Link Prediction via Generalized Coupled Tensor Factorisation

This study deals with the missing link prediction problem: the problem of predicting the existence of missing connections between entities of interest. We address link prediction using coupled analysis of relational datasets represented as heterogeneous data, i.e., datasets in the form of matrices and higher-order tensors. We propose to use an approach based on probabilistic interpretation of tensor factorisation models, i.e., Generalised Coupled Tensor Factorisation, which can simultaneously fit a large class of tensor models to higher-order tensors/matrices with com- mon latent factors using different loss functions. Numerical experiments demonstrate that joint analysis of data from multiple sources via coupled factorisation improves the link prediction performance and the selection of right loss function and tensor model is crucial for accurately predicting missing links

Definitive hypofractionated radiotherapy for early glottic carcinoma: experience of 55Gy in 20 fractions

Introduction: A wide variety of fractionation schedules have been employed for the treatment of early glottic cancer. The aim is to report our 10-year experience of using hypofractionated radiotherapy with 55Gy in 20 fractions at 2.75Gy per fraction. Methods: Patients treated between 2004 and 2013 with definitive radiotherapy to a dose of 55Gy in 20 fractions over 4 weeks for T1/2 N0 squamous cell carcinoma of the glottis were retrospectively identified. Patients with prior therapeutic minor surgery (eg. laser stripping, cordotomy) were included. The probabilities of local control, ultimate local control (including salvage surgery), regional control, cause specific survival (CSS) and overall survival (OS) were calculated. Results: One hundred thirty-two patients were identified. Median age was 65 years (range 33–89). Median follow up was 72 months (range 7–124). 50 (38 %), 18 (14 %) and 64 (48 %) of patients had T1a, T1b and T2 disease respectively. Five year local control and ultimate local control rates were: overall - 85.6 % and 97.3 % respectively, T1a - 91.8 % and 100 %, T1b - 81.6 and 93.8 %, and T2 - 80.9 % and 95.8 %. Five year regional control, CSS and OS rates were 95.4 %, 95.7 % and 78.8 % respectively. There were no significant associations of covariates (e.g. T-stage, extent of laryngeal extension, histological grade) with local control on univariate analysis. Only increasing age and transglottic extension in T2 disease were significantly associated with overall survival (both p <0.01). Second primary cancers developed in 17 % of patients. 13 (9.8 %) of patients required enteral tube feeding support during radiotherapy; no patients required long term enteral nutrition. One patient required a tracheostomy due to a non-functioning larynx on long term follow up. Conclusions: Hypofractionated radiation therapy with a dose of 55Gy in 20 fractions for early stage glottic cancer provides high rates of local control with acceptable toxicity

VSC BASED D-STATCOM WITH SELECTIVE HARMONIC ELIMINATION

This paper describes the design, implementation and performance of a medium-size distribution type static synchronous compensator (D-STATCOM) with the simplest 2-level, 3-leg VSC topology. Reactive power control is achieved by phase-shift-angle control, and voltage source converter (VSC) harmonics arc eliminated by selective harmonic elimination method (SHEM) technique. VSC has been designed at the highest low-voltage level of 1 kV, and connected to medium-voltage (MV) bus through a low-pass input filter and AN connected MV/1 kV coupling transformer. At the medium-voltage side of D-STATCOM, line current harmonics are minimized to comply with IEEE Std. 519-1992 for the weakest supply conditions by applying 8-angle TLN2 elimination technique. This makes necessary switching the water-cooled high voltage (HV) IGBT modules at 850 Hz, thus eliminating 5(th), 7(th), 11(th), 13(th), 17(th), 19(th), 23(rd) and 25(th) voltage harmonics at the input of VSC. By carefully designing the laminated bus system, and selecting minimum stray inductance de link capacitors directly mountable on the laminated bus, stray inductance of commutation path is brought to a nearly absolute minimum of 60 nH, thus maximizing the utilization of wire bond, single-side cooled HV IGBTs, and eliminating the need to RCD clamping snubbers, The performance of SHEM together phase-shift-angle control has been tested in the field on a 0-1780 kVAr capacitive, 6.3 kV VSC based D-STATCOM (-750/+900 kVAr VSC) prototype. Field test results show that SHEM together with phase-shift-angle control leads to optimum switching frequency, and device utilization for HV IGBTs and high system performance at the expense of slower response as compared to other known control techniques

Unity power factor boost converter with phase shifted parallel IGBT operation for medium power applications

