A study on the defluoridation in water by using natural soil

Removal of excess fluoride (F−) from the water has been attempted by several authors by using different materials both natural and artificial. The main aim of this paper was to attempt the fluoride removal by using the locally available red soil adopting column method. The red soil was mixed in different proportion with sand in order to increase the porosity and permeability property of the medium. It was optimized for 4:1 ratio of red soil to sand and it was used for the following experiment. The experiment was conducted in 11 batches for a period of about 9,213 min. Fresh standard solution of F was used in each batch, prepared from Orion 1,000 ppm solution. The samples were collected and analyzed for pH, EC (Electrical Conductivity) and HCO3. Rate of flow of water and efficiency of adsorption were calculated and compared with the fluoride removal capacities of the medium. The medium used for the fluoride removal was subjected to FTIR analysis before and after the experiment. The variation of IR spectrum before and after treatment signifies the changes in the OH bonding between Al and Fe ions present in the soil. The variation in pH decreased during the course of defluoridation. Higher F removal was noted when flow rate was lesser. An attempt on the regeneration of the fluoride adsorbed soil was also made and found to be effective

Agility, innovation and impact: pedestrian safety walkway intervention in Kajang, Malaysia

Child pedestrian as a vulnerable group around the school area needs intervention to address their problem as their risk is high for sharing the roadway with vehicles. The problem here was high traffic volume with speed enough to be dangerous for children who are exposed in the open. Thus to reduce the child pedestrian risk on road, a pedestrian safety walkway intervention was mooted and grant proposals were bidded and successfully obtained from donors. This resulted in the birth of a Pedestrian Safety Walkway with the aim of segregating the pedestrian from the vehicles whom are using the same roadway

Risk factors of musculoskeletal disorders (MSD) among palm oil mill workers

The palm oil industry is the fourth largest contributor to the Malaysian Gross National Income (GNI) but the importance of this industry to the nation’s economy does not preclude them from the risk of being affected by the occurrence of musculoskeletal disorders (MSD) among the workers in palm oil mills. Previous studies carried out have not properly explained the exact reasons for the occurrence of musculoskeletal disorders (MSD) among the palm oil mill workers. Thus, this study aim to determine the association between risk factors and MSD among palm oil mill workers. A total of 120 male workers were consecutively enrolled in this crosssectional study. Information on sociodemographic, working, lifestyle, health and injury factors were collected via questionnaire and face-to-face interviews. A high lifetime prevalence of MSD (71.7 percent) among palm oil mill workers was found. However, the one-year prevalence of MSD among the same population was only 50.8 percent. Logistic regression analysis adjusted for age, Body Mass Index (BMI) and smoking revealed that the risk factors: history of previous injury [2.35, 95 percent CI 1.12-4.93], Osteoarthritis [3.9, 95 percent CI 1.568-9.708] and perception of exertion [8.09, 95 percent CI 1.358-48.170] was found to be significantly associated with MSD symptoms reported in the past 12 months. As a conclusion, exposure to the combination of these risk factors may lead to an increased risk of developing MSD among palm oil mill workers

Children pillion rider safety awareness among motorcycle users in Malaysia

Motorcycle is one of the more popular modes of transport for Malaysian people due to its low price and easy usability. This paper reviews the current safety initiatives undertaken to address the need to enhance children safety whilst riding as pillion on motorcycles and suggest possible remedial action to counter the possible lack of awareness for child pillion riders. A search was undertaken of all the major database of articles. Articles related to children’s safety systems, children related injuries, children related accident data, available laws and legislation were reviewed. There is a greater need for the stricter enforcement of safety laws in Malaysia due to the fact that the accident statistics show a large percentage of motorcycle accidents involve pillion riding children. However, enforcement of laws in developing countries is not easy and one has to start at the root of the problem, i.e. the parents and adults who ride these children as pillion on motorcycles. This paper highlights the need for new safety initiatives and programmes to be undertaken by the government, law agencies and non-governmental organisations for parents and adults to understand the importance of their children safety while riding on motorcycles. Engineering countermeasures and intervention are needed to protect these vulnerable users. Besides the helmet, a device capable of providing some sort of protection to the child whilst riding pillion should be designed and developed

