Towards modeling of comprehensive assessment for licensing in higher education

In the modern society information technologies, services, quality become the determinative factors of success of any business. The questions of quality management are especially relevant in social sphere, since organization oriented on quality of its processes provides the improvement of people living standards. Information computer technologies (ICT) are the powerful tool for increasing the performance of decision-making processes. Formalization of management problems and adequate mathematical models provide ICT with techniques and methods of solving the application problems in different domains and improving business performance. Higher education is a unique social and economic environment. The quality of its functioning influences many processes of successive development of society.Therefore elaboration of ICT in higher education domain remains the challenging problem for specialists in computer sciences

High-frequency homogenization for periodic media

This article is available open access through the publisher’s website at the link below. Copyright @ 2010 The Royal Society.An asymptotic procedure based upon a two-scale approach is developed for wave propagation in a doubly periodic inhomogeneous medium with a characteristic length scale of microstructure far less than that of the macrostructure. In periodic media, there are frequencies for which standing waves, periodic with the period or double period of the cell, on the microscale emerge. These frequencies do not belong to the low-frequency range of validity covered by the classical homogenization theory, which motivates our use of the term ‘high-frequency homogenization’ when perturbing about these standing waves. The resulting long-wave equations are deduced only explicitly dependent upon the macroscale, with the microscale represented by integral quantities. These equations accurately reproduce the behaviour of the Bloch mode spectrum near the edges of the Brillouin zone, hence yielding an explicit way for homogenizing periodic media in the vicinity of ‘cell resonances’. The similarity of such model equations to high-frequency long wavelength asymptotics, for homogeneous acoustic and elastic waveguides, valid in the vicinities of thickness resonances is emphasized. Several illustrative examples are considered and show the efficacy of the developed techniques.NSERC (Canada) and the EPSRC

Коренное золотопроявление на «Территории» Олега Куваева (север Чукотского нагорья)

A sample of a gold-bearing quartz vein from the Upper-Ichuveem ore occurrence, discovered in the Triassic terrigenous complex in the north of the Chukotka Upland, the Oleg Kuvaev's “Territory”, had been comprehensively studied. The gross gold grade was estimated at 3–4 g / t. The vein includes quartz, native gold, sulfide-gold-silver solid solutions, alumoseladonite, aluminium-sulfate-phosphates Fe-Pb-Mg-Ca compound, apatite, pyrite, iron-titanium oxides, litharge, native phases composed of Fe (Ni), Ag-Pb-Bi, Fe-Al-PS-As, multicomponent ocher of hypergene origin. Native gold ranges from medium to fine. The vein contains particles of non-crystalline organic matter, which is close in composition of organic groups to polysaccharides. It is possible that the carbon particles found in the gold-quartz vein are of an abiogenic nature and can be compared with abiogenic condensed organelles in the products of modern volcanism. The data obtained make it possible to attribute the Upper Ichuveem gold ore occurrence to a low-sulfide gold-quartz formation, but with additional signs of gold-silver and polymetallic formations, which can be regarded as a favorable prerequisite for prospecting and exploration in Oleg Kuvaev's «Territory» not only of gold-placer deposits, but also of lode gold deposits.Комплексно исследован образец золотоносной кварцевой жилы с Верхне-Ичувеемского рудопроявления, выявленного в триасовом терригенном комплексе на севере Чукотского нагорья – «Территории» Олега Куваева. Валовое содержание золота оценивается в 3–4 г/т. В состав жилы входят кварц, самородное золото, сульфидно-золото-серебряные твердые растворы, алюмоселадонит, алюмо-сульфато-фосфаты Fe-Pb-Mg-Ca состава, апатит, пирит, железо-титановые оксиды, глёт, самородные фазы состава Fe (Ni), Ag-Pb-Bi, Fe-Al-P-S-As, поликомпонентные охры гипергенного происхождения. Самородное золото колеблется от средне- до высокопробного. В составе жилы обнаружены частицы некристаллического органического вещества, близкого по составу органических групп к полисахаридам. Не исключено, что выявленные в золотокварцевой жиле углеродные частицы имеют абиогенную природу и могут быть сопоставлены с абиогенными конденсированными органоидами в продуктах современного вулканизма. Полученные данные позволяют отнести Верхне-Ичувеемское золоторудное проявление к малосульфидной золотокварцевой формации, но с дополнительными признаками золотосеребряной и полиметаллических формаций, что можно расценивать как благоприятную предпосылку для поисков и разведок на «Территории» Олега Куваева не только золото-россыпных, но и золото-коренных месторождений