Phase-shifted parallel (PSP) operation of IGBTs is proposed for unity pf boost converters, to increase both the converter power rating and operating frequency. This technique allows unity pf operation of medium power AC and DC motor drives, and switch mode power supplies from a single-phase, unregulated AC supply, with minimum line current harmonic distortion. Since operating frequency is increased by integer multiples of IGBT switching frequency, the same core size for the boost inductor can be used to transfer larger amounts of power at the expense of additional power switching elements and a simple pulse separation circuit. Equal average current sharing is inherent in PSP operation strategy without any external circuits for equalisation. The design and implementation of a 28 kW, 40 kHz unity pf boost converter with two phase-shifted parallel IGBTs are presented. Advantages and disadvantages of PSP IGBT operation in increasing the power rating of boost converters are also given in comparison with other converter and power semiconductor parallel operation techniques

Biochemically Investigation of the Effects of Nettle Seed Herbal Mixture on Alcohol Damaged Liver

It was experimentally investigated in this research how protective Nettle Seed Herbal Mixture is against ethanol which causes oxidative stress in rats and causes toxic effects in the liver with chronic use. 20 4-month-old female Wistar male rats were used in the study. All rats in the study were fed with normal pellet Mouse food during the experiment. 10 week application was done by dividing the rats into four equal groups. Application method is orally drinking method. First group is the control group. The second group is the alcohol group. This group was given 30% ethanol in order to cause chronic alcoholisms. The third group was the alcohol+ Nettle Seed Herbal Mixture group and the rats in this group were given liquid, which was 30% ethanol,+ Nettle Seed Herbal Mixture extract. Fourth group was Nettle Seed Herbal Mixture extract group and the rats in this group were given liquid, which was Nettle Seed Herbal Mixture extract. At the end of ten weeks, within the first 24 hours, blood species were obtained from the animals under anesthesia using appropriate techniques. Serum ALT and AST values of the obtained blood samples were studied by enzymatic methods in "Roche Cobas 6000" device.. Biochemically ALT and AST enzyme values and statistical analysis with SPSS programe were done. No significant difference was found between these four groups at the end of the analysis because p value was bigger than 0,005.</p

Effects of Distributed Air-Gaps in the Iron-Core of Shunt Reactors on Inductance Components and Losses

In this paper, effects of dividing the air-gap in the iron-core of shunt reactors into several discrete gaps on inductance parameters of the equivalent circuit, core losses and gap losses are investigated. This is achieved by both analytical calculations and Finite Element Method based analyses. A new method called Moving Strip Method is also introduced to estimate the gap loss in the iron-core of shunt reactors having discretely distributed small air-gaps relative to those with large air-gaps. Theoretical results are verified by experiments carried out on an optimized shunt reactor. Results obtained in this work show that leakage inductance component in the equivalent circuit of the reactor can be brought to an absolute minimum and gap loss owing to fringing flux can be reduced significantly by distributing a large air-gap in the reactor core into several discretely distributed small air-gaps. These will simplify the design procedure of shunt reactors which will be used in utility grid applications. Copyright (c) 2012 Praise Worthy Prize S.r.l. - All rights reserved

Angiotensin-1 and vimentin expression and ultrastructural examination in severe preeclampsia complicated by HELLP syndrome changes in the structure of the umbilical cord

OBJECTIVE: The purpose of this study was to examine the histopathologic, ultrastructural and immunohistochemical changes in the umbilical cord in women diagnosed with HELLP syndrome. MATERIALS AND METHODS: Postpartum umbilical cords of 40 patients at the 35-38th week of pregnancy were included. 20 severe preeclamptic (HELLP) and 20 normal umbilical cords were used. After the follow-up of tissue parts of 10% formaldehyde solution for histopathology and immunohistochemistry, histopathological and angiopoietin-1 and vimentin antibodies were examined as immunohistochemical after routine paraffin follow-up. For electron microscope analysis, umbilical cord samples were taken into 2.5% glutaral aldehyde solution. RESULTS: In the statistical comparison, mean difference in increased diameter and additional anomaly on the ultrasound of preeclamptic patients was statistically different compared to control patients. In the HELLP group, hyperplasia and degenerative changes, pyknosis of the endothelial cell nuclei of the vessels and apoptotic changes in some regions were observed. Immunohistochemical analysis showed that endothelial cells, basal membrane and fibroblast cells in the HELLP group expressed high levels of vimentin. Angiotensin-1 expression was increased in amniotic epithelial cells, endothelial cells and some pericyte cells. CONCLUSIONS: As a result, it was observed that the signaling that started with trophoblastic invasion with the effect of hypoxia in severe preeclampsia and continued with dysfunction in endothelial cells was parallel to the increase in angiotensin and vimentin receptors. It is thought that the ultrastructural change in endothelial cells may cause disruption of the collagenized structure in Wharton gel, which supports this, and may cause adverse effects in fetal development and nutrition