24 research outputs found
Digital Twin Application in Teaching Students Majoring in Metallurgical Engineering
The article addresses the crucial issues of training engineering personnel with the use of digital twins. In particular, application of digital twins is highly relevant when it comes to training of metallurgical engineering students. At present, teaching of students majoring in metallurgy involving the use of casting aluminum alloys physical models has a number of restrictions such as a high cost of expandable material, safety regulations, the need to provide special access. In this context, the purpose of this article is to identify the advantages and disadvantages of the digital twin of mo dern technology for casting aluminum alloys for application in the educational process. The digital twin created at the Siberian Federal University is a digital analogue of modern industrial complexes used at metallurgical enterprises. The methodological support and a script provided testing of the digital twin on the masterβs students studying in the educational program 22.04.02.07 βTheory and technology of foundry production of non-ferrous metals and alloysβ, direction of training 22.04.02 Metallurgy. The educational functionality of the model consists in passing the scenarios in the training and examination modes, which enables to test theoretical knowledge, gain skills and consolidate the skills of students. The training mode includes the necessary sequence of actions for passing one of the scenarios. The exam mode monitors userβs actions with saving his history, on the basis of which a report with the final grade is formed. It is planned that as a result of using the digital twin of the semicontinuous casting of aluminum alloys in the educational process, graduates will develop general professional, professional mandatory and professional competencies
Bioluminescent enzyme inhibition-based assay to predict the potential toxicity of carbon nanomaterials
ΠΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π Ρ Π΄Π΅ΡΠ΅ΠΉ Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΏΠΎΠ΄ΡΠ΅ΠΌΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ
Objective. Study of clinical and epidemiological characteristicsof hepatitis A in children.Materials and methods. The paper presents the epidemiologicalΒ situation of this issue in the Krasnoyarsk Territory,Β as well as the results of clinical observations of 104 childrenΒ with hepatitis A in age from 1 to 14 years.Results. It was found that at the present time is markedΒ deterioration of the epidemiological situation of hepatitisΒ A with involvement in the epidemiological process of youngΒ children. In this severe hepatitis A, often occurring with theΒ phenomena of cholestasis, significantly more frequent amongΒ children aged 7β14 years. Despite the apparent beneficialΒ for the infection at discharge on the part of school-age childrenΒ has been a recovery with residual effects that requireΒ continued monitoring and corrective therapy appointment.Π¦Π΅Π»Ρ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π (ΠΠ) Ρ Π΄Π΅ΡΠ΅ΠΉ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΈΡΡΠ°ΡΠΈΡ ΠΏΠΎ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ Π² ΠΡΠ°ΡΠ½ΠΎΡΡΡΠΊΠΎΠΌΒ ΠΊΡΠ°Π΅, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π·Π°Β 104 Π΄Π΅ΡΡΠΌΠΈ Ρ ΠΠ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 1 Π΄ΠΎ 14 Π»Π΅Ρ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡΒ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΡ
ΡΠ΄ΡΠ΅Π½ΠΈΠ΅ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ°ΡΠΈΠΈ ΠΏΠΎΒ ΠΠ Ρ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ΠΌ Π² ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠΎΡΠ΅ΡΡ Π΄Π΅ΡΠ΅ΠΉΒ ΡΠ°Π½Π½Π΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. ΠΡΠΈ ΡΡΠΎΠΌ ΡΡΠΆΠ΅Π»ΡΠ΅ ΡΠΎΡΠΌΡ ΠΠ, Π·Π°ΡΠ°ΡΡΡΡ ΠΏΡΠΎΡΠ΅ΠΊΠ°ΡΡΠΈΠ΅ Ρ ΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ Ρ
ΠΎΠ»Π΅ΡΡΠ°Π·Π°, Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ°ΡΠ΅ Π²ΡΡΡΠ΅ΡΠ°ΡΡΡΡ Ρ Π΄Π΅ΡΠ΅ΠΉ 7β14 Π»Π΅Ρ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π°Β ΠΊΠ°ΠΆΡΡΠ΅Π΅ΡΡ Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π΄Π°Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ,Β ΠΏΡΠΈ Π²ΡΠΏΠΈΡΠΊΠ΅ Ρ ΡΠ°ΡΡΠΈ Π΄Π΅ΡΠ΅ΠΉ ΡΠΊΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΈΠΌΠ΅Π»ΠΎΒ ΠΌΠ΅ΡΡΠΎ Π²ΡΠ·Π΄ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Ρ ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΠΌΠΈ ΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ, ΡΡΠΎΒ ΡΡΠ΅Π±ΠΎΠ²Π°Π»ΠΎ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½ΠΈΡ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΈ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΊΠΎΡΡΠΈΠ³ΠΈΡΡΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ
