Education alignment

This essay reviews recent developments in embedding data management and curation skills into information technology, library and information science, and research-based postgraduate courses in various national contexts. The essay also investigates means of joining up formal education with professional development training opportunities more coherently. The potential for using professional internships as a means of improving communication and understanding between disciplines is also explored. A key aim of this essay is to identify what level of complementarity is needed across various disciplines to most effectively and efficiently support the entire data curation lifecycle

Ancient Cosmic Dust from Triassic Halite

We describe the discovery of fossil micrometeorites in ancient Triassic rock salt; the first to be found in salt and the oldest complete micrometeorites found to date. We present an estimated flux rate of micrometeorites to Earth at this time

Strange quark asymmetry in the nucleon and the NuTeV anomaly

The NuTeV anomaly of a non-universal value of the fundamental parameter sin^2\theta_W in the electroweak theory has been interpreted as an indication for new physics beyond the Standard Model. However, the observed quantity depends on a possible asymmetry in the momentum distributions of strange quarks and antiquarks in the nucleon. This asymmetry occurs naturally in a phenomenologically successful physical model for such parton distributions, which reduces the NuTeV result to only about two standard deviations from the Standard Model.Comment: 4 pages, 5 figures, RevTex4. Updated with new references and extended discussion. v.3: Minor corrections mad

On the formation of cyclones and anticyclones in a rotating fluid

It is commonly observed that the columnar vortices that dominate the large scales in homogeneous, rapidly rotating turbulence are predominantly cyclonic. This has prompted us to ask how this asymmetry arises. To provide a partial answer to this we look at the process of columnar vortex formation in a rotating fluid and, in particular, we examine how a localized region of swirl (an eddy) can convert itself into a columnar structure by inertial wave propagation. We show that, when the Rossby number (Ro) is small, the vortices evolve into columnar eddies through the radiation of linear inertial waves. When the Rossby number is large, on the other hand, no such column is formed. Rather, the eddy bursts radially outward under the action of the centrifugal force. There is no asymmetry between cyclonic and anticyclonic eddies for these two regimes. However, cyclones and anticyclones behave differently in the intermediate regime of Ro~1. Here we find that the transition from columnar vortex formation to radial bursting occurs at lower values of Ro for anticyclones, with the transition for anticyclones occurring at Ro~0.5, and that for cyclones at Ro~2. Thus, in a homogeneous turbulence experiment conducted at, say, Ro=1, we would expect to see more cyclones than anticyclones. The reason for this asymmetry at Ro~1 is explained

Wave Function of a Brane-like Universe

Within the mini-superspace model, brane-like cosmology means performing the variation with respect to the embedding (Minkowski) time $\tau$ before fixing the cosmic (Einstein) time $t$. The departure from Einstein limit is parameterized by the 'energy' conjugate to $\tau$, and characterized by a classically disconnected Embryonic epoch. In contrast with canonical quantum gravity, the wave-function of the brane-like Universe is (i) $\tau$-dependent, and (ii) vanishes at the Big Bang. Hartle-Hawking and Linde proposals dictate discrete 'energy' levels, whereas Vilenkin proposal resembles $\alpha$-particle disintegration.Comment: Revtex, 4 twocolumn pages, 3 eps figures (accepted for publication in Class. Quan. Grav.

Studies on Nucleic Acid Reassociation Kinetics: Retarded Rate of Hybridization of RNA with Excess DNA

The rate of reaction of excess double-stranded bacteriophage phi X174 and plasmid RSF2124 DNA drivers with enzymatically synthesized asymmetric RNA tracers was measured. Other reactions were carried out with excess Escherichia coli DNA and E. coli RNA labeled in vivo. RNA and DNA fragment lengths were held approximately equal. For each case it was shown that in DNA excess the rate constant for RNA· DNA hybridization is 3- to 4.5-fold lower than that of the renaturation rate constant for the driver DNA. This retardation was also observed in pseudo-first-order hybridization reactions driven by excess strand-separated RSF2124 DNA. It was concluded that the rate constant for RNA· DNA hybridization depends partially on which species is in excess

