The e-Business Readiness Composite Indicator for 2003. A Pilot Study

Abstract not availableJRC.G-Institute for the Protection and the Security of the Citizen (Ispra

Cerebral Oxygenation During the First Days of Life in Preterm and Term Neonates:Differences Between Different Brain Regions

Near-infrared spectroscopy is a noninvasive method for monitoring brain oxygenation. The aim of the study was to investigate differences between cerebral oxygenation in different brain regions in newborns. In a prospective study, we monitored simultaneously left and right frontoparietal and temporo-occipital regional cerebral oxygen saturation (rScO(2)) and cerebral fractional tissue extraction (cFTOE: (arterial oxygen saturation (SaO(2)) - rScO(2))/SaO(2)) using near-infrared spectroscopy. A 2-h measurement was performed on d 1, 3, and 7. We included 10 very preterm (GA = 37 wk) neonates. Limits of agreement for difference of the measurements between different places were determined using the Bland-Altman method. In all subgroups, the rScO(2) and cFTOE values at different regions were not different. Limits of agreement were between +/- 14 and +/- 18% for all subgroups. Left-to-right differences were small between different postnatal and GAs. A decrease and increase over time for rScO(2) and cFTOE values was detected for all four brain regions, most pronounced for infants with G

Effect of balloon atrial septostomy on cerebral oxygenation in neonates with transposition of the great arteries

<p>BACKGROUND: The aim of this study was to determine the effect of balloon atrial septostomy (BAS) on cerebral oxygenation in neonates with transposition of the great arteries (TGA).</p><p>METHODS: In term neonates with TGA, regional cerebral tissue oxygen saturation (r(c)SO(2)) was measured using, near-infrared spectroscopy (NIRS) for a period of 2 h, before BAS, after BAS, and 24 h after BAS. In neonates who did not require BAS on clinical,grounds, r(c)SO(2) was measured within 24h of admission and 24h later.</p><p>RESULTS: BAS was performed in 12 of 21 neonates. r(c)SO(2) increased from a median of 42% (before) to 48% at 2 h after BAS (P <0.05), as did transcutaneous arterial oxygen saturation (spO(2)) (from 72% to 85%, P <0.01). r(c)SO(2) increased further during the next 24 h (from 48% to 64%, P <0.05), whereas spO(2) remained stable. Although beginning from a lower baseline (42 vs. 51%, P <0.01), r(c)SO(2) Was higher in neonates treated with BAS, as compared with neonates not treated with BAS, 24h after the procedure (64 vs. 58%, P <0.05); spO(2) was, however, similar between the two groups.</p><p>CONCLUSION: BAS improves cerebral oxygen saturation in neonates with TGA. Complete recovery of cerebral oxygen saturation occurred only 24h after BAS.</p>