25 research outputs found
Nonlinear gravito-electrostatic waves in self-gravitating complex plasma in presence of ion-drag effects
Evaluation of Single Photon Emission Computerised Tomography (SPECT) using Tc99m-Tetrofosmin as a Diagnostic Modality for Recurrent Posterior Fossa Tumours
BACKGROUND: Brain Single Photon Emission Computerised Tomography
(SPECT) has been established as a potentially useful tool for the
assessment of recurrent brain tumours. Though brain SPECT is
exquisitely sensitive in detecting viable tumour tissue in the
supratentorial region, its efficacy has not been evaluated till date in
case of infratentorial posterior fossa tumours. AIM OF THE STUDY: To
evaluate the diagnostic utility of brain SPECT in differentiating
recurrence of tumour from post-radiation gliosis in the posterior fossa
of the brain. SUBJECTS AND METHODS: Twenty-one patients with primary
malignant posterior fossa brain tumour were evaluated by brain SPECT
with Tc99m-Tetrofosmin as the tumour-seeking agent. Clinical behaviour
of the tumour observed for a minimum period of one year after the SPECT
study was taken as the gold standard. STATISTICAL ANALYSIS: The
Chi-square test has been used to note the significance of the
association between the clinical outcome and the SPECT finding. In
addition, the sensitivity and specificity of brain SPECT were also
calculated. RESULT: Brain SPECT in 4 patients revealed increased tracer
concentration over the primary tumour bed, which was consistent with
recurrent tumour. The clinical course was consistent with tumour
recurrence in 13 of the 21 patients, which included 3 patients with
positive SPECT study and 10 patients with negative SPECT study. Brain
SPECT revealed recurrent tumour in 4 patients whereas clinical
follow-up suggested recurrence in 13 patients. The clinical course was
consistent with radiation necrosis in the remaining 8 patients. In 1
brain SPECT positive patient the clinical course was consistent with
post-radiation gliosis. CONCLUSION: This study demonstrates that brain
SPECT is not a sensitive diagnostic modality to differentiate recurrent
tumour from post-radiation gliosis in the posterior fossa of the brain
Cerebellar medulloblastoma presenting with skeletal metastasis
Medulloblastomas are highly malignant brain tumours, but only rarely produce skeletal metastases. No case of medulloblastoma has been documented to have produced skeletal metastases prior to craniotomy or shunt surgery. A 21-year-old male presented with pain in the hip and lower back with difficulty in walking of 3 months′ duration. Signs of cerebellar dysfunction were present hence a diagnosis of cerebellar neoplasm or skeletal tuberculosis with cerebellar abscess formation was considered. MRI of brain revealed a lesion in the cerebellum suggestive of medulloblastoma. Bone scan revealed multiple sites of skeletal metastases excluding the lumbar vertebrae. MRI of lumbar spine and hip revealed metastases to all lumbar vertebrae and both hips. Computed tomography-guided biopsy was obtained from the L3 vertebra, which revealed metastatic deposits from medulloblastoma. Cerebrospinal fluid cytology showed the presence of medulloblastoma cells. A final diagnosis of cerebellar medulloblastoma with skeletal metastases was made. He underwent craniotomy and histopathology confirmed medulloblastoma
Synthesis and characterization of poly(2-ethylhexyl acrylate) prepared via atom transfer radical polymerization, reverse atom transfer radical polymerization and radical polymerization
Case Report - Cerebellar medulloblastoma presenting with skeletal metastasis
Medulloblastomas are highly malignant brain tumours, but only rarely
produce skeletal metastases. No case of medulloblastoma has been
documented to have produced skeletal metastases prior to craniotomy or
shunt surgery. A 21-year-old male presented with pain in the hip and
lower back with difficulty in walking of 3 months' duration. Signs of
cerebellar dysfunction were present hence a diagnosis of cerebellar
neoplasm or skeletal tuberculosis with cerebellar abscess formation was
considered. MRI of brain revealed a lesion in the cerebellum suggestive
of medulloblastoma. Bone scan revealed multiple sites of skeletal
metastases excluding the lumbar vertebrae. MRI of lumbar spine and hip
revealed metastases to all lumbar vertebrae and both hips. Computed
tomography-guided biopsy was obtained from the L3 vertebra, which
revealed metastatic deposits from medulloblastoma. Cerebrospinal fluid
cytology showed the presence of medulloblastoma cells. A final
diagnosis of cerebellar medulloblastoma with skeletal metastases was
made. He underwent craniotomy and histopathology confirmed
medulloblastoma
Original Article - Evaluation of Single Photon Emission Computerised Tomography (SPECT) using Tc99m-Tetrofosmin as a Diagnostic Modality for Recurrent Posterior Fossa Tumours
BACKGROUND: Brain Single Photon Emission Computerised Tomography (SPECT) has been established as a potentially useful tool for the assessment of recurrent brain tumours. Though brain SPECT is exquisitely sensitive in detecting viable tumour tissue in the supratentorial region, its efficacy has not been evaluated till date in case of infratentorial posterior fossa tumours. AIM OF THE STUDY: To evaluate the diagnostic utility of brain SPECT in differentiating recurrence of tumour from post-radiation gliosis in the posterior fossa of the brain. SUBJECTS AND METHODS: Twenty-one patients with primary malignant posterior fossa brain tumour were evaluated by brain SPECT with Tc99m-Tetrofosmin as the tumour-seeking agent. Clinical behaviour of the tumour observed for a minimum period of one year after the SPECT study was taken as the gold standard. STATISTICAL ANALYSIS: The Chi-square test has been used to note the significance of the association between the clinical outcome and the SPECT finding. In addition, the sensitivity and specificity of brain SPECT were also calculated. RESULT: Brain SPECT in 4 patients revealed increased tracer concentration over the primary tumour bed, which was consistent with recurrent tumour. The clinical course was consistent with tumour recurrence in 13 of the 21 patients, which included 3 patients with positive SPECT study and 10 patients with negative SPECT study. Brain SPECT revealed recurrent tumour in 4 patients whereas clinical follow-up suggested recurrence in 13 patients. The clinical course was consistent with radiation necrosis in the remaining 8 patients. In 1 brain SPECT positive patient the clinical course was consistent with post-radiation gliosis. CONCLUSION: This study demonstrates that brain SPECT is not a sensitive diagnostic modality to differentiate recurrent tumour from post-radiation gliosis in the posterior fossa of the brain
Case Report - Cerebellar medulloblastoma presenting with skeletal metastasis
Medulloblastomas are highly malignant brain tumours, but only rarely produce skeletal metastases. No case of medulloblastoma has been documented to have produced skeletal metastases prior to craniotomy or shunt surgery. A 21-year-old male presented with pain in the hip and lower back with difficulty in walking of 3 months' duration. Signs of cerebellar dysfunction were present hence a diagnosis of cerebellar neoplasm or skeletal tuberculosis with cerebellar abscess formation was considered. MRI of brain revealed a lesion in the cerebellum suggestive of medulloblastoma. Bone scan revealed multiple sites of skeletal metastases excluding the lumbar vertebrae. MRI of lumbar spine and hip revealed metastases to all lumbar vertebrae and both hips. Computed tomography-guided biopsy was obtained from the L3 vertebra, which revealed metastatic deposits from medulloblastoma. Cerebrospinal fluid cytology showed the presence of medulloblastoma cells. A final diagnosis of cerebellar medulloblastoma with skeletal metastases was made. He underwent craniotomy and histopathology confirmed medulloblastoma