DISCRETE BREATHERS IN MONOATOMIC FCC CRYSTALS AU, PD

Методом молекулярной динамики в моноатомных ГЦК-кристаллах Au и Pd был получен дискретный бризер с жестким типом нелинейности. Изучены характеристики дискретного бризера, приведена зависимость частоты от амплитуды. Проведено исследование влияния начальных условий на характеристики дискретного бризера.By method of molecular dynamics in the monoatomic FCC crystals Au and Pd was obtained discrete breathers with a hard type of nonlinearity. The characteristics of discrete breathers, the dependence of frequency of the amplitude were received. The influence of the initial conditions on the characteristics of discrete breathers

Uncoupling of ATP-Mediated Calcium Signaling and Dysregulated Interleukin-6 Secretion in Dendritic Cells by Nanomolar Thimerosal

Dendritic cells (DCs), a rare cell type widely distributed in the soma, are potent antigen-presenting cells that initiate primary immune responses. DCs rely on intracellular redox state and calcium (Ca(2+)) signals for proper development and function, but the relationship between these two signaling systems is unclear. Thimerosal (THI) is a mercurial used to preserve vaccines and consumer products, and is used experimentally to induce Ca(2+) release from microsomal stores. We tested adenosine triphosphate (ATP)-mediated Ca(2+) responses of DCs transiently exposed to nanomolar THI. Transcriptional and immunocytochemical analyses show that murine myeloid immature DCs (IDCs) and mature DCs (MDCs) express inositol 1,4,5-trisphosphate receptor (IP(3)R) and ryanodine receptor (RyR) Ca(2+) channels, known targets of THI. IDCs express the RyR1 isoform in a punctate distribution that is densest near plasma membranes and within dendritic processes, whereas IP(3)Rs are more generally distributed. RyR1 positively and negatively regulates purinergic signaling because ryanodine (Ry) blockade a) recruited 80% more ATP responders, b) shortened ATP-mediated Ca(2+) transients > 2-fold, and c) produced a delayed and persistent rise (≥ 2-fold) in baseline Ca(2+). THI (100 nM, 5 min) recruited more ATP responders, shortened the ATP-mediated Ca(2+) transient (≥ 1.4-fold), and produced a delayed rise (≥ 3-fold) in the Ca(2+) baseline, mimicking Ry. THI and Ry, in combination, produced additive effects leading to uncoupling of IP(3)R and RyR1 signals. THI altered ATP-mediated interleukin-6 secretion, initially enhancing the rate of cytokine secretion but suppressing cytokine secretion overall in DCs. DCs are exquisitely sensitive to THI, with one mechanism involving the uncoupling of positive and negative regulation of Ca(2+) signals contributed by RyR1

Фотодинамическая инактивация Mycobacterium tuberculosis метиленовым синим in vitro

The objective: to investigate the anti-tuberculosis effect of laser photodynamic inactivation (PDI) of M. tuberculosis H37Rv in vitro by methylene blue (MB) in the minimum concentration (1 μg/ml) with laser radiation of 662 nm. Subjects and methods. A comparative analysis of the intensity of growth of Mycobacterium tuberculosis H37Rv after laser irradiation and laser FDI by MB with different doses of light energy was carried out. Results. Laser radiation with a wavelength of 662 nm was found to have an inhibitory effect on the growth of M. tuberculosis H37Rv. FDI of Mycobacterium tuberculosis was first registered in the presence of a minimum concentration of MB (1 µg/ml) which suppressed colony growth by 97 and 93% when they were processed by radiation with a wavelength of 662 nm with the lowest density of doses of light energy (46.9 and 93.75 J/cm2).Цель: исследование противотуберкулезных эффектов лазерной фотодинамической инактивации (ФДИ) M. tuberculosis H37Rv in vitro метиленовым синим (МС) в минимальной концентрации (1 мкг/мл) при лазерном излучении длиной волны 662 нм.Материалы и методы. Проведен сравнительный анализ интенсивности роста Mycobacterium tuberculosis H37Rv после лазерного облучения и лазерной ФДИ МС при различных дозах световой энергии.Результаты. Обнаружено, что лазерное излучение длиной волны 662 нм оказывает ингибирующее действие на ростовые свойства M. tuberculosis H37Rv. Впервые зарегистрирована ФДИ микобактерий туберкулеза в присутствии минимальной концентрации МС (1 мкг/мл), при которой реализуется подавление роста колоний на 97 и 93% при их обработке излучением длиной волны 662 нм с наименьшими значениями плотности доз световой энергии (46,9 и 93,75 Дж/см2)

