Forme atypique d’une maladie de Lyme

La maladie de Lyme est une zoonose qui se manifeste essentiellement par des signes cutanés, articulaires, neurologiques et cardiaques. Elle peut exceptionnellement mimer une dermatomyosite. Nous rapportons l'observation d'une patiente âgée de 37 ans qui a présenté des myalgies et un érythroedème de la face et en péri-orbitaire. Une dermatomyosite a été fortement suspectée devant une élévation des enzymes musculaires. Elle a été traitée par une corticothérapie à forte dose. L'évolution a été marquée par l'aggravation des myalgies et l'apparition d'un déficit musculaire. Elle a été alors hospitalisée dans notre service. Les enzymes musculaires étaient élevées. L'électromyogramme était sans anomalies. Le bilan immunologique était négatif. Une enquête infectieuse a été réalisée retrouvant une sérologie de Lyme positive. Après administration d'une antibiothérapie adaptée, l'évolution était bonne avec disparition du tableau clinico-biologique de dermatomyosite. La précocité du diagnostic et l'instauration d'un traitement efficace permet d'éviter des complications graves

SYNTHESIS, IN VITRO ANTIMICROBIAL, ANTI-LIVER CANCER EVALUATION OF SOME NOVEL BIS-CYANOACRYLAMIDE AND BIS-AZOLES DERIVATIVES

Objective: Synthesis of some novel bis [3-(aryl)-2-cyanoacrylamide], bis-pyrazole, bis-thiazole and bis-triazole derivatives starting from N,N'-ethane-1,2-diylbis(2-cyanoacetamide) (1) to evaluate for their in-vitro antibacterial, antifungal and anticancer activities.Methods: Reaction of N, N'-ethane-1,2-diylbis(2-cyanoacetamide) (1) with different aromatic and heteroaromatic aldehydes yielded the corresponding bis[3-(aryl)-2-cyanoacrylamide] derivatives, which reacted with hydrazine hydrate to give N,N'-ethane-1,2-diylbis[3-amino-5-(4-aryl)-1H-pyrazole-4-carboxamide] derivatives. Compound 1 reacted with each of thioglycolic acid, Phenyl isocyanate and elemental sulfur in presence triethylamine to give bis-thiazole derivatives. Diazotization of 1 with the desired diazonium chloride yielded the bis-hydrazone derivatives. The latter compounds refluxed with hydroxylamine hydrochloride and chloro- acetonitrile to give bis-triazole and bis-pyrazole derivatives respectively.Results: The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1H NMR, [13]C NMR and mass spectral data. A total fourteen new synthesized compounds were evaluated for their in-vitro antibacterial, antifungal and anticancer activities against human liver cancer cell line (HEPG-2).Conclusion: The results obtained indicated that some of such compounds showed promising activities against Gram-positive, Gram-negative bacteria, fungi and anticancer activity in relation to the reference drugs ampicillin, gentamicin, Amphotericin B and vinblastine respectively.Â

Difficulté diagnostique d’une tuberculose laryngée isolée chez une femme diabétique

La tuberculose laryngée isolée est rare. Elle peut mimer une tumeur maligne retardant le diagnostic et aggravant le pronostic. Le terrain diabétique favorise la survenue des infections notamment la tuberculose dans sa forme sévère. Nous rapportons l'observation d'une patiente diabétique de type 2, âgée de 51 ans, hospitalisée pour une fièvre prolongée, une dysphonie et un diabète déséquilibré. Les hémocultures étaient négatives. L'examen laryngoscopique a confirmé un aspect érythémateux et épais des deux cordes, une lésion ulcérée peu profonde de l'hémilarynx gauche et une végétation érythémateuse de 5 mm de diamètre. L'examen histologique a révélé des granulomes épithéloïodes et giganto-cellulaires avec une nécrose caséeuse évocateurs de la tuberculose. La culture sur milieu de lobstein de tissus biopsiés à partir des cordes vocales a été positive. Aucun autre foyer tuberculeux n'a été retrouvé. Le traitement par une combinaison de l'isoniazide, la rifampicine, l'éthambutol, la pyrazinamide a permis une résolution de symptôme

