38,199 research outputs found
Controlling secretion to limit chemoresistance
The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence. Interestingly, senescent endothelial cells do not mount a typical senescence-associated secretory phenotype but instead acutely secrete IL-6, promoting chemoresistance. This study unveils a physiological switch involving PI3K/AKT/mTOR signaling that restrains the senescence secretory responses to limit the detrimental consequences of persistent inflammation
Near field and far field scattering of surface plasmon polaritons by one-dimensional surface defects
A rigorous formulation for the scattering of surface plasmon polaritons (SPP)
from a one-dimensional surface defect of any shape that yields the
electromagnetic field in the vacuum half-space above the vacuum-metal interface
is developed by the use of an impedance boundary condition. The electric and
magnetic near fields, the angular distribution of the far-field radiation into
vacuum due to SPP-photon coupling, and the SPP reflection and transmission
coefficients are calculated by numerically solving the k-space integral
equation upon which the formulation is based. In particular, we consider
Gaussian-shaped defects and study the dependence of the above mentioned
physical quantities on their 1/e half-width a and height h. SPP reflection is
significant for narrow defects; maximum reflection (plasmon mirrors) is
achieved for a~lambda/10. For increasing defect widths, protuberances and
indentations behave differently. The former give rise to a monotonic increase
of radiation at the expense of SPP transmission for increasing defect
half-width. Indentations exhibit a significant increase of radiation (decrease
of SPP transmission) for half-widths of the order of or smaller than the
wavelength, but tend to total SPP transmission in an oscillatory manner upon
further increasing the half-width. Light-emitters might thus be associated with
either wide indentations, or protuberances with widths that are of the order of
or smaller than the wavelength.Comment: REVTeX 3.1, 10 pages with 9 EPS figures (epsf macro
Frequency dependence of pulsar radiation patterns
We report on new results from simultaneous, dual frequency, single pulse
observation of PSR B0329+54 using the Giant Metrewave Radio Telescope. We find
that the longitude separation of subpulses at two different frequencies (238
and 612 MHz) is less than that for the corresponding components in the average
profile. A similar behaviour has been noticed before in a number of pulsars. We
argue that subpulses are emitted within narrow flux tubes of the dipolar field
lines and that the mean pulsar beam has a conal structure. In such a model the
longitudes of profile components are determined by the intersection of the line
of sight trajectory with subpulse-associated emission beams. Thus, we show that
the difference in the frequency dependence of subpulse and profile component
longitudes is a natural property of the conal model of pulsar emission beam. We
support our conclusions by numerical modelling of pulsar emission, using the
known parameters for this pulsar, which produce results that agree very well
with our dual frequency observations.Comment: 24 pages, 8 figures. Accepted for publication in Ap
A conic manifold perspective of elliptic operators on graphs
We give a simple, explicit, sufficient condition for the existence of a
sector of minimal growth for second order regular singular differential
operators on graphs. We specifically consider operators with a singular
potential of Coulomb type and base our analysis on the theory of elliptic cone
operators.Comment: 18 page
Adjoints of elliptic cone operators
We study the adjointness problem for the closed extensions of a general
b-elliptic operator A in x^{-\nu}Diff^m_b(M;E), \nu>0, initially defined as an
unbounded operator A:C_c^\infty(M;E)\subset x^\mu L^2_b(M;E)\to x^\mu
L^2_b(M;E), \mu \in \R. The case where A is a symmetric semibounded operator is
of particular interest, and we give a complete description of the domain of the
Friedrichs extension of such an operator.Comment: 40 pages, LaTeX, preliminary versio
Gravitational Waves from Abelian Gauge Fields and Cosmic Strings at Preheating
Primordial gravitational waves provide a very important stochastic background
that could be detected soon with interferometric gravitational wave antennas or
indirectly via the induced patterns in the polarization anisotropies of the
cosmic microwave background. The detection of these waves will open a new
window into the early Universe, and therefore it is important to characterize
in detail all possible sources of primordial gravitational waves. In this paper
we develop theoretical and numerical methods to study the production of
gravitational waves from out-of-equilibrium gauge fields at preheating. We then
consider models of preheating after hybrid inflation, where the symmetry
breaking field is charged under a local U(1) symmetry. We analyze in detail the
dynamics of the system in both momentum and configuration space, and show that
gauge fields leave specific imprints in the resulting gravitational wave
spectra, mainly through the appearence of new peaks at characteristic
frequencies that are related to the mass scales in the problem. We also show
how these new features in the spectra correlate with string-like spatial
configurations in both the Higgs and gauge fields that arise due to the
appearance of topological winding numbers of the Higgs around Nielsen-Olesen
strings. We study in detail the time evolution of the spectrum of gauge fields
and gravitational waves as these strings evolve and decay before entering a
turbulent regime where the gravitational wave energy density saturates.Comment: This paper is dedicated to the memory of Lev Kofman. Added references
and comments in Sec. III.B. Version accepted in PR
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