69 research outputs found
Correlated Markov Quantum Walks
We consider the discrete time unitary dynamics given by a quantum walk on
performed by a particle with internal degree of freedom, called coin
state, according to the following iterated rule: a unitary update of the coin
state takes place, followed by a shift on the lattice, conditioned on the coin
state of the particle. We study the large time behavior of the quantum
mechanical probability distribution of the position observable in for
random updates of the coin states of the following form. The random sequences
of unitary updates are given by a site dependent function of a Markov chain in
time, with the following properties: on each site, they share the same
stationnary Markovian distribution and, for each fixed time, they form a
deterministic periodic pattern on the lattice.
We prove a Feynman-Kac formula to express the characteristic function of the
averaged distribution over the randomness at time in terms of the nth power
of an operator . By analyzing the spectrum of , we show that this
distribution posesses a drift proportional to the time and its centered
counterpart displays a diffusive behavior with a diffusion matrix we compute.
Moderate and large deviations principles are also proven to hold for the
averaged distribution and the limit of the suitably rescaled corresponding
characteristic function is shown to satisfy a diffusion equation.
An example of random updates for which the analysis of the distribution can
be performed without averaging is worked out. The random distribution displays
a deterministic drift proportional to time and its centered counterpart gives
rise to a random diffusion matrix whose law we compute. We complete the picture
by presenting an uncorrelated example.Comment: 37 pages. arXiv admin note: substantial text overlap with
arXiv:1010.400
Random Time-Dependent Quantum Walks
We consider the discrete time unitary dynamics given by a quantum walk on the
lattice performed by a quantum particle with internal degree of freedom,
called coin state, according to the following iterated rule: a unitary update
of the coin state takes place, followed by a shift on the lattice, conditioned
on the coin state of the particle. We study the large time behavior of the
quantum mechanical probability distribution of the position observable in
when the sequence of unitary updates is given by an i.i.d. sequence of
random matrices. When averaged over the randomness, this distribution is shown
to display a drift proportional to the time and its centered counterpart is
shown to display a diffusive behavior with a diffusion matrix we compute. A
moderate deviation principle is also proven to hold for the averaged
distribution and the limit of the suitably rescaled corresponding
characteristic function is shown to satisfy a diffusion equation. A
generalization to unitary updates distributed according to a Markov process is
also provided. An example of i.i.d. random updates for which the analysis of
the distribution can be performed without averaging is worked out. The
distribution also displays a deterministic drift proportional to time and its
centered counterpart gives rise to a random diffusion matrix whose law we
compute. A large deviation principle is shown to hold for this example. We
finally show that, in general, the expectation of the random diffusion matrix
equals the diffusion matrix of the averaged distribution.Comment: Typos and minor errors corrected. To appear In Communications in
Mathematical Physic
The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease.
The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of their roles in global and local Ca2+ homeostasis and intracellular Ca2+ signaling in a wide variety of cell types and tissues. It is becoming clear that the spatiotemporal patterns of expression of the PMCAs and the fact that their abundances and relative expression levels vary from cell type to cell type both reflect and impact on their specific functions in these cells. Over recent years it has become increasingly apparent that these genes have potentially significant roles in human health and disease, with PMCAs1-4 being associated with cardiovascular diseases, deafness, autism, ataxia, adenoma, and malarial resistance. This review will bring together evidence of the variety of tissue-specific functions of PMCAs and will highlight the roles these genes play in regulating normal physiological functions and the considerable impact the genes have on human disease
Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population: a nationwide observational, cross-sectional study
The detection of antinuclear autoantibody (ANA) is dependent on many factors and varies between the populations. The aim of the study was first to assess the prevalence of ANA in the Polish adult population depending on age, sex and the cutoff threshold used for the results obtained. Second, we estimated the occurrence of individual types of ANA-staining patterns. We tested 1731 patient samples using commercially available IIFA using two cutoff thresholds of 1:100 and 1:160. We found ANA in 260 participants (15.0%), but the percentage of positive results strongly depended on the cutoff level. For a cutoff threshold 1:100, the positive population was 19.5% and for the 1:160 cutoff threshold, it was 11.7%. The most prevalent ANA-staining pattern was AC-2 Dense Fine speckled (50%), followed by AC-21 Reticular/AMA (14.38%) ANA more common in women (72%); 64% of ANA-positive patients were over 50 years of age. ANA prevalence in the Polish population is at a level observed in other highly developed countries and is more prevalent in women and elderly individuals. To reduce the number of positive results released, we suggest that Polish laboratories should set 1:160 as the cutoff threshold
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