differences between handling bones in real life versus on a computer, and level of expertise of the observers

HESS J1632-478: An energetic relic

HESS J1632-478 is an extended and still unidentified TeV source in the galactic plane. In order to identify the source of the very high energy emission and to constrain its spectral energy distribution, we used a deep observation of the field obtained with XMM-Newton together with data from Molonglo, Spitzer and Fermi to detect counterparts at other wavelengths. The spectral energy density features two large prominent bumps with the synchrotron emission peaking in the ultraviolet and the external inverse Compton emission peaking in the TeV. HESS J1632-478 is an energetic pulsar wind nebula with an age of the order of 104 years. Its bolometric (mostly GeV-TeV) luminosity reaches 10% of the current pulsar spin down power. The synchrotron nebula has a size of 1 pc and contains an unresolved point-like X-ray source, probably the pulsar with its wind termination shock

Mirror Position Determination for the Alignment of Cherenkov Telescopes

Imaging Atmospheric Cherenkov Telescopes (IACTs) need imaging optics with large apertures to map the faint Cherenkov light emitted in extensive air showers onto their image sensors. Segmented reflectors fulfill these needs using mass produced and light weight mirror facets. However, as the overall image is the sum of the individual mirror facet images, alignment is important. Here we present a method to determine the mirror facet positions on a segmented reflector in a very direct way. Our method reconstructs the mirror facet positions from photographs and a laser distance meter measurement which goes from the center of the image sensor plane to the center of each mirror facet. We use our method to both align the mirror facet positions and to feed the measured positions into our IACT simulation. We demonstrate our implementation on the 4 m First Geiger-mode Avalanche Cherenkov Telescope (FACT).Comment: 11 figures, small ray tracing performance simulation, and implementation demonstratio

FACT - Monitoring Blazars at Very High Energies

The First G-APD Cherenkov Telescope (FACT) was built on the Canary Island of La Palma in October 2011 as a proof of principle for silicon based photosensors in Cherenkov Astronomy. The scientific goal of the project is to study the variability of active galatic nuclei (AGN) at TeV energies. Observing a small sample of TeV blazars whenever possible, an unbiased data sample is collected. This allows to study the variability of the selected objects on timescales from hours to years. Results from the first three years of monitoring will be presented. To provide quick flare alerts to the community and trigger multi-wavelength observations, a quick look analysis has been installed on-site providing results publicly online within the same night. In summer 2014, several flare alerts were issued. Results of the quick look analysis are summarized.Comment: 2014 Fermi Symposium proceedings - eConf C14102.

Data compression for the First G-APD Cherenkov Telescope

The First Geiger-mode Avalanche photodiode (G-APD) Cherenkov Telescope (FACT) has been operating on the Canary island of La Palma since October 2011. Operations were automated so that the system can be operated remotely. Manual interaction is required only when the observation schedule is modified due to weather conditions or in case of unexpected events such as a mechanical failure. Automatic operations enabled high data taking efficiency, which resulted in up to two terabytes of FITS files being recorded nightly and transferred from La Palma to the FACT archive at ISDC in Switzerland. Since long term storage of hundreds of terabytes of observations data is costly, data compression is mandatory. This paper discusses the design choices that were made to increase the compression ratio and speed of writing of the data with respect to existing compression algorithms. Following a more detailed motivation, the FACT compression algorithm along with the associated I/O layer is discussed. Eventually, the performances of the algorithm is compared to other approaches.Comment: 17 pages, accepted to Astronomy and Computing special issue on astronomical file format

Nanoscale battery cathode materials induce DNA damage in bacteria

The increasing use of nanoscale lithium nickel manganese cobalt oxide (LixNiyMnzCo1−y−zO2, NMC) as a cathode material in lithium-ion batteries poses risk to the environment. Learning toxicity mechanisms on molecular levels is critical to promote proactive risk assessment of these complex nanomaterials and inform their sustainable development. We focused on DNA damage as a toxicity mechanism and profiled in depth chemical and biological changes linked to DNA damage in two environmentally relevant bacteria upon nano-NMC exposure. DNA damage occurred in both bacteria, characterized by double-strand breakage and increased levels of many putative chemical modifications on bacterial DNA bases related to direct oxidative stress and lipid peroxidation, measured by cutting-edge DNA adductomic techniques. Chemical probes indicated elevated intracellular reactive oxygen species and transition metal ions, in agreement with DNA adductomics and gene expression analysis. By integrating multi-dimensional datasets from chemical and biological measurements, we present rich mechanistic insights on nano-NMC-induced DNA damage in bacteria, providing targets for biomarkers in the risk assessment of reactive materials that may be extrapolated to other nano–bio interactions

Multiple sclerosis disease: A computational approach for investigating its drug interactions

Multiple Sclerosis (MS) is a chronic and potentially highly disabling disease that can cause permanent damage and deterioration of the central nervous system. In Europe it is the leading cause of non-traumatic disabilities in young adults, since more than 700,000 EU people suffer from MS. Although recent studies on MS pathophysiology have been performed, providing interesting results, MS remains a challenging disease. In this context, thanks to recent advances in software and hardware technologies, computational models and computer simulations are becoming appealing research tools to support scientists in the study of such disease. Motivated by this consideration, we propose in this paper a new model to study the evolution of MS in silico, and the effects of the administration of the daclizumab drug, taking into account also spatiality and temporality of the involved phenomena. Moreover, we show how the intrinsic symmetries of the model we have developed can be exploited to drastically reduce the complexity of its analysis

Elovl5 is required for proper action potential conduction along peripheral myelinated fibers

Elovl5 elongates fatty acids with 18 carbon atoms and in cooperation with other enzymes guarantees the normal levels of very long‐chain fatty acids, which are necessary for a proper membrane structure. Action potential conduction along myelinated axons depends on structural integrity of myelin, which is maintained by a correct amount of fatty acids and a proper interaction between fatty acids and myelin proteins. We hypothesized that in Elovl5 (−/−) mice, the lack of elongation of Elovl5 substrates might cause alterations of myelin structure. The analysis of myelin ultrastructure showed an enlarged periodicity with reduced G‐ratio across all axonal diameters. We hypothesized that the structural alteration of myelin might affect the conduction of action potentials. The sciatic nerve conduction velocity was significantly reduced without change in the amplitude of the nerve compound potential, suggesting a myelin defect without a concomitant axonal degeneration. Since Elovl5 is important in attaining normal amounts of polyunsaturated fatty acids, which are the principal component of myelin, we performed a lipidomic analysis of peripheral nerves of Elovl5‐deficient mice. The results revealed an unbalance, with reduction of fatty acids longer than 18 carbon atoms relative to shorter ones. In addition, the ratio of saturated to unsaturated fatty acids was strongly increased. These findings point out the essential role of Elovl5 in the peripheral nervous system in supporting the normal structure of myelin, which is the key element for a proper conduction of electrical signals along myelinated nerves