Prevention of osteoporotic refractures in regional Australia

Objective: Clinical guidelines recommend that patients who sustain a minimal trauma fracture (MTF) should receive a bone mineral density (BMD) scan and bisphosphonate (or equivalent) therapy if diagnosed with osteoporosis. A pilot fracture liaison service (FLS) was implemented in regional NSW to improve adherence to the guidelines. Design: Prospective cohort study with an historical control. Setting: Primary care. Participants: Control (n = 47) and cohort (n = 93) groups comprised patients consenting to interview who presented with a MTF to the major referral hospital 4 months before and 12 months after FLS implementation respectively. Main outcome measures: Primary outcome measures were the rates of BMD scans and anti-osteoporotic medication initiation/review after MTF. Hospital admission data were also examined to determine death and refracture rates for all patients presenting during the study period with a primary diagnosis of MTF within 3 years of their initial fracture. Results: Although there was no improvement in BMD scanning rates, the reported rate of medication initiation/review after fracture was significantly higher (P \u3c 0.05) in the FLS cohort. However, once adjusted for age, this association was not significant (P = 0.086). There was a lower refracture rate during the cohort period (P = 0.013), however, there were significantly more deaths (P = 0.035) within 3 years of initial fracture. When deaths were taken into account via competing risk regression, patients in the cohort period were significantly less likely to refracture than those in the control period (Hazard ratio = 0.576, P = 0.032). Conclusions: A rurally based nurse-led FLS was associated with modest improvement after MTF. Consideration should be given to ways to strengthen the model of care to improve outcomes

The LSST Data Mining Research Agenda

We describe features of the LSST science database that are amenable to scientific data mining, object classification, outlier identification, anomaly detection, image quality assurance, and survey science validation. The data mining research agenda includes: scalability (at petabytes scales) of existing machine learning and data mining algorithms; development of grid-enabled parallel data mining algorithms; designing a robust system for brokering classifications from the LSST event pipeline (which may produce 10,000 or more event alerts per night); multi-resolution methods for exploration of petascale databases; indexing of multi-attribute multi-dimensional astronomical databases (beyond spatial indexing) for rapid querying of petabyte databases; and more.Comment: 5 pages, Presented at the "Classification and Discovery in Large Astronomical Surveys" meeting, Ringberg Castle, 14-17 October, 200

Multistable alignment states in nematic liquid crystal filled wells

Two distinct, stable alignment states have been observed for a nematic liquid crystal confined in a layer with thickness of 12 μm and in square wells with sides of length between 20 and 80 μm. The director lies in the plane of the layer and line defects occur in two corners of the squares. The positions of the defects determine whether the director orientation is across the diagonal or is parallel to two opposite edges of the square. The device is multistable because both the diagonal and parallel states are stable when rotated by multiples of 90° in plane

Matrix Adhesion Polarizes Heart Progenitor Induction In The Invertebrate Chordate Ciona Intestinalis

Cell-matrix adhesion strongly influences developmental signaling. Resulting impacts on cell migration and tissue morphogenesis are well characterized. However, the in vivo impact of adhesion on fate induction remains ambiguous. Here, we employ the invertebrate chordate Ciona intestinalis to delineate an essential in vivo role for matrix adhesion in heart progenitor induction. In Ciona pre-cardiac founder cells, invasion of the underlying epidermis promotes localized induction of the heart progenitor lineage. We found that these epidermal invasions are associated with matrix adhesion along the pre-cardiac cell/epidermal boundary. Through targeted manipulations of RAP GTPase activity, we were able to manipulate pre-cardiac cell-matrix adhesion. Targeted disruption of pre-cardiac cell-matrix adhesion blocked heart progenitor induction. Conversely, increased matrix adhesion generated expanded induction. We were also able to selectively restore cell-matrix adhesion and heart progenitor induction through targeted expression of Ci-Integrin β2. These results indicate that matrix adhesion functions as a necessary and sufficient extrinsic cue for regional heart progenitor induction. Furthermore, time-lapse imaging suggests that cytokinesis acts as an intrinsic temporal regulator of heart progenitor adhesion and induction. Our findings highlight a potentially conserved role for matrix adhesion in early steps of vertebrate heart progenitor specification