Marginal bone loss around platform-switched and platform-matched implants following immediate dental implant placement – Systematic Review

Objective This study aimed to examine marginal bone loss (MBL) around immediately placed platform-switched implants (PS) compared to platform-matched (PM) implants; and to critically appraise the available literature on this topic. Materials and Methods Randomized control trials (RCTs), non- randomized control trials (NRCT) and case series of immediate placement platform-switched and platform-matched implant, published in English were included in the study. Two databases, namely Medline and PubMed covering the period between July 1966 and July 2023 were searched. A total of five case series, five RCTs and one NRCT were included in this systematic review by using pre-defined study selection criteria and following the PRISMA protocol. A critical appraisal of the selected studies was completed using standardized appraisal checklists, including CASP tool for critical appraisal of RCTs, the Downs and Black checklist for NRCT, and the CEBMa checklist for case series studies. Results Five studies showed a statistically significant difference in MBL (PS: 0.18–0.78 mm, PM 0.51–1.19 mm). The studies featured a small sample size, and substantial methodological variability in patients’ selection criteria, implant and abutment designs, connection types and surgical protocols. A high risk of bias was identified, especially in case series studies. Conclusion The use of PS implants in immediate placement protocols can lead to a statistically significant reduction in MBL compared to PM implants. However, the results need to be interpreted with caution, given the numerous confounding variables and clinical heterogeneity existing between the studies

Long-lived alpha emitters concentrations in the spices consumed in Iraq using CR-39 detector

البهارات تستخدم كاضافات على الطعام في مختلف البلدان ، من ضمنها بلدنا، لذا من الضروري التاكد من خلوها من المواد المشعة الضارة بصحة الانسان. هدف هذا البحث كان قياس تراكيز باعثات الفا ، وقياس الجرعة السنوية الفعالة  AED الناتجة من تناول الرادون. استخدم كاشف  CR-39 في قياس تراكيز الرادون ، الراديوم واليورانيوم في 24 عينة من البهارات المختارة من الاسواق. تراكيز الرادون وجد في هذا البحث تتغير من 65.102 الى 195.30 Bq/m3 وبقيمة متوسطة 126.47 Bq/m3 وهذه القيمة هي اعلى بقليل من  100 Bq/m3 المستوى او الحدود المقبولة من منظمة الصحة العالمية (WHO) واقل من 200 Bq/m3 التي هي حدود اللوائح البريطانية للوقاية من الاشعاع (NRPB) والاوربية. الجرعة السنوية الفعالة للرادون تراوحت بين 1.642- 4.927 mSv/y التي هي ضمن المدى 0.2 - 10 mSv/y  للجنة الامم المتحدة لاثار الاشعاع الذري (UNSCEAR). تراكيز الراديوم تغيرت بين 0.446 - 1.367 Bq/Kg بمتوسط 0.943 Bq/Kg. وتراكيز فعالية اليورانيوم كانت في المدى 4.408 - 13.520 Bq/Kg وبقيمة متوسطة 9.322 Bq/Kg. هذا العمل قاس التراكيز المحددة للمواد المشعة الموجودة في البهارات وبين ان هذه البهارات امنة للتناول.Spices are mainly used as additives to diets in different countries, including our country, so it is necessary to ensure that they are free of radioactive substances harmful to human health. This research aimed to measure the concentrations of alpha emitters, and measure the annual effective dose AED resulting from the intake of radon. The CR-39 detector used to measure radon, radium, and uranium concentrations in the 24 spices samples selected from markets. In this work the radon concentrations in the samples were found to vary from  65.102 to 195.30 Bq/m3 with 126.47 Bq/m3 a mean value, this mean value is a small amount over 100 Bq/m3 the reference level limits of the World Health Organization (WHO), below 200 Bq/m3 of the UK Board of National Radiation Protection (NRPB) limits and below the level of the European Recommendation Commission. The annual radon effective dose varied between 1.642-4.927 mSv/y which is within the range of 0.2-10 mSv/y of (UNSCEAR). Radium contents vary between 0.446-1.367 Bq/Kg with 0.943 Bq/Kg as a mean value. The range of uranium activity concentrations is between 4.408-13.520 Bq/Kg with a mean value of 9.322 Bq/Kg. This work identified and measured the specified concentrations of radionuclide present in spices showed that spices are safe for consumption

