1,111 research outputs found
Audiovisual semantic congruency effect with onomatopoeia
It has been reported that when a congruent natural sound precedes briefly presented visual stimuli, it promotes performance in psychophysics detection tasks. Onomatopoeias refer to words that phonetically mimic or suggest actual sounds. Onomatopoeic words are a form of sound symbolism and are frequently used in Japanese language. In this study, we examined whether the presentation of spoken Japanese onomatopoeia to Japanese native-speakers results in visual detection sensitivity changes. Results indicate that when onomatopoeias are presented 227 ms before a visual stimulus, they have a modulatory audiovisual effect. This effect is closer to the results observed with natural sounds than spoken words, with d’ being lower for onomatopoeias when compared with natural sounds. Such suggests that Japanese spoken onomatopoeias may be processed in a manner that is closer to natural sounds than spoken words and points to behavioral consequences of sound symbolism
Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts
A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been synthesized. The key step involved a totally stereocontrolled C-Michael addition of a serine-equivalent C-nucleophile to tri-O-benzyl-2-nitro-D-galactal, previously published by the authors. Stereoselective transformations of the Michael adduct allowed us the synthesis of compounds with mono- or diantennated aglycone moieties and different topologies. In vitro screening showed highly selective inhibition of bovine liver β-glucosidase/β-galactosidase and specific inhibition of human β-glucocerebrosidase among lysosomal glycosidases for compounds bearing palmitoyl chains in the aglycone, with a marked dependence of the inhibition potency upon their number and location. Molecular dynamics simulations highlighted the paramount importance of an optimal orientation of the hydrophobic substituent to warrant efficient non-glycone interactions, which are critical for the binding affinity. The results provide a rationale for the strong decrease of the inhibition potency of APP compounds on going from neutral to acidic pH. The best candidate was found to behave as pharmacological chaperone in Gaucher fibroblasts with homozygous N370S and F213I mutations, with enzyme activity enhancements similar to those encountered for the reference compound AmbroxolMinisterio de Economía y Competitividad CTQ2012-36365, SAF2013-44021-RJunta de Andalucía FQM-1467European Union Seventh Framework Programme FP7-People-2012-CI
Geosynthetic sorption sheet --Another function of geosynthetics?
This paper discusses a novel geosynthetics sorption sheet that provides both sorption and traditional geosynthetic functions. In particular, the geosynthetic sorption sheet facilitates both water drainage and chemical barrier function. In this paper, batch sorption tests are used to evaluate the sheet's attenuation performance. The results of soil tank tests involving a 110 x 80 x 12 cm tank are also discussed. A key finding was the higher sorbed extent of arsenate compared with arsenite. The sheet absorbed more than 80% of the arsenic when it was contacted for 15 minutes with 0.1 mg/L of arsenate. Based on the soil tank test, ground particles surrounding the sheet are more important to seepage water distribution than the sheet itself
Pressure sensor based on freely suspended ferroelectric liquid crystal film
This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in S. V. Yablonskii, K. Nakano, A. S. Mikhailov, M. Ozaki, and K. Yoshino, Appl. Phys. Lett. 80, 571 (2002) and may be found at https://doi.org/10.1063/1.1430270
Lipid profile disturbances are highly prevalent in Japanese-Brazilians
