Noncausal telemetry data recovery techniques

Cost efficiency is becoming a major driver in future space missions. Because of the constraints on total cost, including design, implementation, and operation, future spacecraft are limited in terms of their size power and complexity. Consequently, it is expected that future missions will operate on marginal space-to-ground communication links that, in turn, can pose an additional risk on the successful scientific data return of these missions. For low data-rate and low downlink-margin missions, the buffering of the telemetry signal for further signal processing to improve data return is a possible strategy; it has been adopted for the Galileo S-band mission. This article describes techniques used for postprocessing of buffered telemetry signal segments (called gaps) to recover data lost during acquisition and resynchronization. Two methods, one for a closed-loop and the other one for an open-loop configuration, are discussed in this article. Both of them can be used in either forward or backward processing of signal segments, depending on where a gap is specifically situated in a pass

Inhibition of EZH2 Ameliorates Lupusâ Like Disease in MRL/lpr Mice

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151823/1/art40931_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151823/2/art40931.pd

Precision Pointing Control System (PPCS) system design and analysis

The precision pointing control system (PPCS) is an integrated system for precision attitude determination and orientation of gimbaled experiment platforms. The PPCS concept configures the system to perform orientation of up to six independent gimbaled experiment platforms to design goal accuracy of 0.001 degrees, and to operate in conjunction with a three-axis stabilized earth-oriented spacecraft in orbits ranging from low altitude (200-2500 n.m., sun synchronous) to 24 hour geosynchronous, with a design goal life of 3 to 5 years. The system comprises two complementary functions: (1) attitude determination where the attitude of a defined set of body-fixed reference axes is determined relative to a known set of reference axes fixed in inertial space; and (2) pointing control where gimbal orientation is controlled, open-loop (without use of payload error/feedback) with respect to a defined set of body-fixed reference axes to produce pointing to a desired target

Control landscapes for two-level open quantum systems

A quantum control landscape is defined as the physical objective as a function of the control variables. In this paper the control landscapes for two-level open quantum systems, whose evolution is described by general completely positive trace preserving maps (i.e., Kraus maps), are investigated in details. The objective function, which is the expectation value of a target system operator, is defined on the Stiefel manifold representing the space of Kraus maps. Three practically important properties of the objective function are found: (a) the absence of local maxima or minima (i.e., false traps); (b) the existence of multi-dimensional sub-manifolds of optimal solutions corresponding to the global maximum and minimum; and (c) the connectivity of each level set. All of the critical values and their associated critical sub-manifolds are explicitly found for any initial system state. Away from the absolute extrema there are no local maxima or minima, and only saddles may exist, whose number and the explicit structure of the corresponding critical sub-manifolds are determined by the initial system state. There are no saddles for pure initial states, one saddle for a completely mixed initial state, and two saddles for other initial states. In general, the landscape analysis of critical points and optimal manifolds is relevant to the problem of explaining the relative ease of obtaining good optimal control outcomes in the laboratory, even in the presence of the environment.Comment: Minor editing and some references adde

Overview of the results of the organics PET Study of the cometary samples returned from comet Wild 2 by the Stardust mission

This presenation will provide an overview of the efforts and results produced by the Organics Preliminary Examination Team during their studies of the samples returned from comet Wild 2 by the Stardust spacecraft

A Nonabelian Yang-Mills Analogue of Classical Electromagnetic Duality

The classic question of a nonabelian Yang-Mills analogue to electromagnetic duality is here examined in a minimalist fashion at the strictly 4-dimensional, classical field and point charge level. A generalisation of the abelian Hodge star duality is found which, though not yet known to give dual symmetry, reproduces analogues to many dual properties of the abelian theory. For example, there is a dual potential, but it is a 2-indexed tensor $T_{\mu\nu}$ of the Freedman-Townsend type. Though not itself functioning as such, $T_{\mu\nu}$ gives rise to a dual parallel transport, $\tilde{A}_\mu$, for the phase of the wave function of the colour magnetic charge, this last being a monopole of the Yang-Mills field but a source of the dual field. The standard colour (electric) charge itself is found to be a monopole of $\tilde{A}_\mu$. At the same time, the gauge symmetry is found doubled from say $SU(N)$ to $SU(N) \times SU(N)$. A novel feature is that all equations of motion, including the standard Yang-Mills and Wong equations, are here derived from a `universal' principle, namely the Wu-Yang (1976) criterion for monopoles, where interactions arise purely as a consequence of the topological definition of the monopole charge. The technique used is the loop space formulation of Polyakov (1980).Comment: We regret that, due to a technical hitch, parts of the reference list were mixed up. This is the corrected version. We apologize to the authors whose papers were misquote

Control of daughter centriole formation by the pericentriolar material

Author Posting. © The Author(s), 2008. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Cell Biology 10 (2008): 322-328, doi:10.1038/ncb1694.Controlling the number of its centrioles is vital for the cell as supernumerary centrioles result in multipolar mitosis and genomic instability. Normally, just one daughter centriole forms on each mature (mother) centriole; however, a mother centriole can produce multiple daughters within a single cell cycle. The mechanisms that prevent centriole ‘overduplication’ are poorly understood. Here we use laser microsurgery to test the hypothesis that attachment of the daughter centriole to the wall of the mother inhibits formation of additional daughters. We show that physical removal of the daughter induces reduplication of the mother in Sarrested cells. Under conditions when multiple daughters simultaneously form on a single mother, all of these daughters must be removed to induce reduplication. Intriguingly, the number of daughter centrioles that form during reduplication does not always match the number of ablated daughter centrioles. We also find that exaggeration of the pericentriolar material (PCM) via overexpression of the PCM protein pericentrin in S-arrested CHO cells induces formation of numerous daughter centrioles. We propose that that the size of the PCM cloud associated with the mother centriole restricts the number of daughters that can form simultaneously.This work was supported by grants from the National Institutes of Health (GM GM59363) and the Human Frontiers Science Program (RGP0064). Construction of our laser microsurgery workstation was supported in part by a fellowship from Nikon/Marine Biological Laboratory (A.K.)

miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes

MicroRNAs (miRNAs) are small non-coding RNA molecules that can negatively regulate gene expression and thus control numerous cellular mechanisms. This work develops a resource, miRNAMap 2.0, for collecting experimentally verified microRNAs and experimentally verified miRNA target genes in human, mouse, rat and other metazoan genomes. Three computational tools, miRanda, RNAhybrid and TargetScan, were employed to identify miRNA targets in 3′-UTR of genes as well as the known miRNA targets. Various criteria for filtering the putative miRNA targets are applied to reduce the false positive prediction rate of miRNA target sites. Additionally, miRNA expression profiles can provide valuable clues on the characteristics of miRNAs, including tissue specificity and differential expression in cancer/normal cell. Therefore, quantitative polymerase chain reaction experiments were performed to monitor the expression profiles of 224 human miRNAs in 18 major normal tissues in human. The negative correlation between the miRNA expression profile and the expression profiles of its target genes typically helps to elucidate the regulatory functions of the miRNA. The interface is also redesigned and enhanced. The miRNAMap 2.0 is now available at http://miRNAMap.mbc.nctu.edu.tw/