A non-LTE study of neutral and singly-ionized iron line spectra in 1D models of the Sun and selected late-type stars

A comprehensive model atom for Fe with more than 3000 energy levels is presented. As a test and first application of this model atom, Fe abundances are determined for the Sun and five stars with well determined stellar parameters and high-quality observed spectra. Non-LTE leads to systematically depleted total absorption in the Fe I lines and to positive abundance corrections in agreement with the previous studies, however, the magnitude of non-LTE effect is smaller compared to the earlier results. Non-LTE corrections do not exceed 0.1 dex for the solar metallicity and mildly metal-deficient stars, and they vary within 0.21 dex and 0.35 dex in the very metal-poor stars HD 84937 and HD 122563, respectively, depending on the assumed efficiency of collisions with hydrogen atoms. Based on the analysis of the Fe I/Fe II ionization equilibrium in these two stars, we recommend to apply the Drawin formalism in non-LTE studies of Fe with a scaling factor of 0.1. For the Fe II lines, non-LTE corrections do not exceed 0.01 dex in absolute value. The solar non-LTE abundance obtained from 54 Fe I lines is 7.56+-0.09 and the abundance from 18 Fe II lines varies between 7.41+-0.11 and 7.56+-0.05 depending on the source of the gf-values. Thus, gf-values available for the iron lines are not accurate enough to pursue high-accuracy absolute abundance determinations. Lines of Fe I give, on average, a 0.1 dex lower abundance compared to those of Fe II lines for HD 61421 and HD 102870, even when applying a differential analysis relative to the Sun. A disparity between Fe I and Fe II points to problems of stellar atmosphere modelling or/and effective temperature determination.Comment: 19 pages, 8 figures, online material, accepted by A&

Immunotherapy for Pediatric Cancer

AbstractImprovements in adult cancer survivorship can be achieved from behavioral changes and adopting screening programs. Yet, these approaches cannot be readily applied to lower the morbidity and mortality from childhood cancers. Rather, pediatric oncologists must rely on procedures and therapies to treat, rather than prevent malignancies. The systematic application of chemotherapy, radiation therapy, and surgery has led to remarkable advances in survival but these improvements have come at a cost. Children routinely receive chemotherapy agents that were designed decades ago, and these drugs have predictable side effects that result in the loss of potential for long-term survivors. The advent of targeted applications of immune-based therapies offers children with cancer a new class of oncolytic therapies that may be used to treat disease refractory to conventional approaches and lessen the toxicity of current treatment regimens without compromising remission. This review explores how 3 components of the immune system—T cells, natural killer (NK) cells, and antibodies—can be used for therapy of pediatric malignancies

Temperature-Dependent Refractive Index Measurements of Caf2, Suprasil 3001, and S-FTM16 for the Euclid Near Infrared Spectrometer and Photometer

Using the Cryogenic High Accuracy Refraction Measuring System (CHARMS) at NASA's Goddard Space Flight Center, we measured absolute refractive indices at temperatures from 100 to 310 K at wavelengths from 0.42 to 3.6 microns for CaF2, Suprasil 3001 fused silica, and S-FTM16 glass in support of lens designs for the Near Infrared Spectrometer and Photometer (NISP) for ESA's Euclid dark energy mission. We report absolute refractive index, dispersion (dn/d), and thermo-optic coefficient (dn/dT) for these materials. In this study, materials from different melts were procured to understand index variability in each material. We provide temperature-dependent Sellmeier coefficients based on our data to allow accurate interpolation of index to other wavelengths and temperatures. For calcium fluoride (CaF2) and S-FTM16, we compare our current measurements with CHARMS measurements of these materials made in the recent past for other programs. We also compare Suprasil 3001's indices to those of other forms of fused silica we have measured in CHARMS

Collective Feshbach scattering of a superfluid droplet from a mesoscopic two-component Bose-Einstein condensate

