The innovative development of the industrial economy of Russia

Building an efficient management system by innovative development of the industrial economy is a priority for many countries. At that the importance of innovative processes for improving the stability of dynamics and the balance of proportions of the reproduction process in the economy increases. The paper contains an analysis of the key indicators of innovative development of the industrial economy of the key areas in which the essential part of Russian industrial assets is centered. The analysis is based on the data of the Russian Statistics Service and includes the indicators of the following sectors: production, economy and innovations. The author proposes to use the indicators of the strategic positioning of Russian companies in assessing innovative development, to take account of the programs of cooperation in the sphere of innovations. The potential and prospects of innovative development will largely be determined by the resource potential and the level of development of human capital in Russian companies

Bioinformatic Analysis of Immunodominant Peptides of Rabies Virus (<i>Rabies lyssavirus, Rhabdoviridae</i>)

There is a need to develop a new generation of anti-rabies vaccines that provide a protective level of antibodies after a single injection. Prospects for solving this problem are opened by the latest developments in the field of “reverse vaccinology”. The main parameter that determines the effectiveness of recombinant vaccines is the design of the antigen-coding sequence. In this regard, the aim of the work was to conduct a bioinformatic analysis of rabies virus (Rabies lyssavirus, Rhabdoviridae) peptides to identify immunogenic epitopes.Materials and methods. Analysis of 5 candidate protein sequences of more than 100 strains and epizootic isolates of the rabies virus was performed using standard in silico prediction methods using Immune Epitope Database (IEDB) (NIH, USA).Results and discussion. As a result of the analysis of primary amino acid sequences, carried out using the most commonly used bioinformatics tools, the number of immunogenic epitopes and the types of immune response detected (T- and B-cell epitopes, class I MHCbinding epitopes) were established for viral proteins: glycoprotein (G), nucleoprotein (N), phosphoprotein (P), matrix protein (M), RNA-dependent RNA polymerase (L). In the amino acid structure of these proteins, N- and O-glycosylation sites, signal peptides, and transmembrane domains were additionally identified. In order to predict the safety and efficacy of these proteins as components of recombinant vaccines, an in silico assessment of their physicochemical properties was carried out. Despite the fact that the predominant number of epitopes is concentrated in the structure of the glycoprotein, the epitopes of other proteins, ranging according to the level of antigenicity and conservatism, may also be of interest as components of preventive drugs or diagnostics. The presented data can be used in the design of the insert during the construction of a candidate virus-vector vaccine or control positive samples in diagnostic methods based on the indication of viral genome fragments

Clinical examination of the eyes functional status and assessment of equivalent dose to eye lens in medical staff performing endovascular interventions under X-ray guidance

Growing use of X-ray guided surgery interventions leads to increase in the risk of radiation side effects in medical staff participating in image-guided interventional procedures. In this connection to protect health and ensure professional longevity of the interventionists are important scientific and social problems. The purpose of the study presented in the article is to assess radiation dose to the lens of eyes, doses to whole body and hands of medical staff performing X-ray-guided endovascular proce-dures. Doses were measured with the use of thermoluminescent dosimeters. Due to clinical eye ex-amination for above staff to assess abilities to refract the light existence of involution changes, which are unusual for a specific age of an examined person, are found. The study proves that new annual equivalent dose limit for the lens of the eyes of 20 mSv recommended by the IAEA is justified

Social and pedagogical conditions of formation the students culture of communication by means of socio-cultural creativity

© 2017 Serials Publications.The article is devoted to the research of formation the student's culture of communication between different nationalities. The main directions of the organization of formation of culture of international dialogue related to the implementation of multicultural environment, ensuring the development of native culture, its history, traditions and moral values. Socio-cultural creativity as a means of formation of culture of international dialogue presented in this study is aimed at providing opportunities for young people to gain access to cultural values, to create favorable conditions for the creation, development and implementation of measures aimed at the organization and support of the national, national and international festivals, as well as support for the priority areas of innovation in the social and cultural sphere. The article presents the results of the research of formation the culture of international dialogue of students by means of social and cultural creativity. Materials of article can be recommended for the development the culture of communication in future work of teachers, organizers, managers

Isolation of Rabies Virus Glycoprotein Using Three-Phase Extraction and Characteristics of its Antigenic Properties

The aim of the work was to develop an approach to isolation of rabies virus glycoprotein applying threephase extraction and to characterize its antigenic properties.Materials and methods. Infectious activity of the rabies virus (production strain, “Ovine” GNKI) after long-term storage was restored on white BALB/c mice. The strain was used for cultivation on BHK-21 cells; the culture liquid was concentrated applying ultracentrifugation followed by separation by buoyant density in a sucrose gradient, selection of visually opalescent zones, phase concentration, chromatographic separation on an ENrich™ SEC650 column (Bio-Rad, USA) and selection of monomeric fractions with high serological activity according to the results of Western blotting.Results and discussion. We have demonstrated that preliminary mechanical destruction of brain suspension, extraction of the virus-containing material from the cell suspension through successive low-speed and high-speed centrifugation, separation of the sediment produced in sucrose gradient with further phase concentration and chromatographic separation of the precipitate allows to obtain monomeric antigenic preparations with high serological activity. This methodology has made it possible to obtain an antigen, which is rabies virus glycoprotein with a molecular weight of 67 kDa, and two of its isoforms, having molecular weights of 60 and 54 kDa. The described approach can be viewed as an option for isolation of the rabies virus specific antigen when improving laboratory diagnostics techniques. The resulting antigen is a monomeric discrete containing one fraction with a molecu lar weight of 67 kDa. The data obtained corroborate the high specificity of the antigen and its suitability for the design of enzyme immunoassay and immunochromatographic tests, production of specific immunoglobulins, the study of the antigen/antibody interaction, as well as for the assessment of the protective immunity intensity after vaccination

