Origin of the peculiar eccentricity distribution of the inner cold Kuiper belt

Dawson and Murray-Clay (2012) pointed out that the inner part of the cold population in the Kuiper belt (that with semi major axis a<43.5 AU) has orbital eccentricities significantly smaller than the limit imposed by stability constraints. Here, we confirm their result by looking at the orbital distribution and stability properties in proper element space. We show that the observed distribution could have been produced by the slow sweeping of the 4/7 mean motion resonance with Neptune that accompanied the end of Neptune's migration process. The orbital distribution of the hot Kuiper belt is not significantly affected in this process, for the reasons discussed in the main text. Therefore, the peculiar eccentricity distribution of the inner cold population can not be unequivocally interpreted as evidence that the cold population formed in-situ and was only moderately excited in eccentricity; it can simply be the signature of Neptune's radial motion, starting from a moderately eccentric orbit. We discuss how this agrees with a scenario of giant planet evolution following a dynamical instability and, possibly, with the radial transport of the cold population.Comment: in press in Icaru

Drug enrichment and discovery from schizophrenia genome-wide association results:an analysis and visualisation approach

Using successful genome-wide association results in psychiatry for drug repurposing is an ongoing challenge. Databases collecting drug targets and gene annotations are growing and can be harnessed to shed a new light on psychiatric disorders. We used genome-wide association study (GWAS) summary statistics from the Psychiatric Genetics Consortium (PGC) Schizophrenia working group to build a drug repositioning model for schizophrenia. As sample size increases, schizophrenia GWAS results show increasing enrichment for known antipsychotic drugs, selective calcium channel blockers, and antiepileptics. Each of these therapeutical classes targets different gene subnetworks. We identify 123 Bonferroni-significant druggable genes outside the MHC, and 128 FDR-significant biological pathways related to neurons, synapses, genic intolerance, membrane transport, epilepsy, and mental disorders. These results suggest that, in schizophrenia, current well-powered GWAS results can reliably detect known schizophrenia drugs and thus may hold considerable potential for the identification of new therapeutic leads. Moreover, antiepileptics and calcium channel blockers may provide repurposing opportunities. This study also reveals significant pathways in schizophrenia that were not identified previously, and provides a workflow for pathway analysis and drug repurposing using GWAS results

The first 40 million years of circumstellar disk evolution: the signature of terrestrial planet formation

We characterize the first 40 Myr of evolution of circumstellar disks through a unified study of the infrared properties of members of young clusters and associations with ages from 2 Myr up to ~ 40 Myr: NGC 1333, NGC 1960, NGC 2232, NGC 2244, NGC 2362, NGC 2547, IC 348, IC 2395, IC 4665, Chamaeleon I, Orion OB1a and OB1b, Taurus, the \b{eta} Pictoris Moving Group, \r{ho} Ophiuchi, and the associations of Argus, Carina, Columba, Scorpius-Centaurus, and Tucana-Horologium. Our work features: 1.) a filtering technique to flag noisy backgrounds, 2.) a method based on the probability distribution of deflections, P(D), to obtain statistically valid photometry for faint sources, and 3.) use of the evolutionary trend of transitional disks to constrain the overall behavior of bright disks. We find that the fraction of disks three or more times brighter than the stellar photospheres at 24 {\mu}m decays relatively slowly initially and then much more rapidly by ~ 10 Myr. However, there is a continuing component until ~ 35 Myr, probably due primarily to massive clouds of debris generated in giant impacts during the oligarchic/chaotic growth phases of terrestrial planets. If the contribution from primordial disks is excluded, the evolution of the incidence of these oligarchic/chaotic debris disks can be described empirically by a log-normal function with the peak at 12 - 20 Myr, including ~ 13 % of the original population, and with a post-peak mean duration of 10 - 20 Myr.Comment: accepted for publication, the Astrophysical Journal (2017

The Dynamic Transition of Protein Hydration Water

Thin layers of water on biomolecular and other nanostructured surfaces can be supercooled to temperatures not accessible with bulk water. Chen et al. [PNAS 103, 9012 (2006)] suggested that anomalies near 220 K observed by quasi-elastic neutron scattering can be explained by a hidden critical point of bulk water. Based on more sensitive measurements of water on perdeuterated phycocyanin, using the new neutron backscattering spectrometer SPHERES, and an improved data analysis, we present results that show no sign of such a fragile-to-strong transition. The inflection of the elastic intensity at 220 K has a dynamic origin that is compatible with a calorimetric glass transition at 170 K. The temperature dependence of the relaxation times is highly sensitive to data evaluation; it can be brought into perfect agreement with the results of other techniques, without any anomaly.Comment: 4 pages, 3 figures. Phys. Rev. Lett. (in press

Multiple Myeloma and AL Amyloidosis

O mieloma múltiplo e a amiloidose de cadeias leves (AL) de imunoglobulina são doenças proliferativas plasmocitárias incuráveis que raramente coexistem. Cerca de 10 a 15% dos doentes com mieloma múltiplo desenvolvem amiloidose AL clinicamente sintomática, sendo a situação inversa muito rara (0,4%). Apresenta-se um caso não previamente diagnosticado de mieloma múltiplo não secretor, isto é, sem identificação de paraproteína na imunoelectroforese ou imunofixação sérica ou urinária, numa doente internada por icterícia pruriginosa e volumosa hepatomegália. A biópsia hepática confirmou o diagnóstico de amiloidose e o doseamento sérico das cadeias leves livres das imunoglobulinas revelou hiperprodução de cadeias leves kappa (k). Os autores abordam as particularidades clínicas e de investigação destas duas entidades em que o diagnóstico precoce e a terapêutica atempada influenciam o prognóstico