ФОТОДИНАМИЧЕСКАЯ ИНАКТИВАЦИЯ MYCOBACTERIUM TUBERCULOSIS РАДАХЛОРИНОМ IN VITRO

Goal: to detect the best mode of in vitro photodynamic inactivation of M. tuberculosis by Radahlorin.Subjects and methods. The activity of culture of M. tuberculosis, H37Rv strain, photosensitized by 0.00005% Radohlorin was compared and the intensity of growth was assessed after photodynamic inactivation by different doses of light energy with 662 nm wavelength.Results. For the first time, anti-microbial properties of E6 chlorine in the form of medicamental photosensitizer (0.00005% Radohlorin) suppressing museum strain of M. tuberculosis of H37Rv were detected. Photoinactivation of M. tuberculosis depends on the dose and achieves its maximum in 10 minutes of light exposure with light energy of 0.5 W. Цель: выявить оптимальный режим фотодинамической инактивации (ФДИ) M. tuberculosis радахлорином in vitro.Материалы и методы. Проведен сравнительный анализ культуральной активности M. tuberculosis H37Rv, фотосенсибилизированных радахло- рином 0,00005%, с оценкой интенсивности роста после ФДИ различными дозами световой энергии с длиной волны 662 нм.Результаты. Впервые выявлены антимикобактериальные свойства хлорина Е6 в виде лекарственного фотосенсибилизатора (радахлорин 0,00005%) в отношении музейного штамма M. tuberculosis H37Rv. Фотоинактивация возбудителя дозозависима и достигает предельных значений через 10 мин светового воздействия при мощности световой энергии 0,5 Вт.

Polyurethane/<i>n</i>-Octadecane Phase-Change Microcapsules via Emulsion Interfacial Polymerization: The Effect of Paraffin Loading on Capsule Shell Formation and Latent Heat Storage Properties.

Organic phase-change materials (PCMs) hold promise in developing advanced thermoregulation and responsive energy systems owing to their high latent heat capacity and thermal reliability. However, organic PCMs are prone to leakages in the liquid state and, thus, are hardly applicable in their pristine form. Herein, we encapsulated organic PCM n-Octadecane into polyurethane capsules via polymerization of commercially available polymethylene polyphenylene isocyanate and polyethylene glycol at the interface oil-in-water emulsion and studied how various n-Octadecane feeding affected the shell formation, capsule structure, and latent heat storage properties. The successful shell polymerization and encapsulation of n-Octadecane dissolved in the oil core was verified by confocal microscopy and Fourier-transform infrared spectroscopy. The mean capsule size varied from 9.4 to 16.7 µm while the shell was found to reduce in thickness from 460 to 220 nm as the n-Octadecane feeding increased. Conversely, the latent heat storage capacity increased from 50 to 132 J/g corresponding to the growth in actual n-Octadecane content from 25% to 67% as revealed by differential scanning calorimetry. The actual n-Octadecane content increased non-linearly along with the n-Octadecane feeding and reached a plateau at 66-67% corresponded to 3.44-3.69 core-to-monomer ratio. Finally, the capsules with the reasonable combination of structural and thermal properties were evaluated as a thermoregulating additive to a commercially available paint

Комплексный характер влияния поликарбоновых и фосфоновых кислот на кристаллизацию солей кальция и магния в динамических условиях