Piecewise Linear Models for the Quasiperiodic Transition to Chaos

We formulate and study analytically and computationally two families of piecewise linear degree one circle maps. These families offer the rare advantage of being non-trivial but essentially solvable models for the phenomenon of mode-locking and the quasi-periodic transition to chaos. For instance, for these families, we obtain complete solutions to several questions still largely unanswered for families of smooth circle maps. Our main results describe (1) the sets of maps in these families having some prescribed rotation interval; (2) the boundaries between zero and positive topological entropy and between zero length and non-zero length rotation interval; and (3) the structure and bifurcations of the attractors in one of these families. We discuss the interpretation of these maps as low-order spline approximations to the classic ``sine-circle'' map and examine more generally the implications of our results for the case of smooth circle maps. We also mention a possible connection to recent experiments on models of a driven Josephson junction.Comment: 75 pages, plain TeX, 47 figures (available on request

Viral Vector Vaccines Against ASF: Problems and Prospectives

African swine fever (ASF) is a highly contagious viral disease affecting pigs, with mortality rates a primary focus as they can reach up to 100%. The widespread and colossal economic losses from ASF have impacts on the development of animal husbandry practices in most countries within Africa, Asia, and Europe. Currently, a variety of approaches toward the development of vaccines against ASF are being employed. A promising new concept centered around more economical and time-consuming vaccine production is based on the use of viral vectors to deliver selected immunogens. This review discusses the results obtained from testing various viral vectors as carriers of targeted ASF virus genes. The safety and prospects of viral vectors, the possibilities around modulating cellular and humoral immune responses by choosing genes expressing immunodominant antigens, and the degree of protection in experimental animals from infection with a lethal dose of virulent ASF virus strains have been shown and discussed

Effective Light Converters Based on Mesogenic B-Diketonate Complexes of Europium

A Eu3+ mesogenic complex was obtained and demonstrated the possibility of its application as a efficient light converter. It was shown that it is possible to obtain photo- and thermally stable film light converters that effectively absorb in the visible region λ=395-405 nm.Работа выполнена при финансовой поддержке гранта РНФ 18-13-00112

Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis

The transcription factor Prox1 plays a crucial role in intermediate progenitor maintenance and hippocampal neuron differentiation during adult neurogenesis in the dentate gyrus region of the hippocampus

Анализ данных о методиках клинической оценки, указанных в клинических рекомендациях, размещенных на информационном ресурсе Минздрава России «Рубрикатор клинических рекомендаций»

One of the key elements of medical care is the assessment of the patient’s condition, which allows making a diagnosis and evaluating the patient’s health status, the severity of the disease  and the prognosis of its outcome. To date, medical professionals use various methods of assessing the patient’s condition; these methods are listed in “Clinical Recommendations”  posted in the information resource of the Ministry of Healthcare of Russia.Objective: to analyze and systemize the many methods of clinical evaluation, e. g. scores, indices, questionnaires and other approaches that appear in the clinical guidelines.Methods. We analyzed the clinical guidelines developed by professional non-profit medical  organizations and posted on the information resource of the Ministry of Healthcare of the Russian Federation under the “Clinical Recommendations” category. A list of clinical assessment methods  derived from these guidelines was composed and potential problems in their implementation by medical organizations were identified.Results. The unified list of clinical assessments presented in the guidelines includes 175 clinical  assessment methods. The most common methods of clinical evaluation were the VAS pain score  (in 23 clinical guidelines), the Glasgow coma scale (in 11 clinical guidelines), and the ECOG scale  (in 10 clinical guidelines).Conclusion. The methods of clinical evaluation, indicated in the Minzdrav information resource  are narrowly specialized; they are used and interpreted by a physician. Some important  information about these methods and their validation is missing, which necessitates further  efforts by the medical community to improve and update these methods.Одним из ключевых элементов оказания медицинской помощи является оценка состояния пациента, которая позволяет установить диагноз, оценить состояние здоровья пациента в  настоящий момент, степень тяжести заболевания (и его  осложнений) и прогноз его течения. На сегодняшний день  медицинскими специалистами разных направлений оказания  медицинской помощи применяется множество методик оценки  состояния пациента, которые они использовали в клинических  рекомендациях (КР) по диагностике и лечению заболеваний,  размещенных на информационном ресурсе Минздрава России «Рубрикатор клинических рекомендаций».Цель – систематизация данных о применяемых в отечественных клинических рекомендациях шкалах, индексах, опросниках и других методиках клинической оценки состояния пациента.Материалы и методы. Проведен анализ клинических рекомендаций, утвержденных профессиональными  некоммерческими медицинскими организациями и размещенных  на информационном ресурсе Министерства здравоохранения  Российской Федерации «Рубрикатор клинических рекомендаций», в части методик клинической оценки. Сформирован перечень методик клинической оценки, указанных в КР, выявлены возможные препятствия при внедрении медицинскими организациями методик клинической оценки.Результаты. Сформирован единый перечень методик клинической оценки, включающий в себя 175 методик,  представленных в КР. Наиболее распространенными в КР  методиками клинической оценки оказалась шкала боли VAS  (упоминается в 23 клинических рекомендациях), шкала комы по  Glasgow (упоминается в 11 клинических рекомендациях), шкала ECOG (упоминается в 10 КР).Заключение. Методики клинической оценки, указанные в КР, в основном являются узкоспециализированными, применяются и  оцениваются врачом. В связи с отсутствием во многих КР  необходимых сведений о методиках и данных об их валидации  необходимо продолжение работ профессионального медицинского сообщества по актуализации данных методик