The HR 4796A Debris System: Discovery of Extensive Exo-Ring Dust Material

The optically and IR bright, and starlight-scattering, HR 4796A ring-like debris disk is one of the most (and best) studied exoplanetary debris systems. The presence of a yet-undetected planet has been inferred (or suggested) from the narrow width and inner/outer truncation radii of its r = 1.05" (77 au) debris ring. We present new, highly sensitive, Hubble Space Telescope (HST) visible-light images of the HR 4796A circumstellar debris system and its environment over a very wide range of stellocentric angles from 0.32" (23 au) to ~ 15" (1100 au). These very high contrast images were obtained with the Space Telescope Imaging Spectrograph (STIS) using 6-roll PSF-template subtracted coronagraphy suppressing the primary light of HR 4796A and using three image plane occulters and simultaneously subtracting the background light from its close angular proximity M2.5V companion. The resulting images unambiguously reveal the debris ring embedded within a much larger, morphologically complex, and bi-axially asymmetric exoring scattering structure. These images at visible wavelengths are sensitive to, and map, the spatial distribution, brightness, and radial surface density of micron size particles over 5 dex in surface brightness. These particles in the exo-ring environment may be unbound from the system and interacting with the local ISM. Herein we present a new morphological and photometric view of the larger than prior seen HR 4796A exoplanetary debris system with sensitivity to small particles at stellocentric distances an order of magnitude greater than has previously been observed.Comment: 28 pages, 17 figures, accepted for publication in the Astronomical Journal 21 December 201

Information to the eye of the beholder: data visualization for many-objective optimization

The visualization gap is one of the important challenges posed by many-objective optimization problems (MaOPs). In this paper, we present an integrated data visualization method for MaOPs, called CAP-vis plot, combining the Chord diagram, the Angular mapping and the Parallel coordinates in the same visualization. The method follows the circular design layout, showing different levels of information. This new approach allows the spatial location of points in high dimensional spaces, the visualization of harmony and conflict between objectives, as well as the comparison of the approximation sets provided by different algorithms. With this work, we try to fill the visualization gap and bring information to the eye of the decision-maker and the optimizer, with an intuitive overview of the obtained results. Some experiments were performed using the Benchmark Functions proposed for the IEEE-CEC 2018 Competition on Many-Objective Optimization. We used the tool to visualize the results obtained by NSGA-III, HypE, RVEA, MOEA/DD, PICEA-g, using the PlatEMO MATLAB platform, with the same parameter settings of the competition. The results on the Benchmark Problems show the importance of the qualitative analysis of the data. The experiments show how visualization can help interpretation of the results and identification of strengths and drawbacks of MOEA.The authors would like to thank the Brazilian agencies CAPES, CNPq and FAPEMIG for the financial support

Congenital Lobar Emphysema: A Multilobar Presentation

O enfisema lobar congénito é umamalformação rara do tracto respiratório inferior detectada habitualmente nos primeiros meses de vida. Apresenta-se o caso de um lactente, do sexo masculino, de dois meses de idade, internado por suspeita de pneumonia, no qual a segunda radiografia de tórax revelou hipertransparência arredondada no lobo inferior esquerdo, sugestiva de enfisema lobar congénito. A tomografia computorizada torácica mostrou uma imagem quística,multilobar, e a broncoscopia excluiu obstrução brônquica. Foi programada cirurgia para os seis meses de idade, mas aos três meses foi submetido a intervenção cirúrgica urgente por pneumotórax hipertensivo. O exame anatomo-patológico da peça operatória permitiu o diagnóstico de enfisema lobar congénito. Destaca-se a apresentação multilobar e a complicação por pneumotórax

Protoplanetary and Transitional Disks in the Open Stellar Cluster IC 2395

We present new deep UBVRI images and high-resolution multi-object optical spectroscopy of the young (~ 6 - 10 Myr old), relatively nearby (800 pc) open cluster IC 2395. We identify nearly 300 cluster members and use the photometry to estimate their spectral types, which extend from early B to middle M. We also present an infrared imaging survey of the central region using the IRAC and MIPS instruments on board the Spitzer Space Telescope, covering the wavelength range from 3.6 to 24 microns. Our infrared observations allow us to detect dust in circumstellar disks originating over a typical range of radii ~ 0.1 to ~ 10AU from the central star. We identify 18 Class II, 8 transitional disk, and 23 debris disk candidates, respectively 6.5%, 2.9%, and 8.3% of the cluster members with appropriate data. We apply the same criteria for transitional disk identification to 19 other stellar clusters and associations spanning ages from ~ 1 to ~ 18 Myr. We find that the number of disks in the transitional phase as a fraction of the total with strong 24 micron excesses ([8] - [24] > 1.5) increases from 8.4 +\- 1.3% at ~ 3 Myr to 46 +\- 5% at ~ 10 Myr. Alternative definitions of transitional disks will yield different percentages but should show the same trend.Comment: accepted by the Astrophysical Journa