The influence of water-soluble organic compounds (adipic, polyaspartic and phosphonic acids) and their compositions on the crystallization of calcium and magnesium salts in dynamic conditions has been studied. It is found that the induction period of phase formation increases in the presence of polyaspartic and phosphonic acids 2.3–5.2 times in the range of their content from 0.05 to 0.2 ppm. The results of XRD and electron microscopic studies confirm the change in the phase composition and morphology of the crystalline precipitate that is formed. The dibasic carboxylic acid influence on the induction period, composition and structure of the precipitate is much less. It is established that the composition of organic acids also increases the induction period of phase formation. The complex inhibitor provides an increase in the critical supersaturation level in the system. The phosphonic and carboxyl groups of the inhibitor interact with calcium and magnesium ions and block the crystallization nuclei. When interacting with the dicarboxylic acid and polyacid adsorption on the surface of the formed crystals, the microcrystals dissolve.Исследовано влияние водорастворимых органических соединений (адипиновой, полиаспартамовой и фосфоновой кислот) и их композиций на кристаллизацию солей кальция и магния в динамических условиях. Установлено, что индукционный период фазообразования увеличивается в присутствии полиаспартамовой и фосфоновой кислот в 2,3–5,2 раза в диапазоне их содержания от 0,05 до 0,2 ppm. Результаты рентгенофазового анализа и электронно-микроскопического исследования подтверждают изменение фазового состава и морфологии образующегося кристаллического осадка. Установлено, что влияние двухосновной карбоновой кислоты на индукционный период, состав и структуру осадка значительно меньше. Определено, что композиция органических кислот также увеличивает индукционный период фазообразования. Комплексный ингибитор обеспечивает повышение уровня критического пересыщения в системе. Фосфонатные и карбоксильные группы ингибитора взаимодействуют с ионами кальция и магния, блокируют зародыши кристаллизации. При взаимодействии с дикарбоновой кислотой и адсорбцией поликислоты на поверхности образующихся кристаллов микрокристаллы растворяются

ВЛИЯНИЕ ЛАЗЕРНОГО ИЗЛУЧЕНИЯ ДЛИНОЙ ВОЛНЫ 662 НМ НА РОСТ MYCOBACTERIUM TUBERCULOSIS IN VITRO

Goal of the study: to define the effect of various doses of laser radiation with 662 nm wave on the growth of M. tuberculosis in vitro.Materials and methods. Samples of mycobacterial suspension of M. tuberculosis H37Rv were processed by monopositional light radiation (λ = 662 nm) in six dosing regimens varying in power and duration of the exposure to the light. All samples of mycobacterial suspension of M. tuberculosis were inoculated on the solid nutritional media of Lowenstein-Jensen in triplets for each dose of the exposure to light. Cultures were incubated under 37°С for 90 days with weekly inspection of samples.Results. Continuous irradiation by diffused laser with 662 nm wave provides the most expressed bacteriostatic and bactericidal effects against M. tuberculosis H37Rv under the density of the energy dose of 234.5 and 703.5 of J/sq.cm. Such a dose was obtained through 5 and 15-minute exposure respectively. Цель исследования: установить in vitro влияние различных доз лазерного излучения длиной волны 662 нм на ростовые свойства M. tuberculosis.Материалы и методы. Воздействие на образцы микобактериальной взвеси M. tuberculosis H37Rv осуществляли непрерывным монопозиционным световым излучением (λ = 662 нм) в шести режимах дозирования, зависящих от мощности и длительности светового воздействия. Инокуляция всех образцов суспензий микобактерий туберкулеза осуществлялась на плотные питательные среды Левенштейна – Йенсена в триплетах для каждой дозы светового воздействия. Инкубация посевов осуществлялась при 37°С в течение 90 дней с еженедельным пересмотром образцов.Результаты. Непрерывное излучение полупроводникового лазера с длиной волны 662 нм обладает наиболее выраженными бактериостатическими и бактерицидными эффектами в отношении M. tuberculosis H37Rv при плотности дозы энергии 234,5 и 703,5 Дж/см2 . Такая доза была получена при 5- и 15-минутной экспозиции соответственно.