2,115 research outputs found
A direct solver with O(N) complexity for variable coefficient elliptic PDEs discretized via a high-order composite spectral collocation method
A numerical method for solving elliptic PDEs with variable coefficients on
two-dimensional domains is presented. The method is based on high-order
composite spectral approximations and is designed for problems with smooth
solutions. The resulting system of linear equations is solved using a direct
(as opposed to iterative) solver that has optimal O(N) complexity for all
stages of the computation when applied to problems with non-oscillatory
solutions such as the Laplace and the Stokes equations. Numerical examples
demonstrate that the scheme is capable of computing solutions with relative
accuracy of or better, even for challenging problems such as highly
oscillatory Helmholtz problems and convection-dominated convection diffusion
equations. In terms of speed, it is demonstrated that a problem with a
non-oscillatory solution that was discretized using nodes was solved
in 115 minutes on a personal work-station with two quad-core 3.3GHz CPUs. Since
the solver is direct, and the "solution operator" fits in RAM, any solves
beyond the first are very fast. In the example with unknowns, solves
require only 30 seconds.Comment: arXiv admin note: text overlap with arXiv:1302.599
Story in health and social care
This paper offers a brief consideration of how narrative, in the form of peopleās own stories, potentially figures in health and social care provision as part of the impulse towards patient-centred care. The rise of the epistemological legitimacy of patientsā stories is sketched here. The paper draws upon relevant literature and original writing to consider the ways in which stories can mislead as well as illuminate the process of making individual treatment care plans
DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors
Capuramycin displays a narrow spectrum of antibacterial activity by targeting bacterial translocase I (MraY). In our program of development of new N-acetylglucosaminephosphotransferase1 (DPAGT1) inhibitors, we have identified that a capuramycin phenoxypiperidinylbenzylamide analogue (CPPB) inhibits DPAGT1 enzyme with an ICā
ā value of 200 nM. Despite a strong DPAGT1 inhibitory activity, CPPB does not show cytotoxicity against normal cells and a series of cancer cell lines. However, CPPB inhibits migrations of several solid cancers including pancreatic cancers that require high DPAGT1 expression in order for tumor progression. DPAGT1 inhibition by CPPB leads to a reduced expression level of Snail but does not reduce E-cadherin expression level at the ICā
ā (DPAGT1) concentration. CPPB displays a strong synergistic effect with paclitaxel against growth-inhibitory action of a patient-derived pancreatic adenocarcinoma, PD002: paclitaxel (ICā
ā: 1.25 Ī¼M) inhibits growth of PD002 at 0.0024ā0.16 Ī¼M in combination with 0.10ā2.0 Ī¼M CPPB (ICā
ā: 35 Ī¼M)
DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors
Capuramycin displays a narrow spectrum of antibacterial activity by targeting bacterial translocase I (MraY). In our program of development of new N-acetylglucosaminephosphotransferase1 (DPAGT1) inhibitors, we have identified that a capuramycin phenoxypiperidinylbenzylamide analogue (CPPB) inhibits DPAGT1 enzyme with an ICā
ā value of 200 nM. Despite a strong DPAGT1 inhibitory activity, CPPB does not show cytotoxicity against normal cells and a series of cancer cell lines. However, CPPB inhibits migrations of several solid cancers including pancreatic cancers that require high DPAGT1 expression in order for tumor progression. DPAGT1 inhibition by CPPB leads to a reduced expression level of Snail but does not reduce E-cadherin expression level at the ICā
ā (DPAGT1) concentration. CPPB displays a strong synergistic effect with paclitaxel against growth-inhibitory action of a patient-derived pancreatic adenocarcinoma, PD002: paclitaxel (ICā
ā: 1.25 Ī¼M) inhibits growth of PD002 at 0.0024ā0.16 Ī¼M in combination with 0.10ā2.0 Ī¼M CPPB (ICā
ā: 35 Ī¼M)
Influence of Maternal Obesity on Insulin Sensitivity and Secretion in Offspring
OBJECTIVEāThe purpose of this study was to clarify the effects of maternal obesity on insulin sensitivity and secretion in offspring
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