Strategies for Colorectal Cancer Screening

The incidence of colorectal cancer (CRC) is increasing worldwide. CRC has high mortality when detected at advanced stages, yet it is also highly preventable. Given the difficulties in implementing major lifestyle changes or widespread primary prevention strategies to decrease CRC risk, screening is the most powerful public health tool to reduce mortality. Screening methods are effective but have limitations. Furthermore, many screen-eligible persons remain unscreened. We discuss established and emerging screening methods, and potential strategies to address current limitations in CRC screening. A quantum step in CRC prevention might come with the development of new screening strategies, but great gains can be made by deploying the available CRC screening modalities in ways that optimize outcomes while making judicious use of resources

On the topology and area of higher dimensional black holes

Over the past decade there has been an increasing interest in the study of black holes, and related objects, in higher (and lower) dimensions, motivated to a large extent by developments in string theory. The aim of the present paper is to obtain higher dimensional analogues of some well known results for black holes in 3+1 dimensions. More precisely, we obtain extensions to higher dimensions of Hawking's black hole topology theorem for asymptotically flat ($\Lambda=0$) black hole spacetimes, and Gibbons' and Woolgar's genus dependent, lower entropy bound for topological black holes in asymptotically locally anti-de Sitter ($\Lambda<0$) spacetimes. In higher dimensions the genus is replaced by the so-called $\sigma$-constant, or Yamabe invariant, which is a fundamental topological invariant of smooth compact manifolds.Comment: 15 pages, Latex2e; typos corrected, a convention clarified, resulting in the simplification of certain formulas, other improvement

Stability of Horava-Lifshitz Black Holes in the Context of AdS/CFT

The anti--de Sitter/conformal field theory (AdS/CFT) correspondence is a powerful tool that promises to provide new insights toward a full understanding of field theories under extreme conditions, including but not limited to quark-gluon plasma, Fermi liquid and superconductor. In many such applications, one typically models the field theory with asymptotically AdS black holes. These black holes are subjected to stringy effects that might render them unstable. Ho\v{r}ava-Lifshitz gravity, in which space and time undergo different transformations, has attracted attentions due to its power-counting renormalizability. In terms of AdS/CFT correspondence, Ho\v{r}ava-Lifshitz black holes might be useful to model holographic superconductors with Lifshitz scaling symmetry. It is thus interesting to study the stringy stability of Ho\v{r}ava-Lifshitz black holes in the context of AdS/CFT. We find that uncharged topological black holes in $\lambda=1$ Ho\v{r}ava-Lifshitz theory are nonperturbatively stable, unlike their counterparts in Einstein gravity, with the possible exceptions of negatively curved black holes with detailed balance parameter $\epsilon$ close to unity. Sufficiently charged flat black holes for $\epsilon$ close to unity, and sufficiently charged positively curved black holes with $\epsilon$ close to zero, are also unstable. The implication to the Ho\v{r}ava-Lifshitz holographic superconductor is discussed.Comment: 15 pages, 6 figures. Updated version accepted by Phys. Rev. D, with corrections to various misprints. References update

The Constraints in Spherically Symmetric General Relativity II --- Identifying the Configuration Space: A Moment of Time Symmetry

We continue our investigation of the configuration space of general relativity begun in I (gr-qc/9411009). Here we examine the Hamiltonian constraint when the spatial geometry is momentarily static (MS). We show that MS configurations satisfy both the positive quasi-local mass (QLM) theorem and its converse. We derive an analytical expression for the spatial metric in the neighborhood of a generic singularity. The corresponding curvature singularity shows up in the traceless component of the Ricci tensor. We show that if the energy density of matter is monotonically decreasing, the geometry cannot be singular. A supermetric on the configuration space which distinguishes between singular geometries and non-singular ones is constructed explicitly. Global necessary and sufficient criteria for the formation of trapped surfaces and singularities are framed in terms of inequalities which relate appropriate measures of the material energy content on a given support to a measure of its volume. The strength of these inequalities is gauged by exploiting the exactly solvable piece-wise constant density star as a template.Comment: 50 pages, Plain Tex, 1 figure available from the authors