Research of rolling regimes and mechanical properties of cold-rolled, annealed and welded semi-finished products from experimental alloys of Al-Mg system, economically alloyed by scandium
Π’Π΅ΠΊΡΡ ΡΡΠ°ΡΡΠΈ Π½Π΅ ΠΏΡΠ±Π»ΠΈΠΊΡΠ΅ΡΡΡ Π² ΠΎΡΠΊΡΡΡΠΎΠΌ Π΄ΠΎΡΡΡΠΏΠ΅ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΏΠΎΠ»ΠΈΡΠΈΠΊΠΎΠΉ ΠΆΡΡΠ½Π°Π»Π°.Our paper shows the research results of thermodeformation machining of flat ingots made of experimental aluminium alloys, containing magnesium, scandium, rare-earth and transition metals. Relevance of the work aimed at creating the new Al-Mg system alloys, alloyed by scandium, and technologies for obtaining deformed semi-finished products from them using metal forming operations are shown. Regimes of hot and cold sheet rolling for obtaining strips with thickness 1-3 mm from these alloys were calculated and experimentally tested. Experimental research included the following steps: preparation of flat slabs with dimensions 28-150-300 mm for rolling; hot rolling at the temperature of 450 Β°C with total draw ratio about 6; cold rolling with total draw ratio about 5; annealing of cold-deformed semi-finished products at the temperature of 350 Β°C within 3 hours; argon-arc welding of the obtained strips along and across the direction of deformation; intergranular corrosion test; evaluation of mechanical properties of the samples. As a result, the nature and degree of corrosion destruction were studied and mechanical properties of deformed, annealed and welded semi-finished products from experimental alloys were determined. It is established that they have a high level of strength and plastic properties of the metal along, across and at an angle 45o relative to the direction of rolling. So tensile strength reaches the value 500-520 MPa for deformed samples, yield strength of metal 435-470 MPa, relative elongation 4.8-6.7%, and for annealed samples the values of the relative elongation increase and can reach 14.0-14.5% at the sufficiently high yield strength 357-369 MPa. Tests for intergranular corrosion of samples after welding showed high corrosion resistance of welded joints. The strength of the welded seam is 0.75-0.85 of the strength of the base metal. The results of research can be recommended for the development of technology for the manufacture of parts from flat products, including welded joints
Thermoinactivation of Coupled Enzyme System of Luminous Bacteria NADH:FMN-Oxidoreductase-Luciferase in Gelatin
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΆΠ΅Π»Π°ΡΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΈ Π³Π΅Π»Ρ Π½Π° Π±ΠΈΠΎΠ»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΡ Π±ΠΈΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ
ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ²Π΅ΡΡΡΠΈΡ
ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ NADH:FMN-ΠΎΠΊΡΠΈΠ΄ΠΎΡΠ΅Π΄ΡΠΊΡΠ°Π·Π°-Π»ΡΡΠΈΡΠ΅ΡΠ°Π·Π°, ΠΈΠ·ΡΡΠ΅Π½Ρ
ΡΠ΅ΡΠΌΠΎΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΠΈ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½Π°Ρ ΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π±ΠΈΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² ΠΆΠ΅Π»Π°ΡΠΈΠ½ΠΎΠ²ΠΎΠΌ
ΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΠΈ. ΠΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π±ΠΈΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠ° Π΅Ρ ΡΠ΅ΡΠΌΠΎΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π²
ΠΆΠ΅Π»Π°ΡΠΈΠ½Π΅ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ, Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΉ Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³Π΅Π»Ρ, ΠΈ Π² ΠΆΠ΅Π»Π°ΡΠΈΠ½Π΅
Π²ΡΡΠΎΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ, ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΠΉ ΠΊ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π³Π΅Π»Ρ, ΡΠ°Π·Π»ΠΈΡΠ°ΡΡΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ
ΡΠ΅ΡΠΌΠΎΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π±ΠΈΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈΠΌΠ΅Π΅Ρ Π½Π΅Π»ΠΈΠ½Π΅ΠΉΠ½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΈ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ
ΠΏΠΎ Π΄ΠΈΡΡΠΎΡΠΈΠ°ΡΠΈΠ²Π½ΠΎΠΌΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ. ΠΠ΅Π»Π΅Π²Π°Ρ ΠΌΠ°ΡΡΠΈΡΠ° ΠΆΠ΅Π»Π°ΡΠΈΠ½Π° ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΡΠ΅ΡΠΌΠ΅Π½ΡΡ
ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·ΠΈΡΡΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅. ΠΠΎΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ² Π² Π²ΡΠ·ΠΊΡΡ ΡΡΠ΅Π΄Ρ, ΡΠΎΠ·Π΄Π°Π½Π½ΡΡ Π³Π΅Π»Π΅Π²ΡΠΌ
ΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΆΠ΅Π»Π°ΡΠΈΠ½Π°, Π½Π΅ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΡΠΊΠΎΡΠΎΡΡΡ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ.Influence of gelatin solution and gel on bioluminescence of coupled enzymatic system of luminous