We examine the collective scattering of a superfluid droplet impinging on a mesoscopic Bose-Einstein condensate (BEC) as a target. The BEC consists of an atomic gas with two internal electronic states, each of which is trapped by a finite-depth external potential. An off-resonant optical laser field provides a localized coupling between the BEC components in the trapping region. This mesoscopic scenario matches the microscopic setup for Feshbach scattering of two particles, when a bound state of one sub-manifold is embedded in the scattering continuum of the other sub-manifold. Within the mean-field picture, we obtain resonant scattering phase shifts from a linear response theory in agreement with an exact numerical solution of the real time scattering process and simple analytical approximations thereof. We find an energy-dependent transmission coefficient that is controllable via the optical field between 0 and 100%.Comment: 4 Latex pages, including 4 figure

Optical properties of tungsten thin films perforated with a bidimensional array of subwavelength holes

We present a theorical investigation of the optical transmission of a dielectric grating carved in a tungsten layer. For appropriate wavelengths tungsten shows indeed a dielectric behaviour. Our numerical simulations leads to theoretical results similar to those found with metallic systems studied in earlier works. The interpretation of our results rests on the idea that the transmission is correlated with the resonant response of eigenmodes coupled to evanescent diffraction orders.Comment: 4 pages, 3 figure

Histopathological Analysis of PEEK Wear Particle Effects on the Synovial Tissue of Patients

Introduction. Increasing interest developed in the use of carbon-fiber-reinforced-poly-ether-ether-ketones (CFR-PEEK) as an alternative bearing material in knee arthroplasty. The effects of CFR-PEEK wear in in vitro and animal studies are controversially discussed, as there are no data available concerning human tissue. The aim of this study was to analyze human tissue containing CFR-PEEK as well as UHMWPE wear debris. The authors hypothesized no difference between the used biomaterials. Methods and Materials. In 10 patients during knee revision surgery of a rotating-hinge-knee-implant-design, synovial tissue samples were achieved (tibial inserts: UHMWPE;bushings and flanges: CFR-PEEK). One additional patient received revision surgery without any PEEK components as a control. The tissue was paraffin-embedded, sliced into 2 mu m thick sections, and stained with hematoxylin and eosin in a standard process. A modified panoptical staining was also done. Results. A "wear-type" reaction was seen in the testing and the control group. In all samples, the UHMWPE particles were scattered in the tissue or incorporated in giant cells. CFR-PEEK particles were seen as conglomerates and only could be found next to vessels. CFR-PEEK particles showed no giant-cell reactions. In conclusion, the hypothesis has to be rejected. UHMWPE and PEEK showed a different scatter-behavior in human synovial tissue

Primary stability of a press-fit cup in combination with impaction grafting in an acetabular defect model

The objectives of this study were to (a) assess primary stability of a press-fit cup in a simplified acetabular defect model, filled with compacted cancellous bone chips, and (b) to compare the results with primary stability of a press-fit cup combined with two different types of bone graft substitute in the same defect model. A previously developed acetabular test model made of polyurethane foam was used, in which a mainly medial contained defect was implemented. Three test groups (N = 6 each) were prepared: Cancellous bone chips (bone chips), tricalciumphosphate tetrapods + collagen matrix (tetrapods + coll), bioactive glass S53P4 + polyethylene glycol-glycerol matrix (b.a.glass + PEG). Each material was compacted into the acetabulum and a press-fit cup was implanted. The specimens were loaded dynamically in the direction of the maximum resultant force during level walking. Relative motion between cup and test model was assessed with an optical measurement system. At the last load step (3000 N), inducible displacement was highest for bone chips with median [25th percentile; 75th percentile] value of 113 [110; 114] µm and lowest for b.a.glass + PEG with 91 [89; 93] µm. Migration at this load step was highest for b.a.glass + PEG with 868 [845; 936] µm and lowest for tetrapods + coll with 491 [487; 497] µm. The results show a comparable behavior under load of tetrapods + coll and bone chips and suggest that tetrapods + coll could be an attractive alternative to bone chips. However, so far, this was found for one specific defect type and primary stability should be further investigated in additional/more severe defects