Combined Global and Local Search for the Falsification of Hybrid Systems

In this paper we solve the problem of finding a trajectory that shows that a given hybrid dynamical system with deterministic evolution leaves a given set of states considered to be safe. The algorithm combines local with global search for achieving both efficiency and global convergence. In local search, it exploits derivatives for efficient computation. Unlike other methods for falsification of hybrid systems with deterministic evolution, we do not restrict our search to trajectories of a certain bounded length but search for error trajectories of arbitrary length

Blow-up solutions for linear perturbations of the Yamabe equation

For a smooth, compact Riemannian manifold (M,g) of dimension N \geg 3, we are interested in the critical equation $$\Delta_g u+(N-2/4(N-1) S_g+\epsilon h)u=u^{N+2/N-2} in M, u>0 in M,$$ where \Delta_g is the Laplace--Beltrami operator, S_g is the Scalar curvature of (M,g), $h\in C^{0,\alpha}(M)$, and $\epsilon$ is a small parameter

Gravitating Opposites Attract

Generalizing previous work by two of us, we prove the non-existence of certain stationary configurations in General Relativity having a spatial reflection symmetry across a non-compact surface disjoint from the matter region. Our results cover cases such that of two symmetrically arranged rotating bodies with anti-aligned spins in $n+1$ ($n \geq 3$) dimensions, or two symmetrically arranged static bodies with opposite charges in 3+1 dimensions. They also cover certain symmetric configurations in (3+1)-dimensional gravity coupled to a collection of scalars and abelian vector fields, such as arise in supergravity and Kaluza-Klein models. We also treat the bosonic sector of simple supergravity in 4+1 dimensions.Comment: 13 pages; slightly amended version, some references added, matches version to be published in Classical and Quantum Gravit

Torus-Fibered Calabi-Yau Threefolds with Non-Trivial Fundamental Group

We construct smooth Calabi-Yau threefolds Z, torus-fibered over a dP_9 base, with fundamental group Z_2 X Z_2. To do this, the structure of rational elliptic surfaces is studied and it is shown that a restricted subset of such surfaces admit at least a Z_2 X Z_2 group of automorphisms. One then constructs Calabi-Yau threefolds X as the fiber product of two such dP_9 surfaces, demonstrating that the involutions on the surfaces lift to a freely acting Z_2 X Z_2 group of automorphisms on X. The threefolds Z are then obtained as the quotient Z=X/(Z_2 X Z_2). These Calabi-Yau spaces Z admit stable, holomorphic SU(4) vector bundles which, in conjunction with Z_2 X Z_2 Wilson lines, lead to standard-like models of particle physics with naturally suppressed nucleon decay.Comment: 60 pages, 13 figures, Typos correcte

The Jang equation, apparent horizons, and the Penrose inequality

The Jang equation in the spherically symmetric case reduces to a first order equation. This permits an easy analysis of the role apparent horizons play in the (non)existence of solutions. We demonstrate that the proposed derivation of the Penrose inequality based on the Jang equation cannot work in the spherically symmetric case. Thus it is fruitless to apply this method, as it stands, to the general case. We show also that those analytic criteria for the formation of horizons that are based on the use of the Jang equation are of limited validity for the proof of the trapped surface conjecture.Comment: minor misprints correcte

Quasi-Asimptotically Flat Spacetimes and Their ADM Mass

We define spacetimes that are asymptotically flat, except for a deficit solid angle $\alpha$, and present a definition of their ``ADM'' mass, which is finite for this class of spacetimes, and, in particular, coincides with the value of the parameter $M$ of the global monopole spacetime studied by Vilenkin and Barriola . Moreover, we show that the definition is coordinate independent, and explain why it can, in some cases, be negative.Comment: Late