Health care workers safety: screening and immunization: a review

The paper puts forth the need for health care workers safety whilst undertaking their job on a daily basis. Presently there are number of factors that are directly linked to the safety of health care workers. However, Occupational Health is very important and useful for health workers that are exposed to their job hazards. Every year, many lives are lost because of the spread of infections in hospitals. Every hospital’s occupational health departments should ensure that all new staff are vaccinated to protect them against microorganisms carried by other patients, and with vaccinated against preventable diseases. This will help to prevent the health workers from occupational exposure to patients’ blood or any other bodily substances, including injury from sharp objects, and also guarantees that the new employees does not infect the patients with infectious diseases. Furthermore, all the new staff should be screened for blood borne pathogenic diseases

Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development

A critical barrier in the treatment of endosomal and lysosomal diseases is the lack of understanding of the in vivo functions of the putative causative genes. We addressed this by investigating a key pair of endocytic adaptor proteins, PH domain-containing endocytic trafficking adaptor 1 and 2 (PHETA1/2; also known as FAM109A/B, Ses1/2, IPIP27A/B), which interact with the protein product of OCRL, the causative gene for Lowe syndrome. Here, we conducted the first study of PHETA1/2 in vivo, utilizing the zebrafish system. We found that impairment of both zebrafish orthologs, pheta1 and pheta2, disrupted endocytosis and ciliogenesis in renal tissues. In addition, pheta1/2 mutant animals exhibited reduced jaw size and delayed chondrocyte differentiation, indicating a role in craniofacial development. Deficiency of pheta1/2 resulted in dysregulation of cathepsin K, which led to an increased abundance of type II collagen in craniofacial cartilages, a marker of immature cartilage extracellular matrix. Cathepsin K inhibition rescued the craniofacial phenotypes in the pheta1/2 double mutants. The abnormal renal and craniofacial phenotypes in the pheta1/2 mutant animals were consistent with the clinical presentation of a patient with a de novo arginine (R) to cysteine (C) variant (R6C) of PHETA1. Expressing the patient-specific variant in zebrafish exacerbated craniofacial deficits, suggesting that the R6C allele acts in a dominant-negative manner. Together, these results provide insights into the in vivo roles of PHETA1/2 and suggest that the R6C variant is contributory to the pathogenesis of disease in the patient

How safe are our children in vehicles on the road? a Malaysian perspective

As Malaysia races towards a developed nation status, children are increasingly being ferried daily in vehicles almost exclusively as the majority of the population are able to afford private transportations. This paper reviews the current safety concerns for children whilst going in vehicles on Malaysian roads and the steps undertaken to address the need to enhance children’s safety whilst going in these vehicles and suggest possible remedial action to counter the possible lack of awareness for children’s safety whilst in these vehicles. This paper focuses on children on motorcycles and private vehicles (cars, vans and multi-purpose vehicle (MPV)) and excludes other form of transport (buses, lorries) as this paper tries to put forth measures that can be undertaken by the children’s parents and guardian to better enhance the safety of their children. A search was undertaken of all the major database of articles. Articles related to children’s safety systems, children related injuries, children related accident data, available laws and legislation were reviewed to present the need for greater awareness of children’s safety while going in vehicles in Malaysia. There are currently already safety legislations, measures, steps and equipments in place in ensuring the safety of children whilst going in vehicles on Malaysian roads. However, enforcement of laws in developing countries are not easy and we have to start at the root of the problem which is the parents and adults who ferry these children in vehicles. There is a pressing need to educate parents and adults alike on the urgent undertaking of child safety whilst in vehicles. Engineering countermeasures and intervention are probably needed to protect these vulnerable users. For vehicles, a device capable of providing some sort of protection to the child whilst riding pillion should be designed and developed. A legislation mandating the use of child seats whilst ensuring the child seats are affordable to the masses

