1,257 research outputs found
Right coronary artery—Pulmonary artery arteriovenous fistula secondary to open heart surgery
A patient is described who underwent atrial septal defect repair at age 12 and presented 16 years later with angina. Coronary angiography revealed a right coronary artery to pulmonary artery fistula that had developed at the site of the previous thoracotomy. This is the first report of an acquired fistula of this type developing secondary to trauma associated with open heart surgery. Diagnosis, shunt quantification and treatment are discussed
Semiclassical approach to discrete symmetries in quantum chaos
We use semiclassical methods to evaluate the spectral two-point correlation
function of quantum chaotic systems with discrete geometrical symmetries. The
energy spectra of these systems can be divided into subspectra that are
associated to irreducible representations of the corresponding symmetry group.
We show that for (spinless) time reversal invariant systems the statistics
inside these subspectra depend on the type of irreducible representation. For
real representations the spectral statistics agree with those of the Gaussian
Orthogonal Ensemble (GOE) of Random Matrix Theory (RMT), whereas complex
representations correspond to the Gaussian Unitary Ensemble (GUE). For systems
without time reversal invariance all subspectra show GUE statistics. There are
no correlations between non-degenerate subspectra. Our techniques generalize
recent developments in the semiclassical approach to quantum chaos allowing one
to obtain full agreement with the two-point correlation function predicted by
RMT, including oscillatory contributions.Comment: 26 pages, 8 Figure
Chaotic maps and flows: Exact Riemann-Siegel lookalike for spectral fluctuations
To treat the spectral statistics of quantum maps and flows that are fully
chaotic classically, we use the rigorous Riemann-Siegel lookalike available for
the spectral determinant of unitary time evolution operators . Concentrating
on dynamics without time reversal invariance we get the exact two-point
correlator of the spectral density for finite dimension of the matrix
representative of , as phenomenologically given by random matrix theory. In
the limit the correlator of the Gaussian unitary ensemble is
recovered. Previously conjectured cancellations of contributions of
pseudo-orbits with periods beyond half the Heisenberg time are shown to be
implied by the Riemann-Siegel lookalike
Microwave Realization of the Gaussian Symplectic Ensemble
This work was funded by the Deutsche Forschungsgemeinschaft via the individual Grants No. STO 157/16-1 and No. KU 1525/3-1. C. H. J. acknowledges the Leverhulme Trust (Grant No. ECF-2014-448) for financial support
Recognizing Intimate Partner Violence in Primary Care: Western Cape, South Africa
Introduction: Interpersonal violence in South Africa is the second highest contributor to the burden of disease after HIV/ AIDS and 62 % is estimated to be from intimate partner violence (IPV). This study aimed to evaluate how women experiencing IPV present in primary care, how often IPV is recognized by health care practitioners and what other diagnoses are made. Methods: At two urban and three rural community health centres, health practitioners were trained to screen all women fo
Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm
This paper describes Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm. It builds on the work of the previous paper "Approach to an Affordable and Productive Space Transportation System". The scope includes both flight and ground system elements, and focuses on their compatibility and capability to achieve a technical solution that is operationally productive and also affordable. A clear and revolutionary approach, including advanced propulsion systems (advanced LOX rich booster engine concept having independent LOX and fuel cooling systems, thrust augmentation with LOX rich boost and fuel rich operation at altitude), improved vehicle concepts (autogeneous pressurization, turbo alternator for electric power during ascent, hot gases to purge system and keep moisture out), and ground delivery systems, was examined. Previous papers by the authors and other members of the Space Propulsion Synergy Team (SPST) focused on space flight system engineering methods, along with operationally efficient propulsion system concepts and technologies. This paper continues the previous work by exploring the propulsion technology aspects in more depth and how they may enable the vehicle designs from the previous paper. Subsequent papers will explore the vehicle design, the ground support system, and the operations aspects of the new delivery paradigm in greater detail
Finite pseudo orbit expansions for spectral quantities of quantum graphs
We investigate spectral quantities of quantum graphs by expanding them as
sums over pseudo orbits, sets of periodic orbits. Only a finite collection of
pseudo orbits which are irreducible and where the total number of bonds is less
than or equal to the number of bonds of the graph appear, analogous to a cut
off at half the Heisenberg time. The calculation simplifies previous approaches
to pseudo orbit expansions on graphs. We formulate coefficients of the
characteristic polynomial and derive a secular equation in terms of the
irreducible pseudo orbits. From the secular equation, whose roots provide the
graph spectrum, the zeta function is derived using the argument principle. The
spectral zeta function enables quantities, such as the spectral determinant and
vacuum energy, to be obtained directly as finite expansions over the set of
short irreducible pseudo orbits.Comment: 23 pages, 4 figures, typos corrected, references added, vacuum energy
calculation expande
Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology
Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is unknown. To study this issue, here we develop a model of human central metabolism that incorporates a solvent capacity constraint of metabolic enzymes and mitochondria, accounting for their occupied volume densities, while assuming glucose and/or fatty acid utilization. The model demonstrates that activation of aerobic glycolysis is favored above a threshold metabolic rate in both rapidly proliferating cells and heavily contracting muscles, because it provides higher ATP yield per volume density than mitochondrial oxidative phosphorylation. In the case of muscle physiology, the model also predicts that before the lactate switch, fatty acid oxidation increases, reaches a maximum, and then decreases to zero with concomitant increase in glucose utilization, in agreement with the empirical evidence. These results are further corroborated by a larger scale model, including biosynthesis of major cell biomass components. The larger scale model also predicts that in proliferating cells the lactate switch is accompanied by activation of glutaminolysis, another distinctive feature of the Warburg effect. In conclusion, intracellular molecular crowding is a fundamental constraint for cell metabolism in both rapidly proliferating- and non-proliferating cells with high metabolic demand. Addition of this constraint to metabolic flux balance models can explain several observations of mammalian cell metabolism under steady state conditions
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