bacteria NADH:FMN-oxidoreductase-luciferase was analyzed, thermostability and thermoinactivation
of coupled enzyme system in gelatinous environment were studied. Activity of coupled enzyme system
and kinetics of its thermoinactivation in gelatin with low concentration, that is insufficient for gel
formation, and in gelatin with high concentration, that is sufficient for gel formation, was different. It
was determined that thermoinactivation of coupled enzyme system has nonlinear nature and occurs
with dissociative mechanism. It was showed that gel matrix of gelatin stabilizes enzymes. There was no
effect of viscous environment originating by gelatin surroundings on the rate of enzymatic reactions
Thermoinactivation of Coupled Enzyme System of Luminous Bacteria NADH:FMN-Oxidoreductase-Luciferase in Gelatin
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΆΠ΅Π»Π°ΡΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΈ Π³Π΅Π»Ρ Π½Π° Π±ΠΈΠΎΠ»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΡ Π±ΠΈΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ
ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ²Π΅ΡΡΡΠΈΡ
ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ NADH:FMN-ΠΎΠΊΡΠΈΠ΄ΠΎΡΠ΅Π΄ΡΠΊΡΠ°Π·Π°-Π»ΡΡΠΈΡΠ΅ΡΠ°Π·Π°, ΠΈΠ·ΡΡΠ΅Π½Ρ
ΡΠ΅ΡΠΌΠΎΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΠΈ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½Π°Ρ ΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π±ΠΈΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² ΠΆΠ΅Π»Π°ΡΠΈΠ½ΠΎΠ²ΠΎΠΌ
ΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΠΈ. ΠΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π±ΠΈΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠ° Π΅Ρ ΡΠ΅ΡΠΌΠΎΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π²
ΠΆΠ΅Π»Π°ΡΠΈΠ½Π΅ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ, Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΉ Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³Π΅Π»Ρ, ΠΈ Π² ΠΆΠ΅Π»Π°ΡΠΈΠ½Π΅
Π²ΡΡΠΎΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ, ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΠΉ ΠΊ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π³Π΅Π»Ρ, ΡΠ°Π·Π»ΠΈΡΠ°ΡΡΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ
ΡΠ΅ΡΠΌΠΎΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π±ΠΈΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈΠΌΠ΅Π΅Ρ Π½Π΅Π»ΠΈΠ½Π΅ΠΉΠ½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΈ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ
ΠΏΠΎ Π΄ΠΈΡΡΠΎΡΠΈΠ°ΡΠΈΠ²Π½ΠΎΠΌΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ. ΠΠ΅Π»Π΅Π²Π°Ρ ΠΌΠ°ΡΡΠΈΡΠ° ΠΆΠ΅Π»Π°ΡΠΈΠ½Π° ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΡΠ΅ΡΠΌΠ΅Π½ΡΡ
ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·ΠΈΡΡΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅. ΠΠΎΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ² Π² Π²ΡΠ·ΠΊΡΡ ΡΡΠ΅Π΄Ρ, ΡΠΎΠ·Π΄Π°Π½Π½ΡΡ Π³Π΅Π»Π΅Π²ΡΠΌ
ΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΆΠ΅Π»Π°ΡΠΈΠ½Π°, Π½Π΅ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΡΠΊΠΎΡΠΎΡΡΡ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ.Influence of gelatin solution and gel on bioluminescence of coupled enzymatic system of luminous
bacteria NADH:FMN-oxidoreductase-luciferase was analyzed, thermostability and thermoinactivation
of coupled enzyme system in gelatinous environment were studied. Activity of coupled enzyme system
and kinetics of its thermoinactivation in gelatin with low concentration, that is insufficient for gel
formation, and in gelatin with high concentration, that is sufficient for gel formation, was different. It
was determined that thermoinactivation of coupled enzyme system has nonlinear nature and occurs
with dissociative mechanism. It was showed that gel matrix of gelatin stabilizes enzymes. There was no
effect of viscous environment originating by gelatin surroundings on the rate of enzymatic reactions
Clinical and epidemiological characteristics of hepatitis A in children during rise of morbidity
Objective. Study of clinical and epidemiological characteristicsof hepatitis A in children.Materials and methods. The paper presents the epidemiologicalΒ situation of this issue in the Krasnoyarsk Territory,Β as well as the results of clinical observations of 104 childrenΒ with hepatitis A in age from 1 to 14 years.Results. It was found that at the present time is markedΒ deterioration of the epidemiological situation of hepatitisΒ A with involvement in the epidemiological process of youngΒ children. In this severe hepatitis A, often occurring with theΒ phenomena of cholestasis, significantly more frequent amongΒ children aged 7β14 years. Despite the apparent beneficialΒ for the infection at discharge on the part of school-age childrenΒ has been a recovery with residual effects that requireΒ continued monitoring and corrective therapy appointment