Alta prevalência de diabetes em população nipo-brasileira de Bauru/SP foi previamente relatada. Visando a complementar a avaliação do risco cardiometabólico, este estudo analisou distúrbios no perfil lipídico de 1.330 nipo-brasileiros (46% homens) > 30 anos. Definiu-se hipercolesterolemia por níveis de colesterol total > 240 mg/dL; hipertrigliceridemia por valores > 150 mg/dL e HDL-colesterol baixo por valores < 40 mg/dL e < 50 mg/dL para homens e mulheres, respectivamente. A prevalência desses distúrbios foi comparada pelo qui-quadrado, estratificando-se por sexos e categorias glicêmicas. As médias dos lipídeos e lipoproteínas foram comparadas entre sexos pelo teste t de Student. A prevalência de hipertrigliceridemia foi de 66,0% (IC95%:63,5 - 68,5%), sendo mais comum em homens e aumentando com a piora da categoria glicêmica; a trigliceridemia média foi 235,7 ± 196,3 mg/dL. A prevalência de hipercolesterolemia foi 24,4% (IC95%:22,1 - 26,7%); HDL-C baixo foi observado em 43,0% (IC95%:39,4 - 46,6%] das mulheres e 17,5% (IC95%:14,5 - 20,5%) dos homens, porém a razão colesterol total/HDL-C foi menor em mulheres (4,23 ± 0,68 vs. 4,40 ± 0,73; p < 0,001). Em nipo-brasileiros, a hipertrigliceridemia é a anormalidade lipídica mais comum, em concordância com a elevada prevalência de diabetes. Os homens apresentaram pior perfil lipídico que as mulheres. Sugere-se que hábitos de vida ocidental possam estar deteriorando a saúde desses indivíduos.High prevalence of diabetes has been previously reported in Japanese-Brazilians. In an attempt to better estimate the cardiometabolic risk, this study evaluated lipid disorders in 1,330 Japanese-Brazilians (46% men) aged >30 years. Hypercholesterolemia was defined as serum cholesterol > 240 mg/dL, hypertriglyceridemia as values > 150 mg/dL and low-HDL-C as values <40 mg/dL and <50 mg/dl for men and women respectively. The prevalence of dyslipidemias was compared by the chi-square test between gender and glycemic category. Mean and Standard Deviation of lipids and lipoproteins were compared by the Student t-Test between gender. Hypertriglyceridemia was detected in 66.0% [95% CI: 63.5-68.5] of the population, being more common in men and increasing with deterioration of glucose metabolism. Mean level of triglycerides was 235.7±196.3 mg/dL. The prevalence of hypercholesterolemia was 24.4% [95% CI: 22.1- 26.7]. Low HDL-C was observed in 17.5% [95% CI: 14.5-20.5] of men and 43.0% [95% CI: 39.4- 46.6] of women but total / HDL-cholesterol ratio was lower in women (4.23 ± 0.68 vs. 4.40 ± 0.73, p<0.001). In Japanese-Brazilians, hypertriglyceridemia is the commonest dyslipidemia, in agreement with the high prevalence of diabetes. Men showed a worse lipid profile than women; it was suggested that the Western diet and living habits could be deteriorating their health.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP
Crystalline ground state in chiral Gross-Neveu and Cooper pair models at finite densities
We study the possibility of spatially non-uniform ground state in
(1+1)-dimensional models with quartic fermi interactions at finite fermion
densities by introducing chemical potential \mu. We examine the chiral
Gross-Neveu model and the Cooper pair model as toy models of the chiral
symmetry breaking and the difermion pair condensates which are presumed to
exist in QCD. We confirm in the chiral Gross-Neveu model that the ground state
has a crystalline structure in which the chiral condensate oscillates in space
with wave number 2\mu. Whereas in the Cooper pair model we find that the vacuum
structure is spatially uniform. Some discussions are given to explain this
difference.Comment: 18 pages, REVTeX, 3 eps figure
Photonics of fullerene-conducting polymer composites and multilayered structures: new results and prospects
SPIE's 1995 International Symposium on Optical Science, Engineering, and Instrumentation, 1995, San Diego, CA, United StatesKatsumi Yoshino, Kenji Yoshimoto, Kazuya Tada, Hishashi Araki, Tsuyoshi Kawai, Masanori Ozaki, and Anvar A. Zakhidov "Photonics of fullerene-conducting polymer composites and multilayered structures: new results and prospects", Proc. SPIE 2530, Fullerenes and Photonics II, (8 December 1995). DOI: https://doi.org/10.1117/12.22812
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