The Pattern of Histologically-Proven Acute Post-infectious Glomerulonephritis in Tunisian Adults Seen in 1976 - 2004

Introduction: Acute post-infectious glomerulonephritis (APIGN) is uncommon in adults. It is widely recognized that the prognosis of APIGN is good in children. There is however little information about its long-term prognosis in adults.Methods: Between December 1976 and October 2004, 148 adult cases of APIGN were managed in our center. We retrospectively reviewed these patients’ records and evaluated their clinical course and outcome.Results: The mean age of studied patients was 36±15 years, and the male to female ratio was 2.3. The most common site of preceding infection was the respiratory tract (68.8%). At presentation, 89.2% had nephritic syndrome and 9.4% had rapidly progressive glomerulonephritis.Proteinuria was observed in 99.3%, hematuria in 95.3%, peripheral edema in 89.2% and hypertension in 81.8%. Most patients (60.7%) had acute kidney injury and four patients (2.7%) required dialysis. Renal biopsy showed diffuse endocapillary proliferative glomerulonephritis in 88.8% of patients, associated with extracapillary proliferation in 12%. After a median follow-up of 2.5 year, only two patients died and 16.12% of patients hadpersistent clinical and/or biological abnormality. Chronic kidney disease was noted in 10 patients (6.75%) including four patients (2.7%) who progressed to end-stage renal disease. Poor prognostic factors included nephrotic range proteinuria, extracapillary proliferation in renal biopsy,acute kidney injury and the need for dialysis.Conclusion: In this cohort of patients, APIGN progressed to chronic kidney disease in less than 10% of patients

Brown adipose tissue and regulation of human body weight

Background: Approximately 30% of the global population is affected by obesity. Traditional non-surgical measures for weight loss have limited efficacy and tolerability. Therefore, there is a need for novel, effective therapies. Brown adipose tissue (BAT) has been implicated in physiological energy expenditure, indicating that it could be targeted to achieve weight loss in humans. The use of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography—computed tomography—(PET-CT) imaging has enabled the discovery of functionally active BAT in the supraclavicular, subclavian, and thoracic spine regions of human adults. This review aims to discuss the reasons behind the renewed interest in BAT, assess whether it is metabolically important in humans, and evaluate its feasibility as a therapeutic target for treating obesity. Sources of material: PubMed Central, Europe PMC, Medline. Findings: In vivo studies have shown that BAT activity is regulated by thyroid hormones and the sympathetic nervous system. Furthermore, BAT uniquely contains uncoupling protein 1 (UCP1) that is largely responsible for non-shivering thermogenesis. Cold exposure can increase BAT recruitment through the browning of white adipose tissue (WAT); however, this technique has practical limitations that may preclude its use. Currently available medicines for humans, such as the β3-adrenergic receptor agonist mirabegron or the farnesoid X receptor agonist obeticholic acid, have generated excitement, although adverse effects are a concern. Capsinoids represent a tolerable alternative, which require further investigation. Conclusions: The use of currently available BAT-activating agents alone is unlikely to achieve significant weight loss in humans. A combination of BAT activation with physical exercise and modern, successful dietary strategies represents a more realistic option

Diagnosis Using an Estimation Method for Partially Observed Petri Net

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