Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer

Abstract. Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We have developed a novel molecule, 2', 4'-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteoblasts cancer cell lines. Thionylation of 2', 4'- dihydroxydibenzoylmethane led to selective targeting of bone cancer cells, stopping their growth and leading to their death without affecting non-cancerous cells within the bone marrow or other non-malignant cells

Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures

An experimental study of cathodic protection for chloride contaminated reinforced concrete

Cathodic protection (CP) is being increasingly used on reinforced concrete structures to protect steel reinforcing bars from corrosion in aggressive conditions. Due to the complexity of environmental conditions, the design specifications in national and international standards are still open to discussion to achieve both sufficient and efficient protection for reinforced concrete structures in engineering practices. This paper reports an experimental research to investigate the influence of chloride content on concrete resistivity, rebar corrosion rate and the performance of CP operation using different current densities. It aims to understand the correlation between the chloride content and concrete resistivity together with the CP current requirement, and to investigate the precision of the CP design criteria in standards

The DELPHI detector at LEP

DELPHI is a 4π detector with emphasis on particle identification, three-dimensional information, high granularity and precise vertex determination. The design criteria, the construction of the detector and the performance during the first year of operation at the large electron positron collider (LEP) at CERN are described.0info:eu-repo/semantics/publishe

Study of hadronic decays of the ZO boson

Hadronic decays of Z0 bosons are studied in the Delphi detector. Global event variables and single particle inclusive distributions are compared with QCD-based predictions. The mean charged multiplicity is found to be 20.6±1.0 (stat+syst). The mean values of the sphericity, aplanarity, thrust, minor value, pin T and pout T are compared with values found at lower energy e+e- colliders.0SCOPUS: ar.jinfo:eu-repo/semantics/publishe

MEASUREMENT OF THE MASS AND WIDTH OF THE Z0 PARTICLE FROM MULTI - HADRONIC FINAL STATES PRODUCED IN e+ e- ANNIHILATIONS

First measurements of the mass and width of the Z0 performed at the newly commissioned LEP Collider by the DELPHI Collaboration are presented. The measuements are derived from the study of multihadronic final states produced in e+e- annihilations at several energies around the Z0 mass. The values found for the mass and width are M(Z0)=91.06±0.09 (stat) ±0.045 (syst.) GeV and Γ(Z0)=2.42±0.21 (stat.) GeV respectively, froma three-parameter fit to the line shape. A two-parameter fit in the framework of the standard model yields for the number of light neutrino species Nν=2.4±0.4 (stat.) ±0.5 (syst.)0SCOPUS: ar.jinfo:eu-repo/semantics/publishe