216 research outputs found

    Los empleos de las cenizas volantes en construcción

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    Not availableActualmente, en el mercado francés hay dos tipos de cementos que contienen cenizas volantes: los cementos puzolano metalúrgicos Fouilloux y los cementos portland con 20% de cenizas, cuya normalización está en curso

    Resonant inelastic x-ray scattering in single-crystal superconducting PrFeAsO0.7

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    Resonant inelastic x-ray scattering (RIXS) spectra at the Fe K-edge were measured for a single crystal of the iron oxypnictide superconductor PrFeAsO0.7 (Tc=42 K). They disclose a weak, broad feature centered around 4.5 eV energy loss, which is slightly resonantly enhanced when the incident energy is tuned in the vicinity of the 4p white line. We tentatively ascribe it to the charge-transfer excitation between As 4p and Fe 3d.Comment: 2 pages, 2 figure

    Performance Evaluation of HL-LHC Crab Cavity Prototypes in a CERN Vertical Test Cryostat

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    Three proof-of-principle compact crab cavity designs have been fabricated in bulk niobium and cold tested at their home labs, as a first validation step towards the High Luminosity LHC project. As a cross check, all three bare cavities have been retested at CERN, in order to cross check their performance, and cross-calibrate the CERN SRF cold test facilities. While achievable transverse deflecting voltage is the key performance indicator, secondary performance aspects derived from multiple cavity monitoring systems are also discussed. Temperature mapping profiles, quench detection, material properties, and trapped magnetic flux effects have been assessed, and the influence on performance discussed. The significant effort invested in developing expertise in preparation and testing of these crab cavities has already been fruitful for all partners, and more is to come within this ongoing program

    Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.

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    Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder resulting from a polyglutamine expansion in the huntingtin (HTT) protein. There is currently no cure for this disease, but recent studies suggest that RNAi to downregulate the expression of both normal and mutant HTT is a promising therapeutic approach. We previously developed a small hairpin RNA (shRNA), vectorized in an HIV-1-derived lentiviral vector (LV), that reduced pathology in an HD rodent model. Here, we modified this vector for preclinical development by using a tat-independent third-generation LV (pCCL) backbone and removing the original reporter genes. We demonstrate that this novel vector efficiently downregulated HTT expression in vitro in striatal neurons derived from induced pluripotent stem cells (iPSCs) of HD patients. It reduced two major pathological HD hallmarks while triggering a minimal inflammatory response, up to 6 weeks after injection, when administered by stereotaxic surgery in the striatum of an in vivo rodent HD model. Further assessment of this shRNA vector in vitro showed proper processing by the endogenous silencing machinery, and we analyzed gene expression changes to identify potential off-targets. These preclinical data suggest that this new shRNA vector fulfills primary biosafety and efficiency requirements for further development in the clinic as a cure for HD

    Itinerant effects and enhanced magnetic interactions in Bi-based multilayer cuprates

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    The cuprate high temperature superconductors exhibit a pronounced trend in which the superconducting transition temperature Tc increases with the number of CuO2 planes n in the crystal structure. We compare the magnetic excitation spectrum of Bi2+xSr2−xCuO6+δ (Bi-2201) and Bi2Sr2Ca2Cu3O10+δ (Bi-2223), with n = 1 and 3, respectively, using Cu L3-edge resonant inelastic x-ray scattering. Near the antinodal zone boundary we find the paramagnon energy in Bi-2223 is substantially higher than that in Bi-2201, indicating that multilayer cuprates host stronger effective magnetic exchange interactions, providing a possible explanation for the Tc vs n scaling. In contrast, the nodal direction exhibits very strongly damped, almost nondispersive excitations. We argue that this implies that the magnetism in the doped cuprates is partially itinerant in nature

    Investigation of the thermal stability of Mg/Co periodic multilayers for EUV applications

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    We present the results of the characterization of Mg/Co periodic multilayers and their thermal stability for the EUV range. The annealing study is performed up to a temperature of 400\degree C. Images obtained by scanning transmission electron microscopy and electron energy loss spectroscopy clearly show the good quality of the multilayer structure. The measurements of the EUV reflectivity around 25 nm (~49 eV) indicate that the reflectivity decreases when the annealing temperature increases above 300\degreeC. X-ray emission spectroscopy is performed to determine the chemical state of the Mg atoms within the Mg/Co multilayer. Nuclear magnetic resonance used to determine the chemical state of the Co atoms and scanning electron microscopy images of cross sections of the Mg/Co multilayers reveal changes in the morphology of the stack from an annealing temperature of 305\degreee;C. This explains the observed reflectivity loss.Comment: Published in Applied Physics A: Materials Science \& Processing Published at http://www.springerlink.com.chimie.gate.inist.fr/content/6v396j6m56771r61/ 21 page

    The "MINOTOR" H2020 project for ECR thruster development

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    Electric propulsion has been identified by European actors as a strategic technology for improving competitiveness in different space areas such as in-space operations and transportation. The European Commission has set up the "In-space Electrical Propulsion and Station-Keeping" Strategic Research Cluster (SRC) in the "Horizon 2020" funding framework with the goal of enabling major advances in Electric Propulsion for in-space operations and transportation. In this framework, the MINOTOR project was funded to mature a potentially disruptive cathodeless electric propulsion technology, the Electron Cyclotron Resonance (ECR) thruster. In recent years, the consortium leader ONERA has built up a large experience on ECR technology for electric propulsion, and the MINOTOR project will bring the expertise from three industrial partners (TMI, TAS-B and SAFRAN) and two university partners (UC3M and JLU) to take the next step.This work was made in the framework of project MINOTOR that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 730028
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