Prevalence of safety equipment and helmet use among school students commuting to school in South Selangor, Malaysia

A cross-sectional observational study was conducted on the use of helmets and other safety equipment for child pillion riders while going to a school in Sri Serdang, Selangor, Malaysia. The objective of this study was to analyze and report the proportion of children wearing helmets and other safety equipment while riding pillion on a motorcycle. The prevalence of helmet use among the students as pillion riders was low (47.88%) compared to the adults (75.21%). This was unsatisfactory. There is a distinct lack of awareness of the benefits of helmets in helping to save lives and reducing injuries. Hence, there is a need for other safety equipment to provide additional safety protection for child pillion riders to counter the lack of safety equipment use while riding pillion. The Malaysian Ministry of Transport could benefit from this study with the information gained for safety equipment use among school students

Screening for adulticidal bioactivity of South African plants against Anopheles arabiensis

<p>Abstract</p> <p>Background</p> <p>This study was conducted to evaluate whether a selection of South African ethnomedicinal plants included in this study displayed insecticidal properties when screened against adult stages of the mosquito.</p> <p>Methods</p> <p>381 crude extracts of 80 plant taxa in 42 families were sprayed onto ceramic tiles and screened using the cone bio-assay method for insecticide efficacy testing. Blood-fed, female <it>Anopheles arabiensis </it>mosquitoes were exposed to the treated tiles for a period of sixty minutes. Mosquito mortality was monitored for twenty-four hours.</p> <p>Results</p> <p>Of all the extracts analysed, the highest activity was observed in <it>Ptaeroxylon obliquum </it>(Ptaeroxylaceae) and <it>Pittosporum viridiflorum </it>(Pittosporaceae), a single extract from each, exhibiting more than 50% mortality. A large proportion (81.63%) of the extracts tested displayed low levels of mosquitocidal activity. The remainder of the extracts (17.85%) exhibited no bioactivity (0% mortality).</p> <p>Conclusions</p> <p>The screening results have shown that in accordance with WHO standards, none of the crude extracts tested had exhibited greater than 60% mortality against the adult stages of the malaria vector <it>Anopheles arabiensis</it>.</p

Defining the ligand-dependent proximatome of the sigma 1 receptor

Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerative diseases to cancer and COVID-19. S1R is ubiquitously expressed throughout the visceral organs, nervous, immune and cardiovascular systems. It is proposed to function as a ligand-dependent molecular chaperone that modulates multiple intracellular signaling pathways. The purpose of this study was to define the S1R proximatome under native conditions and upon binding to well-characterized ligands. This was accomplished by fusing the biotin ligase, Apex2, to the C terminus of S1R. Cells stably expressing S1R-Apex or a GFP-Apex control were used to map proximal proteins. Biotinylated proteins were labeled under native conditions and in a ligand dependent manner, then purified and identified using quantitative mass spectrometry. Under native conditions, S1R biotinylates over 200 novel proteins, many of which localize within the endomembrane system (endoplasmic reticulum, Golgi, secretory vesicles) and function within the secretory pathway. Under conditions of cellular exposure to either S1R agonist or antagonist, results show enrichment of proteins integral to secretion, extracellular matrix formation, and cholesterol biosynthesis. Notably, Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) displays increased binding to S1R under conditions of treatment with Haloperidol, a well-known S1R antagonist; whereas Low density lipoprotein receptor (LDLR) binds more efficiently to S1R upon treatment with (+)-Pentazocine ((+)-PTZ), a classical S1R agonist. Furthermore, we demonstrate that the ligand bound state of S1R correlates with specific changes to the cellular secretome. Our results are consistent with the postulated role of S1R as an intracellular chaperone and further suggest important and novel functionalities related to secretion and cholesterol metabolism